This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell di... See more...

Aliases for TPT1 Gene

Aliases for TPT1 Gene

  • Tumor Protein, Translationally-Controlled 1 2 3 5
  • Fortilin 2 3 4
  • TCTP 2 3 4
  • Translationally-Controlled Tumor Protein 3 4
  • Histamine-Releasing Factor 3 4
  • HRF 3 4
  • P23 3 4
  • TPT1 5
  • P02 3

External Ids for TPT1 Gene

Previous GeneCards Identifiers for TPT1 Gene

  • GC13M043911
  • GC13M039897
  • GC13M044847
  • GC13M043709
  • GC13M044810
  • GC13M044673
  • GC13M044815
  • GC13M044818
  • GC13M044821
  • GC13M044824
  • GC13M044827
  • GC13M044830
  • GC13M045912
  • GC13M045914
  • GC13M026712
  • GC13M045917
  • GC13M045921
  • GC13M045924
  • GC13M045937
  • GC13M045943
  • GC13M045955
  • GC13M045973

Summaries for TPT1 Gene

Entrez Gene Summary for TPT1 Gene

  • This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

CIViC Summary for TPT1 Gene

GeneCards Summary for TPT1 Gene

TPT1 (Tumor Protein, Translationally-Controlled 1) is a Protein Coding gene. Diseases associated with TPT1 include Urticaria and Drug Allergy. Among its related pathways are Ca, cAMP and Lipid Signaling and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include transcription factor binding.

UniProtKB/Swiss-Prot Summary for TPT1 Gene

Gene Wiki entry for TPT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TPT1 Gene

Genomics for TPT1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TPT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TPT1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TPT1

Top Transcription factor binding sites by QIAGEN in the TPT1 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • CREB
  • deltaCREB

Genomic Locations for TPT1 Gene

Genomic Locations for TPT1 Gene
chr13:45,333,471-45,341,284
(GRCh38/hg38)
Size:
7,814 bases
Orientation:
Minus strand
chr13:45,911,008-45,915,505
(GRCh37/hg19)
Size:
4,498 bases
Orientation:
Minus strand

Genomic View for TPT1 Gene

Genes around TPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPT1 Gene

Proteins for TPT1 Gene

  • Protein details for TPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13693-TCTP_HUMAN
    Recommended name:
    Translationally-controlled tumor protein
    Protein Accession:
    P13693
    Secondary Accessions:
    • B2R7E5
    • Q6YLS2
    • Q7Z4J4
    • Q8TBK7
    • Q96EE2
    • Q9UC70

    Protein attributes for TPT1 Gene

    Size:
    172 amino acids
    Molecular mass:
    19595 Da
    Quaternary structure:
    • Interacts with STEAP3.

    Three dimensional structures from OCA and Proteopedia for TPT1 Gene

    Alternative splice isoforms for TPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPT1 Gene

Post-translational modifications for TPT1 Gene

  • Ubiquitination at Lys102 and Lys164
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TPT1 Gene

Domains & Families for TPT1 Gene

Gene Families for TPT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TPT1 Gene

InterPro:
Blocks:
  • Translationally controlled tumor protein
ProtoNet:

Suggested Antigen Peptide Sequences for TPT1 Gene

GenScript: Design optimal peptide antigens:
  • Tumor protein, translationally-controlled 1 (Q5W0H4_HUMAN)
  • p23 (TCTP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P13693

UniProtKB/Swiss-Prot:

TCTP_HUMAN :
  • Belongs to the TCTP family.
Family:
  • Belongs to the TCTP family.
genes like me logo Genes that share domains with TPT1: view

Function for TPT1 Gene

Molecular function for TPT1 Gene

UniProtKB/Swiss-Prot Function:
Involved in calcium binding and microtubule stabilization.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection.
GENATLAS Biochemistry:
tumor protein,translationally controlled 1

Phenotypes From GWAS Catalog for TPT1 Gene

Gene Ontology (GO) - Molecular Function for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005509 calcium ion binding IBA,IDA 15162379
GO:0005515 protein binding IPI 16730713
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with TPT1: view
genes like me logo Genes that share phenotypes with TPT1: view

Animal Models for TPT1 Gene

MGI Knock Outs for TPT1:
  • Tpt1 Tpt1<tm1.1Atel>
  • Tpt1 Tpt1<tm1.1Yen>
  • Tpt1 Tpt1<tm1Kefu>

Animal Model Products

  • Taconic Biosciences Mouse Models for TPT1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPT1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPT1 Gene

Localization for TPT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPT1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
endosome 5
cytosol 5
plasma membrane 3
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 15162379
GO:0005615 extracellular space IDA 15319436
GO:0005623 cell IEA --
GO:0005634 nucleus IDA 11598139
GO:0005654 nucleoplasm IEA --
genes like me logo Genes that share ontologies with TPT1: view

Pathways & Interactions for TPT1 Gene

genes like me logo Genes that share pathways with TPT1: view

Pathways by source for TPT1 Gene

1 BioSystems pathway for TPT1 Gene
4 Cell Signaling Technology pathways for TPT1 Gene

SIGNOR curated interactions for TPT1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IC 15958728
GO:0006874 cellular calcium ion homeostasis IC 15958728
GO:0009615 response to virus IEP 16548883
GO:0019827 stem cell population maintenance IEA --
GO:0042981 regulation of apoptotic process NAS 15162379
genes like me logo Genes that share ontologies with TPT1: view

Drugs & Compounds for TPT1 Gene

(12) Drugs for TPT1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium citrate Approved, Investigational Pharma Target, ligand 0
Calcium Phosphate Approved Pharma Target, ligand 0
Calcium phosphate dihydrate Approved Pharma Target 0
Dihydroartemisinin Experimental, Investigational Pharma Target, ligand 115
Calcium Nutra 6556

(5) Additional Compounds for TPT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TPT1: view

Transcripts for TPT1 Gene

mRNA/cDNA for TPT1 Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPT1

Alternative Splicing Database (ASD) splice patterns (SP) for TPT1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:
SP7: -
SP8: - - - -
SP9: - -

Relevant External Links for TPT1 Gene

GeneLoc Exon Structure for
TPT1

Expression for TPT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPT1 Gene

mRNA differential expression in normal tissues according to GTEx for TPT1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.1).

