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Aliases for TPST1 Gene

Aliases for TPST1 Gene

  • Tyrosylprotein Sulfotransferase 1 2 3 4 5
  • EC 2.8.2.20 4 56
  • TPST-1 3 4
  • Transport And Golgi Organization 13 Homolog A (Drosophila) 2
  • Transport And Golgi Organization 13 Homolog A 3
  • Protein-Tyrosine Sulfotransferase 1 3
  • TANGO13A 3

External Ids for TPST1 Gene

Previous GeneCards Identifiers for TPST1 Gene

  • GC07P064310
  • GC07P065068
  • GC07P065081
  • GC07P065114
  • GC07P065308
  • GC07P065670
  • GC07P061856

Summaries for TPST1 Gene

GeneCards Summary for TPST1 Gene

TPST1 (Tyrosylprotein Sulfotransferase 1) is a Protein Coding gene. Diseases associated with TPST1 include Shwachman-Diamond Syndrome. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and protein-tyrosine sulfotransferase activity. An important paralog of this gene is TPST2.

UniProtKB/Swiss-Prot for TPST1 Gene

  • Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3-phosphoadenylyl sulfate (PAPS) as cosubstrate.

Additional gene information for TPST1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPST1 Gene

Genomics for TPST1 Gene

GeneHancer (GH) Regulatory Elements for TPST1 Gene

Promoters and enhancers for TPST1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I066204 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.4 427 2.2 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS SP3 SP5 TPST1 LOC100996437 ZNF92 PIR59576
GH07I066206 Enhancer 0.2 ENCODE 550.8 +2.0 1966 0.4 TPST1 ZNF92 PIR59576
GH07I066113 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.9 -90.1 -90094 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CRCP LOC100996437 VKORC1L1 GS1-124K5.4 LOC100420547 ENSG00000229180 TMEM248 CCT6P1 ENSG00000244657 GUSB
GH07I066075 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.7 -128.5 -128466 3.1 HDGF SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A YY1 POLR2B ZNF143 ASL LOC100996437 VKORC1L1 RABGEF1 TPST1 GC07P066070 ENSG00000249319
GH07I066170 Enhancer 0.9 Ensembl ENCODE 21.2 -34.3 -34320 1.1 ELF3 SAP130 CEBPG ZIC2 RAD21 THRB RARA TEAD3 RBAK TRIM24 VKORC1L1 TPST1 CCT6P1 LOC100420547 ENSG00000234185 GC07P066196
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPST1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPST1 gene promoter:

Genomic Locations for TPST1 Gene

Genomic Locations for TPST1 Gene
chr7:66,205,199-66,420,543
(GRCh38/hg38)
Size:
215,345 bases
Orientation:
Plus strand
chr7:65,670,186-65,885,530
(GRCh37/hg19)

Genomic View for TPST1 Gene

Genes around TPST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPST1 Gene

Proteins for TPST1 Gene

  • Protein details for TPST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60507-TPST1_HUMAN
    Recommended name:
    Protein-tyrosine sulfotransferase 1
    Protein Accession:
    O60507
    Secondary Accessions:
    • A4D2M0
    • Q6FGM7

    Protein attributes for TPST1 Gene

    Size:
    370 amino acids
    Molecular mass:
    42188 Da
    Quaternary structure:
    • Homodimer (PubMed:16859706, PubMed:28821720). Can also form heterodimers with TPST2 (PubMed:25660941).

    Three dimensional structures from OCA and Proteopedia for TPST1 Gene

neXtProt entry for TPST1 Gene

Selected DME Specific Peptides for TPST1 Gene

O60507:
  • GKLKQNLL
  • LGYDPYANPP
  • YEQLVLHP
  • ETRVIPRIL
  • DQVIKPVN
  • SYRDCLTKWNRAIETMY
  • YLSRLFPN
  • LCNKDPF
  • RLDEAGVTD
  • IFIGGVPRSGTTLMRAMLDAHP
  • DMAVIAPMLA
  • MVRDGRA
  • RKVTIAGFDL
  • ACLVISSVTVFYL
  • CHHRIEERSQP
  • ALSKWVGKIP
  • ANPPNYG

Post-translational modifications for TPST1 Gene

  • N-glycosylated.
  • Glycosylation at isoforms=46, posLast=6060, isoforms=199, isoforms=262, and posLast=286286
  • Modification sites at PhosphoSitePlus

Domains & Families for TPST1 Gene

Gene Families for TPST1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for TPST1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TPST1 Gene

Graphical View of Domain Structure for InterPro Entry

O60507

UniProtKB/Swiss-Prot:

TPST1_HUMAN :
  • Belongs to the protein sulfotransferase family.
Family:
  • Belongs to the protein sulfotransferase family.
genes like me logo Genes that share domains with TPST1: view

Function for TPST1 Gene

Molecular function for TPST1 Gene

GENATLAS Biochemistry:
tyrosylprotein sulfotransferase 1,54/50kDa,catalyzing tyrosine o-sulfatin of proteins
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + protein tyrosine = adenosine 3,5-bisphosphate + protein tyrosine-O-sulfate.
UniProtKB/Swiss-Prot Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3-phosphoadenylyl sulfate (PAPS) as cosubstrate.

