Aliases for TPRA1 Gene

Aliases for TPRA1 Gene

  • Transmembrane Protein Adipocyte Associated 1 2 3 5
  • Transmembrane Protein 227 2 3 4
  • Transmembrane Protein, Adipocyte Asscociated 1 2 3
  • Transmembrane Protein Adipocyte-Associated 1 3 4
  • Integral Membrane Protein GPR175 3 4
  • G Protein-Coupled Receptor 175 2 3
  • TMEM227 3 4
  • GPR175 3 4
  • Transmembrane Domain Protein Regulated In Adipocytes 40 KDa 3
  • Seven Transmembrane Domain Orphan Receptor 3
  • TPRA40 3

External Ids for TPRA1 Gene

Previous HGNC Symbols for TPRA1 Gene

  • GPR175

Previous GeneCards Identifiers for TPRA1 Gene

  • GC03M128776
  • GC03M127291
  • GC03M124672

Summaries for TPRA1 Gene

GeneCards Summary for TPRA1 Gene

TPRA1 (Transmembrane Protein Adipocyte Associated 1) is a Protein Coding gene. Diseases associated with TPRA1 include Fox-Fordyce Disease and Hyperhidrosis, Gustatory. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity.

Additional gene information for TPRA1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TPRA1 Gene

Genomics for TPRA1 Gene

GeneHancer (GH) Regulatory Elements for TPRA1 Gene

Promoters and enhancers for TPRA1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J127588 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 519.3 +7.5 7468 5.2 EP300 ZBTB40 ZNF217 CTCF TCF12 SIN3A MYC POLR2G SP1 PHF8 TPRA1 piR-47763 MCM2 ABTB1 PODXL2 MIR7976
GH03J127597 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -0.7 -734 3.6 FOXK2 EP300 SIN3A MYC NRF1 POLR2G USF1 SP1 PHF8 ZFX MCM2 TPRA1 ENSG00000285600
GH03J128481 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 15.9 -889.3 -889258 12.2 HNRNPK CTCF NRF1 POLR2G GTF2E2 PHF8 FOS ZFX ZIC2 ZBTB10 GATA2-AS1 GATA2 TPRA1 ISY1 DNAJB8 RPL32P3 ENSG00000244932 H1-10 DNAJB8-AS1 MBD4
GH03J127888 Enhancer 1.3 FANTOM5 Ensembl ENCODE 24.5 -291.6 -291619 3.2 ZBTB40 CTCF USF1 RBAK ZNF639 ZIC2 ZNF423 AFF1 TOE1 TRIM22 TPRA1 KBTBD12 PODXL2 lnc-KBTBD12-2 lnc-MGLL-3 lnc-RUVBL1-1 MGLL
GH03J128407 Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.9 -814.9 -814913 10.8 CTCF NRF1 USF1 GTF2E2 JUND ZBTB5 ZIC2 ZBTB11 AFF1 GABPA HSALNG0028794 GATA2 DNAJB8 TPRA1 ISY1 RPL32P3 ENSG00000244932 H1-10 DNAJB8-AS1 EEFSEC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TPRA1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TPRA1

Genomic Locations for TPRA1 Gene

Genomic Locations for TPRA1 Gene
27,036 bases
Minus strand
25,187 bases
Minus strand

Genomic View for TPRA1 Gene

Genes around TPRA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPRA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPRA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPRA1 Gene

Proteins for TPRA1 Gene

  • Protein details for TPRA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein adipocyte-associated 1
    Protein Accession:
    Secondary Accessions:
    • A8MVB8
    • D3DNA9
    • Q8WZ24
    • Q96AJ6
    • Q9P2R4

    Protein attributes for TPRA1 Gene

    373 amino acids
    Molecular mass:
    41053 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPRA1 Gene


neXtProt entry for TPRA1 Gene

Post-translational modifications for TPRA1 Gene

  • Glycosylation at Asn11, Asn23, and Asn361
  • Ubiquitination at Lys289
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TPRA1 Gene

Domains & Families for TPRA1 Gene

Gene Families for TPRA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TPRA1 Gene


Suggested Antigen Peptide Sequences for TPRA1 Gene

GenScript: Design optimal peptide antigens:
  • Integral membrane protein GPR175 (TPRA1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0359 family.
  • Belongs to the UPF0359 family.
genes like me logo Genes that share domains with TPRA1: view

