Aliases for TPRG1 Gene

Aliases for TPRG1 Gene

  • Tumor Protein P63 Regulated 1 2 3 5
  • Family With Sequence Similarity 79, Member B 2 3
  • Tumor Protein P63-Regulated Gene 1 Protein 3 4
  • FAM79B 3 4
  • Protein FAM79B 4

External Ids for TPRG1 Gene

Previous HGNC Symbols for TPRG1 Gene

  • FAM79B

Previous GeneCards Identifiers for TPRG1 Gene

  • GC03P190375
  • GC03P188665
  • GC03P186294

Summaries for TPRG1 Gene

GeneCards Summary for TPRG1 Gene

TPRG1 (Tumor Protein P63 Regulated 1) is a Protein Coding gene. Diseases associated with TPRG1 include Hemangioma Of Spleen and Mixed Liposarcoma. An important paralog of this gene is TPRG1L.

Additional gene information for TPRG1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TPRG1 Gene

Genomics for TPRG1 Gene

GeneHancer (GH) Regulatory Elements for TPRG1 Gene

Promoters and enhancers for TPRG1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J188945 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.6 1595 6.6 ZNF217 EP300 CTCF TCF12 USF1 PHF8 JUND TEAD4 FOS ZIC2 TPRG1-AS1 TPRG1 lnc-LPP-4
GH03J189171 Promoter/Enhancer 0.5 EPDnew Ensembl 500.1 +224.8 224787 0.4 TPRG1 piR-44110-044 lnc-LPP-6
GH03J188899 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -46.0 -46013 3.6 FOS JUN JUND EP300 FOXP2 TCF7L2 GATA2 BHLHE40 MAFK POLR2A TPRG1 TPRG1-AS1 lnc-LPP-2 piR-56186-046
GH03J188914 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 11.1 -32.4 -32374 0.3 FOS NR2F2 JUND GATA2 BHLHE40 ATF3 TPRG1 TPRG1-AS1 piR-56186-046 lnc-LPP-2
GH03J188915 Enhancer 0.7 ENCODE dbSUPER 11.1 -31.9 -31927 0.2 FOXA2 JUND BATF RAD21 RXRA MAX HNF4A HNF4G ATF3 SP1 TPRG1 TPRG1-AS1 piR-56186-046 lnc-LPP-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TPRG1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TPRG1

Top Transcription factor binding sites by QIAGEN in the TPRG1 gene promoter:
  • FOXI1
  • FOXO1
  • FOXO1a
  • HFH-1
  • MyoD
  • Pbx1a
  • POU3F2
  • PPAR-alpha
  • RSRFC4
  • TBP

Genomic Locations for TPRG1 Gene

Genomic Locations for TPRG1 Gene
378,091 bases
Plus strand
378,091 bases
Plus strand

Genomic View for TPRG1 Gene

Genes around TPRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRG1 Gene

Proteins for TPRG1 Gene

  • Protein details for TPRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor protein p63-regulated gene 1 protein
    Protein Accession:

    Protein attributes for TPRG1 Gene

    275 amino acids
    Molecular mass:
    31230 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPRG1 Gene

Post-translational modifications for TPRG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TPRG1 Gene

Domains & Families for TPRG1 Gene

Gene Families for TPRG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TPRG1 Gene

Suggested Antigen Peptide Sequences for TPRG1 Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM79B (TPRG1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPRG1 family.
  • Belongs to the TPRG1 family.
genes like me logo Genes that share domains with TPRG1: view

Function for TPRG1 Gene

Phenotypes From GWAS Catalog for TPRG1 Gene

Phenotypes for TPRG1 Gene

genes like me logo Genes that share phenotypes with TPRG1: view

Animal Model Products

CRISPR Products

miRNA for TPRG1 Gene

miRTarBase miRNAs that target TPRG1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPRG1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPRG1 Gene

