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Aliases for TPTE2 Gene

Aliases for TPTE2 Gene

  • Transmembrane Phosphoinositide 3-Phosphatase And Tensin Homolog 2 2 3 5
  • TPTE And PTEN Homologous Inositol Lipid Phosphatase 3 4
  • Lipid Phosphatase TPIP 3 4
  • TPIP 3 4
  • Transmembrane Phosphoinositide 3-Phosphatase And Tensin 2-Like Protein 3
  • Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase TPTE2 3
  • PTEN-Like Inositol Lipid Phosphatase 3
  • TPIP Lipid Phosphatase 3
  • EC 4

External Ids for TPTE2 Gene

Previous GeneCards Identifiers for TPTE2 Gene

  • GC13M017796
  • GC13M018895
  • GC13M019997
  • GC13M000801

Summaries for TPTE2 Gene

Entrez Gene Summary for TPTE2 Gene

  • TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]

GeneCards Summary for TPTE2 Gene

TPTE2 (Transmembrane Phosphoinositide 3-Phosphatase And Tensin Homolog 2) is a Protein Coding gene. Among its related pathways are PI Metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include ion channel activity and protein tyrosine phosphatase activity. An important paralog of this gene is TPTE.

Additional gene information for TPTE2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPTE2 Gene

Genomics for TPTE2 Gene

GeneHancer (GH) Regulatory Elements for TPTE2 Gene

Promoters and enhancers for TPTE2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I019561 Enhancer 0.4 Ensembl 550.8 0.0 -27 0.4 NR2C1 ZBTB33 ESRRAP1 TPTE2 CASC4P1 GC13M019563 MRPS31P2
GH13I019860 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 5 -301.5 -301495 4.9 HDGF PKNOX1 ARID4B NEUROD1 SIN3A ZNF2 YY1 SLC30A9 POLR2B ZNF143 ZMYM5 ENSG00000275964 ZMYM2 MPHOSPH8 PSPC1-AS2 ESRRAP1 RNU2-7P TPTE2 CRYL1 ENSG00000223576
GH13I020231 Promoter/Enhancer 1 EPDnew Ensembl 9.9 -670.6 -670577 1.9 CTCF SUZ12 POLR2A ZNF529 MAX MYC EZH2 GJB6 EEF1AKMT1 SLC35E1P1 TPTE2 MPHOSPH8 ENSG00000279065
GH13I019438 Enhancer 0.5 Ensembl 6.7 +122.6 122573 0.4 CTCF ZNF654 ZNF444 FOXA1 ZBTB17 TPTE2 CYCSP32 SLC25A15P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPTE2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPTE2 gene promoter:

Genomic Locations for TPTE2 Gene

Genomic Locations for TPTE2 Gene
138,698 bases
Minus strand

Genomic View for TPTE2 Gene

Genes around TPTE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPTE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPTE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPTE2 Gene

Proteins for TPTE2 Gene

  • Protein details for TPTE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2
    Protein Accession:
    Secondary Accessions:
    • A1A4X0
    • A1A4X1
    • A8MX64
    • B1AQ16
    • B4DWZ2
    • Q5VUH2
    • Q8WWL4
    • Q8WWL5

    Protein attributes for TPTE2 Gene

    522 amino acids
    Molecular mass:
    61112 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPTE2 Gene

neXtProt entry for TPTE2 Gene

Post-translational modifications for TPTE2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TPTE2 Gene

Domains & Families for TPTE2 Gene

Gene Families for TPTE2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TPTE2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TPTE2: view

No data available for UniProtKB/Swiss-Prot for TPTE2 Gene

Function for TPTE2 Gene

Molecular function for TPTE2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.

Enzyme Numbers (IUBMB) for TPTE2 Gene

Gene Ontology (GO) - Molecular Function for TPTE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity TAS --
genes like me logo Genes that share ontologies with TPTE2: view
genes like me logo Genes that share phenotypes with TPTE2: view

Animal Model Products

miRNA for TPTE2 Gene

miRTarBase miRNAs that target TPTE2

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPTE2 Gene

Localization for TPTE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPTE2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.
Isoform 4: Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPTE2 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TPTE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TPTE2: view

Pathways & Interactions for TPTE2 Gene

genes like me logo Genes that share pathways with TPTE2: view

Pathways by source for TPTE2 Gene

Interacting Proteins for TPTE2 Gene

Gene Ontology (GO) - Biological Process for TPTE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with TPTE2: view

No data available for SIGNOR curated interactions for TPTE2 Gene

Drugs & Compounds for TPTE2 Gene

(2) Drugs for TPTE2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(380) Additional Compounds for TPTE2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
genes like me logo Genes that share compounds with TPTE2: view

Transcripts for TPTE2 Gene

Unigene Clusters for TPTE2 Gene

Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPTE2 Gene

No ASD Table

Relevant External Links for TPTE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPTE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPTE2 Gene

mRNA differential expression in normal tissues according to GTEx for TPTE2 Gene

This gene is overexpressed in Testis (x24.0).