Protein differential expression in normal tissues from HIPED for TPT1 Gene

This gene is overexpressed in Oral epithelium (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TPT1 Gene



Protein tissue co-expression partners for TPT1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TPT1

SOURCE GeneReport for Unigene cluster for TPT1 Gene:

Hs.374596

mRNA Expression by UniProt/SwissProt for TPT1 Gene:

P13693-TCTP_HUMAN
Tissue specificity: Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.

Evidence on tissue expression from TISSUES for TPT1 Gene

  • Nervous system(5)
  • Lung(5)
  • Pancreas(5)
  • Liver(5)
  • Intestine(4.9)
  • Skin(4.9)
  • Muscle(4.9)
  • Blood(4.9)
  • Stomach(4.8)
  • Eye(4.8)
  • Kidney(4.7)
  • Heart(4.7)
  • Bone(4.4)
  • Spleen(4)
  • Lymph node(3.5)
  • Thyroid gland(3.5)
  • Bone marrow(3.4)
  • Adrenal gland(3.4)
  • Gall bladder(3)
genes like me logo Genes that share expression patterns with TPT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPT1 Gene

Orthologs for TPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPT1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TPT1 30 31
  • 99.81 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TPT1 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 97 (a)
OneToMany
TPT1 30 31 31
  • 96.51 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia TPT1 30 31
  • 95.74 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tpt1 30
  • 90.7 (n)
Mouse
(Mus musculus)
Mammalia Tpt1 30 17 31
  • 90.31 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TPT1 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TPT1 30 31
  • 84.88 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TPT1 31
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tpt1 30
  • 70.54 (n)
Str.17076 30
African clawed frog
(Xenopus laevis)
Amphibia tpt1-prov 30
Zebrafish
(Danio rerio)
Actinopterygii tpt1 30 31
  • 68.23 (n)
OneToOne
tctp 30
Fruit Fly
(Drosophila melanogaster)
Insecta Tctp 30 31
  • 57.68 (n)
OneToOne
CG4800 32
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta TCTP_ANOGA 30
  • 56.69 (n)
Worm
(Caenorhabditis elegans)
Secernentea tct-1 30 31
  • 51.28 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA19 30 31 33
  • 56.29 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12716g 30
  • 55.49 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABR075C 30
  • 53.49 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons TCTP 30
  • 51.61 (n)
Rice
(Oryza sativa)
Liliopsida Os11g0660500 30
  • 51.81 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1F12.02c 30
  • 55.69 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU06464 30
  • 54.69 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5297 31
  • 39 (a)
OneToOne
Species where no ortholog for TPT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TPT1 Gene

ENSEMBL:
Gene Tree for TPT1 (if available)
TreeFam:
Gene Tree for TPT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TPT1: view image

Paralogs for TPT1 Gene

(1) SIMAP similar genes for TPT1 Gene using alignment to 6 proteins:

  • TCTP_HUMAN
  • E9PJF7_HUMAN
  • H0YCX0_HUMAN
  • J3KPG2_HUMAN
  • Q5W0H4_HUMAN
  • Q8TBK7_HUMAN
genes like me logo Genes that share paralogs with TPT1: view

No data available for Paralogs for TPT1 Gene

Variants for TPT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TPT1 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
734326 Benign: not provided 45,338,684(-) C/T SYNONYMOUS_VARIANT
rs3087989 - p.Val146Phe

Additional dbSNP identifiers (rs#s) for TPT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TPT1 Gene

Variant ID Type Subtype PubMed ID
nsv1046200 CNV gain 25217958
nsv477869 CNV novel sequence insertion 20440878
nsv510579 CNV deletion 20534489
nsv951078 CNV duplication 24416366
nsv977234 CNV duplication 23825009
nsv983582 CNV duplication 23825009

Variation tolerance for TPT1 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPT1 Gene

Disorders for TPT1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for TPT1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
urticaria
drug allergy
  • allergy drug
food allergy
  • food hypersensitivity
asthma
  • asthma, susceptibility to
allergic rhinitis
  • alrh
- elite association - COSMIC cancer census association via MalaCards
Search TPT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TPT1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TPT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPT1 Gene

Publications for TPT1 Gene

  1. The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells. (PMID: 15958728) Arcuri F … Cintorino M (Biology of reproduction 2005) 3 4 23
  2. Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity. (PMID: 15162379) Arcuri F … del Vecchio MT (The Prostate 2004) 3 4 23
  3. Plk phosphorylation regulates the microtubule-stabilizing protein TCTP. (PMID: 12167714) Yarm FR (Molecular and cellular biology 2002) 3 4 23
  4. Chromosomal localization of tumor protein, translationally-controlled 1 (TPT1) encoding the human histamine releasing factor (HRF) to 13q12-->q14. (PMID: 10343127) MacDonald SM … Jabs EW (Cytogenetics and cell genetics 1999) 2 3 23
  5. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. (PMID: 9059837) Sanchez JC … Hochstrasser D (Electrophoresis 1997) 3 4 23

Products for TPT1 Gene

  • Addgene plasmids for TPT1

Sources for TPT1 Gene