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Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008]
TPRX1 (Tetrapeptide Repeat Homeobox 1) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0003677 | DNA binding | IEA | -- |
GO:0043565 | sequence-specific DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Preimplantation Embryo |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TPRX1 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv653e199 | CNV | deletion | 23128226 |
esv2718667 | CNV | deletion | 23290073 |
esv3644559 | CNV | gain | 21293372 |
esv3644564 | CNV | loss | 21293372 |
nsv1058622 | CNV | gain | 25217958 |
nsv1062085 | CNV | gain | 25217958 |
nsv1066097 | CNV | gain | 25217958 |
nsv1066782 | CNV | loss | 25217958 |
nsv1071543 | CNV | deletion | 25765185 |
nsv428367 | CNV | gain+loss | 18775914 |
nsv458715 | CNV | gain | 19166990 |
nsv520073 | CNV | gain | 19592680 |
nsv579897 | CNV | gain | 21841781 |
No disorders were found for TPRX1 Gene.