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Aliases for TPT1 Gene

Aliases for TPT1 Gene

  • Tumor Protein, Translationally-Controlled 1 2 3 5
  • Histamine-Releasing Factor 3 4
  • Fortilin 3 4
  • TCTP 3 4
  • P23 3 4
  • HRF 3 4
  • Translationally-Controlled Tumor Protein 3
  • P02 3

External Ids for TPT1 Gene

Previous GeneCards Identifiers for TPT1 Gene

  • GC13M043911
  • GC13M039897
  • GC13M044847
  • GC13M043709
  • GC13M044810
  • GC13M044673
  • GC13M044815
  • GC13M044818
  • GC13M044821
  • GC13M044824
  • GC13M044827
  • GC13M044830
  • GC13M045912
  • GC13M045914
  • GC13M026712
  • GC13M045917
  • GC13M045921
  • GC13M045924
  • GC13M045937
  • GC13M045943
  • GC13M045955
  • GC13M045973

Summaries for TPT1 Gene

Entrez Gene Summary for TPT1 Gene

  • This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

GeneCards Summary for TPT1 Gene

TPT1 (Tumor Protein, Translationally-Controlled 1) is a Protein Coding gene. Diseases associated with TPT1 include Urticaria and Allergic Hypersensitivity Disease. Among its related pathways are DNA Damage and PLK1 signaling events. Gene Ontology (GO) annotations related to this gene include transcription factor binding.

UniProtKB/Swiss-Prot for TPT1 Gene

  • Involved in calcium binding and microtubule stabilization.

Gene Wiki entry for TPT1 Gene

Additional gene information for TPT1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPT1 Gene

Genomics for TPT1 Gene

GeneHancer (GH) Regulatory Elements for TPT1 Gene

Promoters and enhancers for TPT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I045338 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.6 600 4.6 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 TPT1-AS1 ENSG00000273149 GC13M045342 GC13M045343 TPT1 SLC25A30 SLC25A30-AS1
GH13I045370 Enhancer 0.9 Ensembl ENCODE 12.5 -29.9 -29870 0.9 CTCF RB1 BACH1 SIN3A ZNF2 RAD21 ZNF316 POLR2A ZNF143 PRDM10 TPT1 TPT1-AS1 SLC25A30 GC13P045378 GC13P045379 GC13P045380 PIR60049 ENSG00000228886
GH13I045372 Enhancer 0.8 ENCODE 12.5 -31.7 -31725 1.6 INSM2 FEZF1 ZNF2 ZSCAN5C ZNF391 ZNF202 ZNF280D ZNF362 OVOL3 TSHZ1 TPT1-AS1 SLC25A30 COG3 TPT1 SLC25A30-AS1 GC13P045378 GC13P045379 GC13P045380 PIR60049 ENSG00000228886
GH13I044902 Enhancer 1 Ensembl ENCODE dbSUPER 7.9 +436.4 436379 5.6 RFX1 BMI1 RAD21 NR2F2 FOXA1 JUND GATA3 POLR2A FOSL2 FOS TPT1 TPT1-AS1 RN7SL49P LOC105370187 TRE-TTC2-1
GH13I045204 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.1 +134.1 134081 5.4 ZSCAN4 BATF IRF4 ZSCAN5C SCRT2 ATF7 ETV6 FOS IKZF2 RUNX3 GTF2F2 KCTD4 TPT1 COG3 RNU6-69P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPT1 gene promoter:

Genomic Locations for TPT1 Gene

Genomic Locations for TPT1 Gene
chr13:45,333,471-45,341,370
(GRCh38/hg38)
Size:
7,900 bases
Orientation:
Minus strand
chr13:45,911,008-45,915,505
(GRCh37/hg19)

Genomic View for TPT1 Gene

Genes around TPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPT1 Gene

Proteins for TPT1 Gene

  • Protein details for TPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13693-TCTP_HUMAN
    Recommended name:
    Translationally-controlled tumor protein
    Protein Accession:
    P13693
    Secondary Accessions:
    • B2R7E5
    • Q6YLS2
    • Q7Z4J4
    • Q8TBK7
    • Q96EE2
    • Q9UC70

    Protein attributes for TPT1 Gene

    Size:
    172 amino acids
    Molecular mass:
    19595 Da
    Quaternary structure:
    • Interacts with STEAP3.