Function for TPRA1 Gene

Phenotypes From GWAS Catalog for TPRA1 Gene

Gene Ontology (GO) - Molecular Function for TPRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS 10342878
GO:0005515 protein binding IPI 25464930
genes like me logo Genes that share ontologies with TPRA1: view
genes like me logo Genes that share phenotypes with TPRA1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TPRA1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPRA1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPRA1 Gene

Localization for TPRA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPRA1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPRA1 gene
Compartment Confidence
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TPRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPRA1: view

Pathways & Interactions for TPRA1 Gene

PathCards logo

SuperPathways for TPRA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 10342878
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007568 aging TAS 10342878
GO:0040016 embryonic cleavage IEA --
GO:1901991 negative regulation of mitotic cell cycle phase transition IEA --
genes like me logo Genes that share ontologies with TPRA1: view

No data available for Pathways by source and SIGNOR curated interactions for TPRA1 Gene

Drugs & Compounds for TPRA1 Gene

No Compound Related Data Available

Transcripts for TPRA1 Gene

mRNA/cDNA for TPRA1 Gene

14 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPRA1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPRA1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7: -

Relevant External Links for TPRA1 Gene

GeneLoc Exon Structure for

Expression for TPRA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPRA1 Gene

Protein differential expression in normal tissues from HIPED for TPRA1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TPRA1 Gene

Protein tissue co-expression partners for TPRA1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TPRA1

SOURCE GeneReport for Unigene cluster for TPRA1 Gene:


mRNA Expression by UniProt/SwissProt for TPRA1 Gene:

Tissue specificity: Ubiquitous, with higher levels in heart, placenta and kidney.

Evidence on tissue expression from TISSUES for TPRA1 Gene

  • Nervous system(4.4)
  • Pancreas(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with TPRA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPRA1 Gene

Orthologs for TPRA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPRA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPRA1 31 30
  • 99.91 (n)
(Canis familiaris)
Mammalia TPRA1 31 30
  • 91.39 (n)
(Bos Taurus)
Mammalia TPRA1 31 30
  • 88.4 (n)
(Mus musculus)
Mammalia Tpra1 17 31 30
  • 86.99 (n)
(Rattus norvegicus)
Mammalia Tpra1 30
  • 86.63 (n)
(Ornithorhynchus anatinus)
Mammalia TPRA1 31
  • 85 (a)
(Monodelphis domestica)
Mammalia TPRA1 31
  • 78 (a)
(Gallus gallus)
Aves TPRA1 31 30
  • 77.78 (n)
(Anolis carolinensis)
Reptilia TPRA1 31
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpra1 30
  • 74.02 (n)
Str.17655 30
(Danio rerio)
Actinopterygii tpra1 31 30
  • 72.05 (n)
wufc75f12 30
(Caenorhabditis elegans)
Secernentea tpra-1 31 30
  • 44.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
Species where no ortholog for TPRA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPRA1 Gene

Gene Tree for TPRA1 (if available)
Gene Tree for TPRA1 (if available)
Evolutionary constrained regions (ECRs) for TPRA1: view image

Paralogs for TPRA1 Gene

No data available for Paralogs for TPRA1 Gene

Variants for TPRA1 Gene

Additional dbSNP identifiers (rs#s) for TPRA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TPRA1 Gene

Variant ID Type Subtype PubMed ID
dgv8563n54 CNV loss 21841781

Variation tolerance for TPRA1 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPRA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TPRA1 Gene

Disorders for TPRA1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TPRA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fox-fordyce disease
  • fox fordyce disease
hyperhidrosis, gustatory
  • hyprg
- elite association - COSMIC cancer census association via MalaCards
Search TPRA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TPRA1

genes like me logo Genes that share disorders with TPRA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPRA1 Gene

Publications for TPRA1 Gene

  1. Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice. (PMID: 10342878) Yang H … Montrose-Rafizadeh C (Endocrinology 1999) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54
  5. Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism. (PMID: 25464930) Shen C … Zhong N (Journal of molecular neuroscience : MN 2015) 3 54

Products for TPRA1 Gene

Sources for TPRA1 Gene