Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TPST2 Gene

Aliases for TPST2 Gene

  • Tyrosylprotein Sulfotransferase 2 2 3 4 5
  • Protein-Tyrosine Sulfotransferase 2 2 3
  • EC 4 56
  • TPST-2 3 4
  • Transport And Golgi Organization 13 Homolog B (Drosophila) 2
  • Transport And Golgi Organization 13 Homolog B 3
  • Tyrosylprotein Phosphotransferase 2 3
  • TANGO13B 3

External Ids for TPST2 Gene

Previous GeneCards Identifiers for TPST2 Gene

  • GC22M023617
  • GC22M025246
  • GC22M025238
  • GC22M026921
  • GC22M009869

Summaries for TPST2 Gene

Entrez Gene Summary for TPST2 Gene

  • The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPST2 Gene

TPST2 (Tyrosylprotein Sulfotransferase 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and protein-tyrosine sulfotransferase activity. An important paralog of this gene is TPST1.

UniProtKB/Swiss-Prot for TPST2 Gene

  • Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3-phosphoadenylyl sulfate (PAPS) as cosubstrate.

Additional gene information for TPST2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPST2 Gene

Genomics for TPST2 Gene

GeneHancer (GH) Regulatory Elements for TPST2 Gene

Promoters and enhancers for TPST2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I026584 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 566.6 +8.9 8858 6.2 ATF1 ARNT ARID4B SIN3A YY1 ZNF121 GLIS2 ZNF143 KLF7 FOS TPST2 CRYBA4 CRYBB1 HMGB1P10 MIR548J TFIP11
GH22I026564 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 554.9 +31.3 31271 1.1 ZNF316 SCRT2 ZFP36 RUNX3 TPST2 HMGB1P10
GH22I026596 Enhancer 0.6 ENCODE dbSUPER 550.8 -0.5 -515 1.2 SKI CBFA2T3 CREM TPST2 HPS4 SRRD MIATNB CRYBA4
GH22I026640 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -46.7 -46687 5.2 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 YY1 POLR2B ISCA2P1 TFIP11 MIATNB RPL15P22 TPST2 LOC100507599 CRYBB1 CRYBA4 HMGB1P10 MIR548J
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPST2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPST2 gene promoter:

Genomic Locations for TPST2 Gene

Genomic Locations for TPST2 Gene
74,735 bases
Minus strand

Genomic View for TPST2 Gene

Genes around TPST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPST2 Gene

Proteins for TPST2 Gene

  • Protein details for TPST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-tyrosine sulfotransferase 2
    Protein Accession:
    Secondary Accessions:
    • B3KQA7
    • Q6FI98
    • Q9H0V4

    Protein attributes for TPST2 Gene

    377 amino acids
    Molecular mass:
    41912 Da
    Quaternary structure:
    • Homodimer (PubMed:23481380). Can also form heterodimers with TPST1 (PubMed:25660941).
    • Substrate peptides must be flexible in order to adopt an L-shaped conformation in the deep binding cleft.

    Three dimensional structures from OCA and Proteopedia for TPST2 Gene

neXtProt entry for TPST2 Gene

Selected DME Specific Peptides for TPST2 Gene


Post-translational modifications for TPST2 Gene

  • N-glycosylated.
  • Glycosylation at isoforms=278, isoforms=285, posLast=286286, isoforms=343, and posLast=368368

Domains & Families for TPST2 Gene

Gene Families for TPST2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TPST2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein sulfotransferase family.
  • Belongs to the protein sulfotransferase family.
genes like me logo Genes that share domains with TPST2: view

Function for TPST2 Gene

Molecular function for TPST2 Gene

GENATLAS Biochemistry:
tyrosylprotein sulfotransferase 2,54/50kDa,catalyzing tyrosine o-sulfatin of proteins
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + protein tyrosine = adenosine 3,5-bisphosphate + protein tyrosine-O-sulfate.
UniProtKB/Swiss-Prot Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3-phosphoadenylyl sulfate (PAPS) as cosubstrate.