    Three dimensional structures from OCA and Proteopedia for TPT1 Gene

    Alternative splice isoforms for TPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPT1 Gene

Post-translational modifications for TPT1 Gene

  • Ubiquitination at posLast=102102 and isoforms=2164
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TPT1 Gene

Domains & Families for TPT1 Gene

Gene Families for TPT1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TPT1 Gene

Graphical View of Domain Structure for InterPro Entry

P13693

UniProtKB/Swiss-Prot:

TCTP_HUMAN :
  • Belongs to the TCTP family.
Family:
  • Belongs to the TCTP family.
genes like me logo Genes that share domains with TPT1: view

Function for TPT1 Gene

Molecular function for TPT1 Gene

GENATLAS Biochemistry:
tumor protein,translationally controlled 1
UniProtKB/Swiss-Prot Function:
Involved in calcium binding and microtubule stabilization.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection.

Phenotypes From GWAS Catalog for TPT1 Gene

Gene Ontology (GO) - Molecular Function for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005509 calcium ion binding IDA 15162379
GO:0005515 protein binding IPI 16730713
GO:0008017 microtubule binding IBA --
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with TPT1: view
genes like me logo Genes that share phenotypes with TPT1: view

Animal Models for TPT1 Gene

MGI Knock Outs for TPT1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TPT1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TPT1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPT1 Gene

Localization for TPT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPT1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endosome 5
plasma membrane 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA,IEA 15319436
GO:0005634 nucleus IDA 11598139
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm TAS 16130169
GO:0005771 multivesicular body IDA 15319436
genes like me logo Genes that share ontologies with TPT1: view

Pathways & Interactions for TPT1 Gene

genes like me logo Genes that share pathways with TPT1: view

Pathways by source for TPT1 Gene

1 BioSystems pathway for TPT1 Gene
4 Cell Signaling Technology pathways for TPT1 Gene

SIGNOR curated interactions for TPT1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IC 15958728
GO:0006874 cellular calcium ion homeostasis IC 15958728
GO:0009615 response to virus IEP 16548883
GO:0019827 stem cell population maintenance IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with TPT1: view

Drugs & Compounds for TPT1 Gene

(10) Drugs for TPT1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Calcium Citrate Approved Pharma Target, ligand 0
Calcium Phosphate Approved Pharma Target, ligand 0

(5) Additional Compounds for TPT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TPT1: view

Transcripts for TPT1 Gene

Unigene Clusters for TPT1 Gene

Tumor protein, translationally-controlled 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TPT1

Alternative Splicing Database (ASD) splice patterns (SP) for TPT1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:
SP7: -
SP8: - - - -
SP9: - -

Relevant External Links for TPT1 Gene

GeneLoc Exon Structure for
TPT1
ECgene alternative splicing isoforms for
TPT1

Expression for TPT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPT1 Gene

mRNA differential expression in normal tissues according to GTEx for TPT1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.1).

Protein differential expression in normal tissues from HIPED for TPT1 Gene

This gene is overexpressed in Oral epithelium (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPT1 Gene



Protein tissue co-expression partners for TPT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPT1 Gene:

TPT1

SOURCE GeneReport for Unigene cluster for TPT1 Gene:

Hs.374596

mRNA Expression by UniProt/SwissProt for TPT1 Gene:

P13693-TCTP_HUMAN
Tissue specificity: Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.

