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Aliases for TPRA1 Gene

Aliases for TPRA1 Gene

  • Transmembrane Protein Adipocyte Associated 1 2 3 5
  • Transmembrane Protein 227 2 3 4
  • Transmembrane Protein, Adipocyte Asscociated 1 2 3
  • Integral Membrane Protein GPR175 3 4
  • G Protein-Coupled Receptor 175 2 3
  • TMEM227 3 4
  • GPR175 3 4
  • Transmembrane Domain Protein Regulated In Adipocytes 40 KDa 3
  • Transmembrane Protein Adipocyte-Associated 1 3
  • Seven Transmembrane Domain Orphan Receptor 3
  • TPRA40 3

External Ids for TPRA1 Gene

Previous HGNC Symbols for TPRA1 Gene

  • GPR175

Previous GeneCards Identifiers for TPRA1 Gene

  • GC03M128776
  • GC03M127291
  • GC03M124672

Summaries for TPRA1 Gene

GeneCards Summary for TPRA1 Gene

TPRA1 (Transmembrane Protein Adipocyte Associated 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity.

Additional gene information for TPRA1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPRA1 Gene

Genomics for TPRA1 Gene

GeneHancer (GH) Regulatory Elements for TPRA1 Gene

Promoters and enhancers for TPRA1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I127597 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 577.1 -0.3 -304 2.7 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B TPRA1 MCM2 PODXL2
GH03I127588 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 569.3 +7.2 7223 4.7 HDGF PKNOX1 CLOCK ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 TPRA1 PIR40762 PODXL2 ABTB1 MIR7976
GH03I127888 Enhancer 1.4 FANTOM5 Ensembl ENCODE 24.5 -291.6 -291635 3.2 PKNOX1 FEZF1 IRF4 ZNF280A E2F8 ZNF143 FOS ATF7 RUNX3 SP3 TPRA1 KBTBD12 PODXL2 GC03P127885 GC03P127895
GH03I128481 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13 -889.5 -889498 11.8 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 POLR2B ZNF143 FOS GATA2-AS1 GATA2 RPL32P3 ISY1 TPRA1 DNAJB8 DNAJB8-AS1 H1FX H1FX-AS1 IFT122
GH03I127671 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 12.5 -74.6 -74630 2.8 ATF1 FOXA2 ARID4B SIN3A POLR2B GLIS2 ZNF213 ATF7 SP3 SMARCB1 ABTB1 GC03P127674 GC03P127673 TPRA1 PODXL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPRA1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TPRA1 Gene

Genomic Locations for TPRA1 Gene
25,188 bases
Minus strand

Genomic View for TPRA1 Gene

Genes around TPRA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRA1 Gene

Proteins for TPRA1 Gene

  • Protein details for TPRA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein adipocyte-associated 1
    Protein Accession:
    Secondary Accessions:
    • A8MVB8
    • D3DNA9
    • Q8WZ24
    • Q96AJ6
    • Q9P2R4

    Protein attributes for TPRA1 Gene

    373 amino acids
    Molecular mass:
    41053 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPRA1 Gene


neXtProt entry for TPRA1 Gene

Post-translational modifications for TPRA1 Gene

  • Ubiquitination at posLast=289289
  • Glycosylation at isoforms=2, 311, posLast=2323, and posLast=361361
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TPRA1 Gene

Domains & Families for TPRA1 Gene

Gene Families for TPRA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TPRA1 Gene


Suggested Antigen Peptide Sequences for TPRA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0359 family.
  • Belongs to the UPF0359 family.
genes like me logo Genes that share domains with TPRA1: view

Function for TPRA1 Gene

Phenotypes From GWAS Catalog for TPRA1 Gene

Gene Ontology (GO) - Molecular Function for TPRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10342878
genes like me logo Genes that share ontologies with TPRA1: view
genes like me logo Genes that share phenotypes with TPRA1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TPRA1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPRA1 Gene