Enzyme Numbers (IUBMB) for TPST1 Gene

Phenotypes From GWAS Catalog for TPST1 Gene

Gene Ontology (GO) - Molecular Function for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008476 protein-tyrosine sulfotransferase activity TAS,IEA --
GO:0016740 transferase activity IEA --
GO:0042803 protein homodimerization activity IPI 28821720
genes like me logo Genes that share ontologies with TPST1: view
genes like me logo Genes that share phenotypes with TPST1: view

Animal Models for TPST1 Gene

MGI Knock Outs for TPST1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TPST1

miRNA for TPST1 Gene

miRTarBase miRNAs that target TPST1

Clone Products

  • Addgene plasmids for TPST1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPST1 Gene

Localization for TPST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPST1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPST1 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IBA --
GO:0016020 membrane TAS 9501187
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane IDA 16859706
genes like me logo Genes that share ontologies with TPST1: view

Pathways & Interactions for TPST1 Gene

SuperPathways for TPST1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006478 peptidyl-tyrosine sulfation IDA,IEA 9501187
GO:0006954 inflammatory response TAS 9501187
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
genes like me logo Genes that share ontologies with TPST1: view

No data available for Pathways by source and SIGNOR curated interactions for TPST1 Gene

Drugs & Compounds for TPST1 Gene

(1) Drugs for TPST1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TPST1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with TPST1: view

Transcripts for TPST1 Gene

Unigene Clusters for TPST1 Gene

Tyrosylprotein sulfotransferase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for TPST1

Alternative Splicing Database (ASD) splice patterns (SP) for TPST1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - -
SP2: - - -
SP3:
SP4:
SP5: - -
SP6:

Relevant External Links for TPST1 Gene

GeneLoc Exon Structure for
TPST1
ECgene alternative splicing isoforms for
TPST1

Expression for TPST1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPST1 Gene

This gene is overexpressed in Bone (57.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPST1 Gene



Protein tissue co-expression partners for TPST1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPST1 Gene:

TPST1

SOURCE GeneReport for Unigene cluster for TPST1 Gene:

Hs.421194

mRNA Expression by UniProt/SwissProt for TPST1 Gene:

O60507-TPST1_HUMAN
Tissue specificity: Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for TPST1 Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with TPST1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPST1 Gene

Orthologs for TPST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPST1 33 34
  • 99.91 (n)
cow
(Bos Taurus)
Mammalia TPST1 33 34
  • 93.06 (n)
dog
(Canis familiaris)
Mammalia TPST1 33 34
  • 93.06 (n)
mouse
(Mus musculus)
Mammalia Tpst1 33 16 34
  • 89.28 (n)
rat
(Rattus norvegicus)
Mammalia Tpst1 33
  • 89.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TPST1 34
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPST1 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPST1 33 34
  • 80 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpst1 33
  • 76.81 (n)
zebrafish
(Danio rerio)
Actinopterygii tpst1 33 34
  • 73.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000900 33
  • 61.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tango13 33 34
  • 58.85 (n)
worm
(Caenorhabditis elegans)
Secernentea Y111B2A.15 35
  • 64 (a)
tpst-1 33 34
  • 60.98 (n)
F42G9.8 35
  • 39 (a)
tpst-2 34
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToMany
Species where no ortholog for TPST1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPST1 Gene

ENSEMBL:
Gene Tree for TPST1 (if available)
TreeFam:
Gene Tree for TPST1 (if available)

Paralogs for TPST1 Gene

Paralogs for TPST1 Gene

(1) SIMAP similar genes for TPST1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TPST1: view

Variants for TPST1 Gene

Sequence variations from dbSNP and Humsavar for TPST1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000007360 -- 66,341,149(+) G/A intron_variant
rs1000047648 -- 66,293,737(+) T/C intron_variant
rs1000055980 -- 66,254,192(+) GGGGG/GGGGGG intron_variant
rs1000079758 -- 66,323,021(+) T/C intron_variant
rs1000127791 -- 66,254,459(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TPST1 Gene

Variant ID Type Subtype PubMed ID
esv2063879 CNV deletion 18987734
esv2664145 CNV deletion 23128226
esv2677943 CNV deletion 23128226
esv2761079 CNV gain+loss 21179565
esv3365953 CNV insertion 20981092
esv3541801 CNV deletion 23714750
esv3571889 CNV loss 25503493
esv3613504 CNV loss 21293372
nsv1124221 CNV deletion 24896259
nsv507395 OTHER sequence alteration 20534489
nsv508458 CNV deletion 20534489

Variation tolerance for TPST1 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPST1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPST1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPST1 Gene

Disorders for TPST1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TPST1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
shwachman-diamond syndrome
  • sds
- elite association - COSMIC cancer census association via MalaCards
Search TPST1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TPST1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TPST1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPST1 Gene

Publications for TPST1 Gene

  1. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. (PMID: 9733778) Ouyang YB … Moore KL (The Journal of biological chemistry 1998) 3 4 22 58
  2. Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. (PMID: 9501187) Ouyang Yb … Moore KL (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
  3. Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1. (PMID: 28821720) Tanaka S … Kakuta Y (Scientific reports 2017) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58

Products for TPST1 Gene

  • Addgene plasmids for TPST1

Sources for TPST1 Gene

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