Evidence on tissue expression from TISSUES for TPT1 Gene

  • Liver(5)
  • Lung(5)
  • Pancreas(5)
  • Nervous system(5)
  • Blood(4.9)
  • Intestine(4.9)
  • Muscle(4.9)
  • Skin(4.9)
  • Eye(4.8)
  • Stomach(4.8)
  • Kidney(4.7)
  • Heart(4.6)
  • Bone(4.2)
  • Spleen(3.9)
  • Lymph node(3.1)
  • Adrenal gland(3)
  • Bone marrow(3)
  • Gall bladder(3)
  • Thyroid gland(3)
genes like me logo Genes that share expression patterns with TPT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPT1 Gene

Orthologs for TPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPT1 33 34
  • 99.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TPT1 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
OneToMany
TPT1 33 34 34
  • 96.51 (n)
dog
(Canis familiaris)
Mammalia TPT1 33 34
  • 95.74 (n)
rat
(Rattus norvegicus)
Mammalia Tpt1 33
  • 90.7 (n)
mouse
(Mus musculus)
Mammalia Tpt1 33 16 34
  • 90.31 (n)
oppossum
(Monodelphis domestica)
Mammalia TPT1 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPT1 33 34
  • 84.88 (n)
lizard
(Anolis carolinensis)
Reptilia TPT1 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tpt1 33
  • 70.54 (n)
Str.17076 33
African clawed frog
(Xenopus laevis)
Amphibia tpt1-prov 33
zebrafish
(Danio rerio)
Actinopterygii tpt1 33 34
  • 68.23 (n)
tctp 33
fruit fly
(Drosophila melanogaster)
Insecta Tctp 33 34
  • 57.68 (n)
CG4800 35
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta TCTP_ANOGA 33
  • 56.69 (n)
worm
(Caenorhabditis elegans)
Secernentea tct-1 33 34
  • 51.28 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA19 33 34 36
  • 56.29 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12716g 33
  • 55.49 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR075C 33
  • 53.49 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons TCTP 33
  • 51.61 (n)
rice
(Oryza sativa)
Liliopsida Os11g0660500 33
  • 51.81 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1F12.02c 33
  • 55.69 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06464 33
  • 54.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5297 34
  • 39 (a)
OneToOne
Species where no ortholog for TPT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPT1 Gene

ENSEMBL:
Gene Tree for TPT1 (if available)
TreeFam:
Gene Tree for TPT1 (if available)

Paralogs for TPT1 Gene

No data available for Paralogs for TPT1 Gene

Variants for TPT1 Gene

Sequence variations from dbSNP and Humsavar for TPT1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000473099 -- 45,335,426(-) G/A 3_prime_UTR_variant
rs1000835272 -- 45,340,908(-) C/T intron_variant
rs1000947155 -- 45,334,441(-) A/G 3_prime_UTR_variant
rs1001064935 -- 45,336,306(-) T/G 3_prime_UTR_variant
rs1001130814 -- 45,341,378(-) A/C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TPT1 Gene

Variant ID Type Subtype PubMed ID
nsv1046200 CNV gain 25217958
nsv477869 CNV novel sequence insertion 20440878
nsv510579 CNV deletion 20534489
nsv951078 CNV duplication 24416366
nsv977234 CNV duplication 23825009
nsv983582 CNV duplication 23825009

Variation tolerance for TPT1 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPT1 Gene

Disorders for TPT1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for TPT1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
urticaria
allergic hypersensitivity disease
  • allergic disease
asthma
  • asthma, susceptibility to
paraneoplastic cerebellar degeneration
mycetoma
  • madura foot
- elite association - COSMIC cancer census association via MalaCards
Search TPT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TPT1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TPT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPT1 Gene

Publications for TPT1 Gene

  1. The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells. (PMID: 15958728) Arcuri F … Cintorino M (Biology of reproduction 2005) 3 4 22 58
  2. Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity. (PMID: 15162379) Arcuri F … del Vecchio MT (The Prostate 2004) 3 4 22 58
  3. Plk phosphorylation regulates the microtubule-stabilizing protein TCTP. (PMID: 12167714) Yarm FR (Molecular and cellular biology 2002) 3 4 22 58
  4. Chromosomal localization of tumor protein, translationally-controlled 1 (TPT1) encoding the human histamine releasing factor (HRF) to 13q12-->q14. (PMID: 10343127) MacDonald SM … Jabs EW (Cytogenetics and cell genetics 1999) 2 3 22 58
  5. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. (PMID: 9059837) Sanchez JC … Hochstrasser D (Electrophoresis 1997) 3 4 22 58

Products for TPT1 Gene

  • Addgene plasmids for TPT1

Sources for TPT1 Gene

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