Enzyme Numbers (IUBMB) for TPST2 Gene

Phenotypes From GWAS Catalog for TPST2 Gene

Gene Ontology (GO) - Molecular Function for TPST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008476 protein-tyrosine sulfotransferase activity TAS,IEA --
GO:0016740 transferase activity IEA --
GO:0042803 protein homodimerization activity IPI 23481380
genes like me logo Genes that share ontologies with TPST2: view
genes like me logo Genes that share phenotypes with TPST2: view

Animal Models for TPST2 Gene

MGI Knock Outs for TPST2:

Clone Products

  • Addgene plasmids for TPST2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPST2 Gene

Localization for TPST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPST2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPST2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
lysosome 1

Gene Ontology (GO) - Cellular Components for TPST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IDA --
GO:0005794 Golgi apparatus IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPST2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TPST2 Gene

Pathways & Interactions for TPST2 Gene

SuperPathways for TPST2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006478 peptidyl-tyrosine sulfation IDA,IEA 9733778
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
genes like me logo Genes that share ontologies with TPST2: view

No data available for Pathways by source and SIGNOR curated interactions for TPST2 Gene

Drugs & Compounds for TPST2 Gene

(1) Drugs for TPST2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for TPST2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
genes like me logo Genes that share compounds with TPST2: view

Transcripts for TPST2 Gene

Unigene Clusters for TPST2 Gene

Tyrosylprotein sulfotransferase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for TPST2

Alternative Splicing Database (ASD) splice patterns (SP) for TPST2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -

Relevant External Links for TPST2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPST2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPST2 Gene

This gene is overexpressed in Pancreas (x12.3) and Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for TPST2 Gene

This gene is overexpressed in Pancreas (41.0) and Peripheral blood mononuclear cells (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPST2 Gene

Protein tissue co-expression partners for TPST2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPST2 Gene:


SOURCE GeneReport for Unigene cluster for TPST2 Gene:


mRNA Expression by UniProt/SwissProt for TPST2 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TPST2 Gene

  • Nervous system(4.5)
  • Intestine(4.2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with TPST2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TPST2 Gene

Orthologs for TPST2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPST2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPST2 33 34
  • 99.29 (n)
(Canis familiaris)
Mammalia TPST2 33 34
  • 92.22 (n)
(Bos Taurus)
Mammalia TPST2 33 34
  • 91.16 (n)
(Mus musculus)
Mammalia Tpst2 33 16 34
  • 89.01 (n)
(Rattus norvegicus)
Mammalia Tpst2 33
  • 88.39 (n)
(Monodelphis domestica)
Mammalia TPST2 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TPST2 34
  • 73 (a)
(Gallus gallus)
Aves TPST2 33 34
  • 77.72 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpst2 33
  • 66.67 (n)
Str.19735 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25665 33
(Danio rerio)
Actinopterygii tpst2 33 34
  • 65 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8743 33
fruit fly
(Drosophila melanogaster)
Insecta Tango13 34
  • 41 (a)
(Caenorhabditis elegans)
Secernentea Y111B2A.15 35
  • 63 (a)
tpst-1 34
  • 51 (a)
F42G9.8 35
  • 41 (a)
tpst-2 34
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
Species where no ortholog for TPST2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPST2 Gene

Gene Tree for TPST2 (if available)
Gene Tree for TPST2 (if available)

Paralogs for TPST2 Gene

Paralogs for TPST2 Gene

(1) SIMAP similar genes for TPST2 Gene using alignment to 7 proteins: Pseudogenes for TPST2 Gene

genes like me logo Genes that share paralogs with TPST2: view

Variants for TPST2 Gene

Sequence variations from dbSNP and Humsavar for TPST2 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000066025 -- 26,526,918(-) A/T intron_variant
rs1000134487 -- 26,550,081(-) T/C intron_variant
rs1000142670 -- 26,589,581(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000152034 -- 26,543,961(-) A/T intron_variant
rs1000196878 -- 26,589,736(-) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TPST2 Gene

Variant ID Type Subtype PubMed ID
nsv964616 CNV duplication 23825009
nsv7350 OTHER inversion 18451855
nsv1126627 CNV deletion 24896259
nsv1072206 CNV deletion 25765185
esv3893471 CNV loss 25118596
esv2758831 CNV loss 17122850
esv2724093 CNV deletion 23290073

Variation tolerance for TPST2 Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPST2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPST2 Gene

Disorders for TPST2 Gene

Additional Disease Information for TPST2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TPST2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPST2 Gene

Publications for TPST2 Gene

  1. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. (PMID: 9733778) Ouyang YB … Moore KL (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2. (PMID: 9736702) Beisswanger R … Huttner WB (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 58
  3. Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction. (PMID: 23481380) Teramoto T … Kakuta Y (Nature communications 2013) 3 4 58
  4. Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis. (PMID: 20460947) Rosendahl J … Sahin-Tóth M (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2010) 3 44 58
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58

Products for TPST2 Gene

Sources for TPST2 Gene

Loading form....