Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008] See more...

Aliases for TPRXL Gene

Aliases for TPRXL Gene

  • Tetrapeptide Repeat Homeobox Like (Pseudogene) 2 3
  • Tetrapeptide Repeat Homeobox Like 2 5
  • TPRX3P 2 3
  • Tetra-Peptide Repeat Homeobox-Like 3
  • Putative Protein TPRXL 4
  • FLJ35107 2
  • TPRXL 5

External Ids for TPRXL Gene

Previous GeneCards Identifiers for TPRXL Gene

  • GC03P013954
  • GC03P013978
  • GC03P013912

Summaries for TPRXL Gene

Entrez Gene Summary for TPRXL Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPRXL Gene

TPRXL (Tetrapeptide Repeat Homeobox Like (Pseudogene)) is a Pseudogene. Diseases associated with TPRXL include Transitional Meningioma.

Additional gene information for TPRXL Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TPRXL Gene

Genomics for TPRXL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TPRXL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J014122 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7 +188.0 187964 5.4 ARHGAP35 SP1 CREB1 PRDM10 REST ZNF512 SIX5 IKZF1 NFKBIZ ZNF692 CHCHD4 TMEM43 MN297957 CCDC174 XPC NR2C2 ENSG00000228242 VN1R20P TPRXL ENSG00000268279
GH03J013423 Enhancer 0.8 Ensembl dbSUPER 9.8 -512.5 -512473 2.4 NR2C1 HDAC1 GATAD2B NFE2 FOXA2 ZNF580 NR2C2 ZBTB17 NFIC ZFHX2 NUP210 TPRXL piR-32214-472 HDAC11
GH03J014132 Enhancer 0.8 Ensembl ENCODE dbSUPER 6.9 +196.1 196095 1.2 HNRNPL SAP130 HNF4A TEAD3 SP5 ENSG00000268279 XPC LSM3 CHCHD4 TPRXL MN297957 TMEM43
GH03J014016 Enhancer 0.7 Ensembl ENCODE 7.3 +79.9 79934 1.3 ZIC2 KLF9 RFX1 NFIC NFIB KLF17 NFIA GLIS1 IKZF1 KLF1 TPRXL CHCHD4 piR-39099-152 piR-52879-010 lnc-TMEM43-2 WNT7A
GH03J014000 Enhancer 0.7 Ensembl ENCODE 7.3 +64.0 63976 1.9 NFE2 ZEB1 ZSCAN5C BCL11A ATF4 CEBPG ATF3 PRDM6 TRIM24 SP7 WNT7A TPRXL XPC VN1R20P CHCHD4 piR-52879-010 piR-39099-152 lnc-TMEM43-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TPRXL on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the TPRXL gene promoter:
  • AML1a
  • c-Ets-1
  • Cart-1
  • Cdc5
  • CUTL1
  • GR-beta
  • MZF-1
  • p53
  • YY1

Genomic Locations for TPRXL Gene

Genomic Locations for TPRXL Gene
145,539 bases
Plus strand
145,556 bases
Plus strand

Genomic View for TPRXL Gene

Genes around TPRXL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRXL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRXL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRXL Gene

Proteins for TPRXL Gene

  • Protein details for TPRXL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative protein TPRXL
    Protein Accession:
    Secondary Accessions:
    • Q8NAM5

    Protein attributes for TPRXL Gene

    258 amino acids
    Molecular mass:
    24139 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPRXL Gene

Post-translational modifications for TPRXL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TPRXL Gene

Domains & Families for TPRXL Gene

Gene Families for TPRXL Gene

Protein Domains for TPRXL Gene


Suggested Antigen Peptide Sequences for TPRXL Gene

GenScript: Design optimal peptide antigens:
  • Putative protein TPRXL (TPRXL_HUMAN)
genes like me logo Genes that share domains with TPRXL: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TPRXL Gene

Function for TPRXL Gene

Phenotypes From GWAS Catalog for TPRXL Gene

Phenotypes for TPRXL Gene

GenomeRNAi human phenotypes for TPRXL:
genes like me logo Genes that share phenotypes with TPRXL: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPRXL Gene

Localization for TPRXL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPRXL gene
Compartment Confidence
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TPRXL Gene

Pathways & Interactions for TPRXL Gene

PathCards logo

SuperPathways for TPRXL Gene

No Data Available

Interacting Proteins for TPRXL Gene

Selected Interacting proteins: Q17RH7-TPRXL_HUMAN for TPRXL Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TPRXL Gene


No data available for Pathways by source and SIGNOR curated interactions for TPRXL Gene

Drugs & Compounds for TPRXL Gene

No Compound Related Data Available

Transcripts for TPRXL Gene

mRNA/cDNA for TPRXL Gene

5 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPRXL Gene

No ASD Table

Relevant External Links for TPRXL Gene

GeneLoc Exon Structure for

Expression for TPRXL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPRXL Gene

mRNA differential expression in normal tissues according to GTEx for TPRXL Gene

This gene is overexpressed in Esophagus - Mucosa (x18.2), Vagina (x6.0), and Testis (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TPRXL

SOURCE GeneReport for Unigene cluster for TPRXL Gene:

genes like me logo Genes that share expression patterns with TPRXL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPRXL Gene

Orthologs for TPRXL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPRXL Gene

Organism Taxonomy Gene Similarity Type Details
(Triticum aestivum)
Liliopsida Ta.22819 30
Species where no ortholog for TPRXL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TPRXL Gene

Gene Tree for TPRXL (if available)
Gene Tree for TPRXL (if available)
Evolutionary constrained regions (ECRs) for TPRXL: view image

Paralogs for TPRXL Gene

No data available for Paralogs for TPRXL Gene

Variants for TPRXL Gene

Structural Variations from Database of Genomic Variants (DGV) for TPRXL Gene

Variant ID Type Subtype PubMed ID
esv2584514 CNV insertion 19546169
esv2629351 CNV deletion 19546169
esv2724945 CNV deletion 23290073
esv2763224 CNV loss 21179565
esv3331951 CNV duplication 20981092
esv34163 CNV loss 18971310
esv3595356 CNV loss 21293372
esv3595357 CNV loss 21293372
esv3595358 CNV loss 21293372
esv3595359 CNV loss 21293372
nsv1010313 CNV loss 25217958
nsv1011766 CNV gain 25217958
nsv3711 CNV insertion 18451855
nsv512797 CNV insertion 21212237
nsv526467 CNV loss 19592680

Variation tolerance for TPRXL Gene

Gene Damage Index Score: 10.74; 91.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPRXL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Additional dbSNP identifiers (rs#s) for TPRXL Gene

Disorders for TPRXL Gene

MalaCards: The human disease database

(1) MalaCards diseases for TPRXL Gene - From: DISEASES

Disorder Aliases PubMed IDs
transitional meningioma
  • transitional meningioma
- elite association - COSMIC cancer census association via MalaCards
Search TPRXL in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TPRXL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPRXL Gene

Publications for TPRXL Gene

  1. Whole exome sequencing in a case of sporadic multiple meningioma reveals shared NF2, FAM109B, and TPRXL mutations, together with unique SMARCB1 alterations in a subset of tumor nodules. (PMID: 25981829) Torres-Martín M … Rey JA (Cancer genetics 2015) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. (PMID: 22116950) Schuh-Huerta SM … Reijo Pera RA (Human reproduction (Oxford, England) 2012) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for TPRXL Gene

Sources for TPRXL Gene