Localization for TPRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRG1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPRG1 gene
Compartment Confidence
cytoskeleton 2
nucleus 1
cytosol 1
plasma membrane 0
extracellular 0
mitochondrion 0
peroxisome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TPRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with TPRG1: view

Pathways & Interactions for TPRG1 Gene

PathCards logo

SuperPathways for TPRG1 Gene

No Data Available

Interacting Proteins for TPRG1 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000341031 for TPRG1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TPRG1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TPRG1 Gene

Drugs & Compounds for TPRG1 Gene

No Compound Related Data Available

Transcripts for TPRG1 Gene

mRNA/cDNA for TPRG1 Gene

5 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPRG1

Alternative Splicing Database (ASD) splice patterns (SP) for TPRG1 Gene

No ASD Table

Relevant External Links for TPRG1 Gene

GeneLoc Exon Structure for

Expression for TPRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPRG1 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.8), Vagina (x6.7), Skin - Sun Exposed (Lower leg) (x5.9), Skin - Not Sun Exposed (Suprapubic) (x5.4), and Cervix - Ectocervix (x4.7).

Protein differential expression in normal tissues from HIPED for TPRG1 Gene

This gene is overexpressed in Cervix (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TPRG1 Gene

Protein tissue co-expression partners for TPRG1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TPRG1

SOURCE GeneReport for Unigene cluster for TPRG1 Gene:


mRNA Expression by UniProt/SwissProt for TPRG1 Gene:

Tissue specificity: Expressed in the epidermal layer of the skin.

Evidence on tissue expression from TISSUES for TPRG1 Gene

  • Nervous system(4)
  • Kidney(2.7)
genes like me logo Genes that share expression patterns with TPRG1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TPRG1 Gene

Orthologs for TPRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPRG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPRG1 31 30
  • 99.52 (n)
(Canis familiaris)
Mammalia TPRG1 31 30
  • 90.18 (n)
(Bos Taurus)
Mammalia TPRG1 31 30
  • 87.52 (n)
(Rattus norvegicus)
Mammalia Tprg1 30
  • 84.91 (n)
(Mus musculus)
Mammalia Tprg 17 31 30
  • 84.73 (n)
(Ornithorhynchus anatinus)
Mammalia TPRG1 31
  • 76 (a)
(Monodelphis domestica)
Mammalia TPRG1 31
  • 73 (a)
(Anolis carolinensis)
Reptilia TPRG1 31
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tprg1 30
  • 60.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68514 30
(Danio rerio)
Actinopterygii tprg1 31 30
  • 57.05 (n)
Species where no ortholog for TPRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPRG1 Gene

Gene Tree for TPRG1 (if available)
Gene Tree for TPRG1 (if available)
Evolutionary constrained regions (ECRs) for TPRG1: view image

Paralogs for TPRG1 Gene

Paralogs for TPRG1 Gene

(1) SIMAP similar genes for TPRG1 Gene using alignment to 4 proteins:

  • H7C1G4_HUMAN Pseudogenes for TPRG1 Gene

genes like me logo Genes that share paralogs with TPRG1: view

Variants for TPRG1 Gene

Additional dbSNP identifiers (rs#s) for TPRG1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TPRG1 Gene

Variant ID Type Subtype PubMed ID
esv2726358 CNV deletion 23290073
nsv236710 CNV deletion 16902084
nsv829819 CNV gain 17160897

Variation tolerance for TPRG1 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TPRG1 Gene

Disorders for TPRG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TPRG1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemangioma of spleen
  • splenic hemangioma
mixed liposarcoma
  • myxoid/round cell liposarcoma
- elite association - COSMIC cancer census association via MalaCards
Search TPRG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TPRG1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TPRG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPRG1 Gene

Publications for TPRG1 Gene

  1. Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study. (PMID: 19475631) Evangelou E … Genetic Epidemiology of Parkinson's Disease (GEOPD) Consortium (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PMID: 24144296) Cheng CY … Baird PN (American journal of human genetics 2013) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for TPRG1 Gene

Sources for TPRG1 Gene