Aliases for TPRX1 Gene
Aliases for TPRX1 Gene
External Ids for TPRX1 Gene
- HGNC: 32174
- Entrez Gene: 284355
- Ensembl: ENSG00000178928
- OMIM: 611166
- UniProtKB: Q8N7U7
Previous GeneCards Identifiers for TPRX1 Gene
- GC19M052998
- GC19M048304
- GC19M044730
Summaries for TPRX1 Gene
-
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008]
GeneCards Summary for TPRX1 Gene
TPRX1 (Tetrapeptide Repeat Homeobox 1) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HESX1.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPRX1 Gene
Genomics for TPRX1 Gene
GeneHancer (GH) Regulatory Elements for TPRX1 Gene
Promoters and enhancers for TPRX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TPRX1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TPRX1 Gene
Genomic Locations for TPRX1 Gene
- chr19:47,801,243-47,819,051
- (GRCh38/hg38)
- Size:
- 17,809 bases
- Orientation:
- Minus strand
- chr19:48,304,500-48,322,308
- (GRCh37/hg19)
Genomic View for TPRX1 Gene
Genes around TPRX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by Entrez Gene
- 19q13.33 by HGNC
- 19q13.33 by Ensembl
TPRX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TPRX1 Gene
Proteins for TPRX1 Gene
-
Protein details for TPRX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N7U7-TPRX1_HUMAN
- Recommended name:
- Tetra-peptide repeat homeobox protein 1
- Protein Accession:
- Q8N7U7
- A5D8Y3
- B2RPL5
Protein attributes for TPRX1 Gene
- Size:
- 411 amino acids
- Molecular mass:
- 40603 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for TPRX1 Gene
No Post-translational modifications
Other Protein References for TPRX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TPRX1
- Novus Biologicals Antibodies for TPRX1
- Invitrogen Antibodies for TPRX1
- Search GeneTex for Antibodies for TPRX1
-
Boster Bio Antibodies for TPRX1
Protein Products
-
OriGene Purified Proteins for TPRX1
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- Search GeneTex for Proteins for TPRX1
Assay Products
No data available for DME Specific Peptides for TPRX1 Gene
Domains & Families for TPRX1 Gene
Gene Families for TPRX1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for TPRX1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TPRX1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TPRX1 Gene
Function for TPRX1 Gene
Phenotypes From GWAS Catalog for TPRX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISM | 19274049 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for TPRX1 Gene
- GenomeRNAi human phenotypes for TPRX1:
-
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Decreased influenza A virus infection
- Decreased Aire reporter expression
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mitotic spindle defects
- Decreased IL-8 secretion
- Increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TPRX1
-
CRISPR Products
-
OriGene CRISPR knockouts for TPRX1
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- genomics-online: gRNA clones - Search results for 35 available TPRX1 gene related products
- Overview of 35 available TPRX1 gene related products
- Applied Biological Materials CRISPR for TPRX1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TPRX1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TPRX1
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- genomics-online: shRNA clones - Search results for 35 available TPRX1 gene related products
- Overview of 35 available TPRX1 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TPRX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TPRX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TPRX1
- Applied Biological Materials Clones for TPRX1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TPRX1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPRX1 Gene
Localization for TPRX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TPRX1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| mitochondrion | 2 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TPRX1 Gene
Pathways & Interactions for TPRX1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Preimplantation Embryo | ||
Pathways by source for TPRX1 Gene
1 BioSystems pathway for TPRX1 Gene
Interacting Proteins for TPRX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
No data available for SIGNOR curated interactions for TPRX1 Gene
Transcripts for TPRX1 Gene
mRNA/cDNA for TPRX1 Gene
- (5) Selected AceView cDNA sequences:
- (5) Additional mRNA sequences :
- (1) REFSEQ mRNAs :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000322175 1924 bps (uc002php.3)
- ENST00000535759 2059 bps (uc061aon.1)
- ENST00000543508 1526 bps (uc061aoo.1)
Unigene Clusters for TPRX1 Gene
- Tetra-peptide repeat homeobox 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TPRX1
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- genomics-online: gRNA clones - Search results for 35 available TPRX1 gene related products
- Overview of 35 available TPRX1 gene related products
- Applied Biological Materials CRISPR for TPRX1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TPRX1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TPRX1
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPRX1
- genomics-online: shRNA clones - Search results for 35 available TPRX1 gene related products
- Overview of 35 available TPRX1 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TPRX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TPRX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TPRX1
- Applied Biological Materials Clones for TPRX1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TPRX1 Gene
mRNA differential expression in normal tissues according to GTEx for TPRX1 Gene
This gene is overexpressed in Testis (x42.2).
NURSA nuclear receptor signaling pathways regulating expression of TPRX1 Gene:
TPRX1SOURCE GeneReport for Unigene cluster for TPRX1 Gene:
Hs.629812Primer Products
-
OriGene qPCR primer pairs for TPRX1
- genomics-online: primer clones - Search results for 35 available TPRX1 gene related products
- Overview of 35 available TPRX1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPRX1 Gene
Orthologs for TPRX1 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TPRX1 34 |
|
OneToOne |
- Species where no ortholog for TPRX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for TPRX1 Gene
- ENSEMBL:
- Gene Tree for TPRX1 (if available)
- TreeFam:
- Gene Tree for TPRX1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TPRX1: view image
Paralogs for TPRX1 Gene
Variants for TPRX1 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000777598 | -- | 47,801,393(-) | A/G | 3_prime_UTR_variant | |
| rs1000862751 | -- | 47,805,122(-) | A/G | upstream_transcript_variant | |
| rs1001149556 | -- | 47,803,036(-) | T/G | intron_variant | |
| rs1002481033 | -- | 47,804,329(-) | A/C | upstream_transcript_variant | |
| rs1002815081 | -- | 47,803,099(-) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv653e199 | CNV | deletion | 23128226 |
| esv2718667 | CNV | deletion | 23290073 |
| esv3644559 | CNV | gain | 21293372 |
| esv3644564 | CNV | loss | 21293372 |
| nsv1058622 | CNV | gain | 25217958 |
| nsv1062085 | CNV | gain | 25217958 |
| nsv1066097 | CNV | gain | 25217958 |
| nsv1066782 | CNV | loss | 25217958 |
| nsv1071543 | CNV | deletion | 25765185 |
| nsv428367 | CNV | gain+loss | 18775914 |
| nsv458715 | CNV | gain | 19166990 |
| nsv520073 | CNV | gain | 19592680 |
| nsv579897 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.48;
85.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TPRX1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TPRX1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPRX1 Gene
Disorders for TPRX1 Gene
Additional Disease Information for TPRX1
No disorders were found for TPRX1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPRX1 Gene
Publications for TPRX1 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 58
- Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth HA … Holland PW (Gene 2007) 3 58
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
Products for TPRX1 Gene
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- VectorBuilder custom plasmid, inducible vectors for TPRX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TPRX1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available TPRX1 related products ranked by validation data
- antibodies-online: Search results for available TPRX1 related products ranked by validation data
- antibodies-online: Search results for available TPRX1 related products ranked by validation data
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- genomics-online: cdna clones - Search results for 35 available TPRX1 gene related products
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Sources for TPRX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio