Aliases for TPRG1L Gene

Aliases for TPRG1L Gene

  • Tumor Protein P63 Regulated 1 Like 2 3 5
  • Mossy Fiber Terminal-Associated Vertebrate-Specific Presynaptic Protein 3 4
  • Tumor Protein P63-Regulated Gene 1-Like Protein 3 4
  • Family With Sequence Similarity 79, Member A 2 3
  • FAM79A 3 4
  • Protein FAM79A 4
  • RP11-46F15.3 3
  • H-Mover 3
  • Mover 3
  • MOVER 4

External Ids for TPRG1L Gene

Previous HGNC Symbols for TPRG1L Gene

  • FAM79A

Previous GeneCards Identifiers for TPRG1L Gene

  • GC01P003532
  • GC01P002837

Summaries for TPRG1L Gene

GeneCards Summary for TPRG1L Gene

TPRG1L (Tumor Protein P63 Regulated 1 Like) is a Protein Coding gene. Diseases associated with TPRG1L include Transvestism. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is TPRG1.

UniProtKB/Swiss-Prot Summary for TPRG1L Gene

  • Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release.

Additional gene information for TPRG1L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TPRG1L Gene

Genomics for TPRG1L Gene

GeneHancer (GH) Regulatory Elements for TPRG1L Gene

Promoters and enhancers for TPRG1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TPRG1L on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TPRG1L

Top Transcription factor binding sites by QIAGEN in the TPRG1L gene promoter:
  • AREB6
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • NRSF form 1
  • NRSF form 2
  • p53

Genomic Locations for TPRG1L Gene

Genomic Locations for TPRG1L Gene
chr1:3,624,992-3,630,131
(GRCh38/hg38)
Size:
5,140 bases
Orientation:
Plus strand
chr1:3,541,556-3,546,695
(GRCh37/hg19)
Size:
5,140 bases
Orientation:
Plus strand

Genomic View for TPRG1L Gene

Genes around TPRG1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRG1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRG1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRG1L Gene

Proteins for TPRG1L Gene

  • Protein details for TPRG1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T0D9-TPRGL_HUMAN
    Recommended name:
    Tumor protein p63-regulated gene 1-like protein
    Protein Accession:
    Q5T0D9
    Secondary Accessions:
    • A8K1K4
    • Q8WV04

    Protein attributes for TPRG1L Gene

    Size:
    272 amino acids
    Molecular mass:
    30212 Da
    Quaternary structure:
    • Forms homomultimers. Multimerization appears to be important for presynaptic targeting. Interacts with BSN.

    Alternative splice isoforms for TPRG1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPRG1L Gene

Post-translational modifications for TPRG1L Gene

  • Phosphorylated. Phosphorylation promotes association with synaptic vesicle membranes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPRG1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPRG1L Gene

Domains & Families for TPRG1L Gene

Gene Families for TPRG1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TPRG1L Gene

Suggested Antigen Peptide Sequences for TPRG1L Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55125 (B4DPH8_HUMAN)
  • Protein FAM79A (TPRGL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T0D9

UniProtKB/Swiss-Prot:

TPRGL_HUMAN :
  • Belongs to the TPRG1 family.
Family:
  • Belongs to the TPRG1 family.
genes like me logo Genes that share domains with TPRG1L: view

Function for TPRG1L Gene

Molecular function for TPRG1L Gene

UniProtKB/Swiss-Prot Function:
Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release.

Gene Ontology (GO) - Molecular Function for TPRG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with TPRG1L: view
genes like me logo Genes that share phenotypes with TPRG1L: view

Animal Model Products

CRISPR Products

miRNA for TPRG1L Gene

miRTarBase miRNAs that target TPRG1L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPRG1L

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPRG1L Gene

Localization for TPRG1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRG1L Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic active zone.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPRG1L gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TPRG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0008021 synaptic vesicle ISS 17869247
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with TPRG1L: view

Pathways & Interactions for TPRG1L Gene

PathCards logo

SuperPathways for TPRG1L Gene

No Data Available

Interacting Proteins for TPRG1L Gene

Selected Interacting proteins: Q5T0D9-TPRGL_HUMAN for TPRG1L Gene via IID

;

Gene Ontology (GO) - Biological Process for TPRG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0051966 regulation of synaptic transmission, glutamatergic ISS --
genes like me logo Genes that share ontologies with TPRG1L: view

No data available for Pathways by source and SIGNOR curated interactions for TPRG1L Gene

Drugs & Compounds for TPRG1L Gene

No Compound Related Data Available

Transcripts for TPRG1L Gene

mRNA/cDNA for TPRG1L Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPRG1L

Alternative Splicing Database (ASD) splice patterns (SP) for TPRG1L Gene

No ASD Table

Relevant External Links for TPRG1L Gene

GeneLoc Exon Structure for
TPRG1L

Expression for TPRG1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPRG1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPRG1L Gene

This gene is overexpressed in Frontal cortex (24.3) and Brain (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TPRG1L Gene



Protein tissue co-expression partners for TPRG1L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TPRG1L

SOURCE GeneReport for Unigene cluster for TPRG1L Gene:

Hs.20529

Evidence on tissue expression from TISSUES for TPRG1L Gene

  • Nervous system(4.8)
  • Muscle(2.5)
  • Heart(2.3)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with TPRG1L: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPRG1L Gene

Orthologs for TPRG1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPRG1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPRG1L 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPRG1L 31
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPRG1L 31
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tprgl 17 31 30
  • 87.09 (n)
rat
(Rattus norvegicus)
Mammalia Tprg1l 30
  • 86.59 (n)
cow
(Bos Taurus)
Mammalia TPRG1L 31 30
  • 85.29 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPRG1L 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPRG1L 31 30
  • 77.35 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tprg1l 30
  • 71.49 (n)
Str.11829 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.23748 30
zebrafish
(Danio rerio)
Actinopterygii tprg1l 31 30
  • 67.77 (n)
OneToOne
Dr.15200 30
Species where no ortholog for TPRG1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPRG1L Gene

ENSEMBL:
Gene Tree for TPRG1L (if available)
TreeFam:
Gene Tree for TPRG1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TPRG1L: view image

Paralogs for TPRG1L Gene

Paralogs for TPRG1L Gene

(1) SIMAP similar genes for TPRG1L Gene using alignment to 1 proteins:

  • TPRGL_HUMAN

Pseudogenes.org Pseudogenes for TPRG1L Gene

genes like me logo Genes that share paralogs with TPRG1L: view

Variants for TPRG1L Gene

Additional dbSNP identifiers (rs#s) for TPRG1L Gene

Structural Variations from Database of Genomic Variants (DGV) for TPRG1L Gene

Variant ID Type Subtype PubMed ID
esv2758915 CNV gain 17122850
esv3585042 CNV gain 21293372
esv3585044 CNV gain 21293372
esv3585045 CNV gain 21293372
nsv1001715 CNV loss 25217958
nsv1012423 CNV gain 25217958
nsv470687 CNV loss 18288195
nsv951959 CNV deletion 24416366

Variation tolerance for TPRG1L Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPRG1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPRG1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TPRG1L Gene

Disorders for TPRG1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for TPRG1L Gene - From: DISEASES

Disorder Aliases PubMed IDs
transvestism
  • cross dresser
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TPRG1L

genes like me logo Genes that share disorders with TPRG1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPRG1L Gene

Publications for TPRG1L Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for TPRG1L Gene

Sources for TPRG1L Gene