Localization for TPRA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRA1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPRA1 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TPRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPRA1: view

Pathways & Interactions for TPRA1 Gene

SuperPathways for TPRA1 Gene

No Data Available

Interacting Proteins for TPRA1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000347748 Q86W33-TPRA1_HUMAN for TPRA1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TPRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 10342878
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007568 aging TAS 10342878
GO:0040016 embryonic cleavage IEA --
GO:1901991 negative regulation of mitotic cell cycle phase transition IEA --
genes like me logo Genes that share ontologies with TPRA1: view

No data available for Pathways by source and SIGNOR curated interactions for TPRA1 Gene

Drugs & Compounds for TPRA1 Gene

No Compound Related Data Available

Transcripts for TPRA1 Gene

Unigene Clusters for TPRA1 Gene

Transmembrane protein, adipocyte asscociated 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPRA1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7: -

Relevant External Links for TPRA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPRA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPRA1 Gene

Protein differential expression in normal tissues from HIPED for TPRA1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TPRA1 Gene

Protein tissue co-expression partners for TPRA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TPRA1 Gene:


SOURCE GeneReport for Unigene cluster for TPRA1 Gene:


mRNA Expression by UniProt/SwissProt for TPRA1 Gene:

Tissue specificity: Ubiquitous, with higher levels in heart, placenta and kidney.

Evidence on tissue expression from TISSUES for TPRA1 Gene

  • Nervous system(4.4)
  • Pancreas(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with TPRA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPRA1 Gene

Orthologs for TPRA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPRA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPRA1 33 34
  • 99.91 (n)
(Canis familiaris)
Mammalia TPRA1 33 34
  • 91.39 (n)
(Bos Taurus)
Mammalia TPRA1 33 34
  • 88.4 (n)
(Mus musculus)
Mammalia Tpra1 33 16 34
  • 86.99 (n)
(Rattus norvegicus)
Mammalia Tpra1 33
  • 86.63 (n)
(Ornithorhynchus anatinus)
Mammalia TPRA1 34
  • 85 (a)
(Monodelphis domestica)
Mammalia TPRA1 34
  • 78 (a)
(Gallus gallus)
Aves TPRA1 33 34
  • 77.78 (n)
(Anolis carolinensis)
Reptilia TPRA1 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpra1 33
  • 74.02 (n)
Str.17655 33
(Danio rerio)
Actinopterygii tpra1 33 34
  • 72.05 (n)
wufc75f12 33
(Caenorhabditis elegans)
Secernentea tpra-1 33 34
  • 44.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
Species where no ortholog for TPRA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPRA1 Gene

Gene Tree for TPRA1 (if available)
Gene Tree for TPRA1 (if available)

Paralogs for TPRA1 Gene

No data available for Paralogs for TPRA1 Gene

Variants for TPRA1 Gene

Sequence variations from dbSNP and Humsavar for TPRA1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs375851208 pathogenic, Deafness, autosomal dominant 70 127,599,441(-) C/T upstream_transcript_variant
rs1000019089 -- 127,573,484(-) T/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1000198840 -- 127,579,055(-) G/A intron_variant
rs1000239595 -- 127,585,869(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000345902 -- 127,586,192(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TPRA1 Gene

Variant ID Type Subtype PubMed ID
dgv8563n54 CNV loss 21841781

Variation tolerance for TPRA1 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPRA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPRA1 Gene

Disorders for TPRA1 Gene

Additional Disease Information for TPRA1

No disorders were found for TPRA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPRA1 Gene

Publications for TPRA1 Gene

  1. Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice. (PMID: 10342878) Yang H … Montrose-Rafizadeh C (Endocrinology 1999) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism. (PMID: 25464930) Shen C … Zhong N (Journal of molecular neuroscience : MN 2015) 3 58
  5. The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels. (PMID: 26451044) Singh J … Scales SJ (The Journal of biological chemistry 2015) 3 58

Products for TPRA1 Gene

Sources for TPRA1 Gene

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