Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008] See more...

Aliases for TPRX1 Gene

Aliases for TPRX1 Gene

  • Tetrapeptide Repeat Homeobox 1 2 3 5
  • Tetra-Peptide Repeat Homeobox Protein 1 3 4
  • Tetra-Peptide Repeat Homeobox 1 3
  • CRX Like Homeobox 2 3
  • FLJ40321 2
  • TPRX1 5
  • TPRX 3

External Ids for TPRX1 Gene

Previous GeneCards Identifiers for TPRX1 Gene

  • GC19M052998
  • GC19M048304
  • GC19M044730

Summaries for TPRX1 Gene

Entrez Gene Summary for TPRX1 Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPRX1 Gene

TPRX1 (Tetrapeptide Repeat Homeobox 1) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding.

Additional gene information for TPRX1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TPRX1 Gene

Genomics for TPRX1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TPRX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J047819 Enhancer 0.7 Ensembl ENCODE 600.7 -1.1 -1050 1.4 ARNT IRF4 GLIS1 BHLHE40 SP1 SPI1 MCM2 IKZF1 CRX TPRX1 lnc-SELENOW-3 lnc-CRX-1 ZC3H4 SELENOW LINC01595 SULT2A1
GH19J047775 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 +40.3 40325 5.5 SP1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 LEF1 IKZF1 KDM1A ZNF692 SELENOW lnc-NOP53-2 BICRA ZC3H4 GRWD1 NOP53 RASIP1 SEC1P MEIS3 NAPA
GH19J047813 Enhancer 0.8 Ensembl ENCODE 0.4 +5.1 5050 0.8 CTCF REST KLF9 ZBTB48 KLF8 SMC3 RAD21 VEZF1 ZNF143 KLF10 TPRX1 RPL23AP80 SELENOW
GH19J047789 Enhancer 0.9 FANTOM5 ENCODE 0.3 +28.5 28526 1.1 CTCF PRDM10 PATZ1 REST POLR2A TRIM22 ZNF311 ZNF444 YY1 ZNF662 CABP5 CRX ZC3H4 NOP53-AS1 GRWD1 RASIP1 BICRA NOP53 ENSG00000271150 RF00017-3039
GH19J047788 Enhancer 1 ENCODE dbSUPER 0.3 +30.3 30268 1.1 CTCF TEAD4 IKZF1 KDM1A TARDBP JUND ZNF143 REST NR2C1 ZNF24 RF00017-3039 SELENOW ZC3H4 NOP53-AS1 ENSG00000271150 lnc-SELENOW-2 TPRX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TPRX1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TPRX1

Top Transcription factor binding sites by QIAGEN in the TPRX1 gene promoter:
  • aMEF-2
  • AP-1
  • ATF-2
  • c-Jun
  • GATA-3
  • Ik-2
  • MEF-2
  • MEF-2A
  • STAT3

Genomic Locations for TPRX1 Gene

Genomic Locations for TPRX1 Gene
chr19:47,801,243-47,819,051
(GRCh38/hg38)
Size:
17,809 bases
Orientation:
Minus strand
chr19:48,304,500-48,322,308
(GRCh37/hg19)
Size:
17,809 bases
Orientation:
Minus strand

Genomic View for TPRX1 Gene

Genes around TPRX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRX1 Gene

Proteins for TPRX1 Gene

  • Protein details for TPRX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7U7-TPRX1_HUMAN
    Recommended name:
    Tetra-peptide repeat homeobox protein 1
    Protein Accession:
    Q8N7U7
    Secondary Accessions:
    • A5D8Y3
    • B2RPL5

    Protein attributes for TPRX1 Gene

    Size:
    411 amino acids
    Molecular mass:
    40603 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPRX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPRX1 Gene

Post-translational modifications for TPRX1 Gene

No Post-translational modifications

Other Protein References for TPRX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPRX1 Gene

Domains & Families for TPRX1 Gene

Gene Families for TPRX1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TPRX1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TPRX1 Gene

GenScript: Design optimal peptide antigens:
  • Tetra-peptide repeat homeobox protein 1 (TPRX1_HUMAN)
genes like me logo Genes that share domains with TPRX1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TPRX1 Gene

Function for TPRX1 Gene

Gene Ontology (GO) - Molecular Function for TPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with TPRX1: view
genes like me logo Genes that share phenotypes with TPRX1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPRX1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPRX1 Gene

Localization for TPRX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRX1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPRX1 gene
Compartment Confidence
nucleus 4
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TPRX1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TPRX1 Gene

Pathways & Interactions for TPRX1 Gene

PathCards logo

SuperPathways for TPRX1 Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with TPRX1: view

Pathways by source for TPRX1 Gene

1 BioSystems pathway for TPRX1 Gene

Gene Ontology (GO) - Biological Process for TPRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with TPRX1: view

No data available for SIGNOR curated interactions for TPRX1 Gene

Drugs & Compounds for TPRX1 Gene

No Compound Related Data Available

Transcripts for TPRX1 Gene

mRNA/cDNA for TPRX1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPRX1

Alternative Splicing Database (ASD) splice patterns (SP) for TPRX1 Gene

No ASD Table

Relevant External Links for TPRX1 Gene

GeneLoc Exon Structure for
TPRX1

Expression for TPRX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPRX1 Gene

mRNA differential expression in normal tissues according to GTEx for TPRX1 Gene

This gene is overexpressed in Testis (x42.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TPRX1

SOURCE GeneReport for Unigene cluster for TPRX1 Gene:

Hs.629812
genes like me logo Genes that share expression patterns with TPRX1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPRX1 Gene

Orthologs for TPRX1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TPRX1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TPRX1 31
  • 76 (a)
OneToOne
Species where no ortholog for TPRX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TPRX1 Gene

ENSEMBL:
Gene Tree for TPRX1 (if available)
TreeFam:
Gene Tree for TPRX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TPRX1: view image

Paralogs for TPRX1 Gene

(6) SIMAP similar genes for TPRX1 Gene using alignment to 3 proteins:

  • TPRX1_HUMAN
  • B7ZMM8_HUMAN
  • D2CFI5_HUMAN

Pseudogenes.org Pseudogenes for TPRX1 Gene

genes like me logo Genes that share paralogs with TPRX1: view

No data available for Paralogs for TPRX1 Gene

Variants for TPRX1 Gene

Additional dbSNP identifiers (rs#s) for TPRX1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TPRX1 Gene

Variant ID Type Subtype PubMed ID
dgv653e199 CNV deletion 23128226
esv2718667 CNV deletion 23290073
esv3644559 CNV gain 21293372
esv3644564 CNV loss 21293372
nsv1058622 CNV gain 25217958
nsv1062085 CNV gain 25217958
nsv1066097 CNV gain 25217958
nsv1066782 CNV loss 25217958
nsv1071543 CNV deletion 25765185
nsv428367 CNV gain+loss 18775914
nsv458715 CNV gain 19166990
nsv520073 CNV gain 19592680
nsv579897 CNV gain 21841781

Variation tolerance for TPRX1 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPRX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPRX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TPRX1 Gene

Disorders for TPRX1 Gene

No disorders were found for TPRX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPRX1 Gene

Publications for TPRX1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3
  4. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth HA … Holland PW (Gene 2007) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for TPRX1 Gene

Sources for TPRX1 Gene