NURSA nuclear receptor signaling pathways regulating expression of TPTE2 Gene:


SOURCE GeneReport for Unigene cluster for TPTE2 Gene:


mRNA Expression by UniProt/SwissProt for TPTE2 Gene:

Tissue specificity: Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.
genes like me logo Genes that share expression patterns with TPTE2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPTE2 Gene

Orthologs for TPTE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPTE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPTE2 33 34
  • 99.17 (n)
(Canis familiaris)
Mammalia LOC606856 33
  • 79.36 (n)
-- 34
  • 48 (a)
(Bos Taurus)
Mammalia LOC516736 33
  • 76.29 (n)
-- 34
  • 65 (a)
(Mus musculus)
Mammalia Tpte 33 16 34
  • 75.33 (n)
(Rattus norvegicus)
Mammalia Tpte2 33
  • 73.97 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 43 (a)
(Gallus gallus)
Aves TPTE2 33
  • 64.37 (n)
-- 34
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
-- 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpte2 33
  • 62.51 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10039 33
(Danio rerio)
Actinopterygii tpte 33 34
  • 60.29 (n)
(Caenorhabditis elegans)
Secernentea dnj-25 34
  • 7 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PTEN1 33
  • 55.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for TPTE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPTE2 Gene

Gene Tree for TPTE2 (if available)
Gene Tree for TPTE2 (if available)

Paralogs for TPTE2 Gene

Paralogs for TPTE2 Gene

(6) SIMAP similar genes for TPTE2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TPTE2: view

Variants for TPTE2 Gene

Sequence variations from dbSNP and Humsavar for TPTE2 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000008667 -- 19,468,361(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000017231 -- 19,558,265(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000081267 -- 19,424,464(-) T/A intron_variant
rs1000115151 -- 19,538,013(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TPTE2 Gene

Variant ID Type Subtype PubMed ID
nsv1042541 CNV gain 25217958
esv3631389 CNV loss 21293372
esv3631388 CNV gain 21293372
esv3631387 CNV gain 21293372
esv3631384 CNV gain 21293372
esv3582126 CNV gain 25503493
esv2761244 CNV gain 21179565
esv2760291 CNV loss 21179565
esv2747051 CNV deletion 23290073
esv2677314 CNV deletion 23128226
esv26631 CNV loss 19812545
dgv334e199 CNV deletion 23128226
nsv977199 CNV duplication 23825009
nsv977198 CNV duplication 23825009
nsv950 CNV insertion 18451855
nsv561207 CNV gain 21841781
nsv561206 CNV loss 21841781
nsv561205 CNV loss 21841781
nsv523915 CNV loss 19592680
nsv523881 CNV gain 19592680
nsv523550 CNV gain 19592680
nsv516945 CNV gain+loss 19592680
nsv471122 CNV loss 18288195
nsv469567 CNV loss 16826518
nsv469566 CNV loss 16826518
nsv428286 CNV loss 18775914
nsv1151909 OTHER inversion 26484159
nsv1148310 CNV deletion 26484159
nsv1140246 OTHER inversion 24896259
nsv1115628 CNV deletion 24896259
nsv1078303 OTHER inversion 25765185
nsv1054226 CNV gain 25217958
nsv1051666 CNV gain 25217958
nsv1048889 CNV loss 25217958
nsv1047555 CNV loss 25217958
nsv1046064 CNV gain 25217958

Variation tolerance for TPTE2 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPTE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPTE2 Gene

Disorders for TPTE2 Gene

Additional Disease Information for TPTE2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TPTE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPTE2 Gene

Publications for TPTE2 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 2 3 4 58
  2. The TPTE gene family: cellular expression, subcellular localization and alternative splicing. (PMID: 14659893) Tapparel C … Antonarakis SE (Gene 2003) 3 4 22 58
  3. TPIP: a novel phosphoinositide 3-phosphatase. (PMID: 11716755) Walker SM … Leslie NR (The Biochemical journal 2001) 2 3 4 58
  4. A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells. (PMID: 22164291) Mishra RR … Rath PC (PloS one 2011) 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for TPTE2 Gene

Sources for TPTE2 Gene

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