Aliases for TPPP3 Gene

Aliases for TPPP3 Gene

  • Tubulin Polymerization Promoting Protein Family Member 3 2 3 5
  • Tubulin Polymerization-Promoting Protein Family Member 3 3 4
  • TPPP/P20 3 4
  • Brain Specific Protein 3
  • P25gamma 3
  • CGI-38 3
  • P20 3

External Ids for TPPP3 Gene

Previous GeneCards Identifiers for TPPP3 Gene

  • GC16M065984
  • GC16M067423
  • GC16M053296

Summaries for TPPP3 Gene

GeneCards Summary for TPPP3 Gene

TPPP3 (Tubulin Polymerization Promoting Protein Family Member 3) is a Protein Coding gene. Diseases associated with TPPP3 include Cerebrospinal Fluid Leak and Creutzfeldt-Jakob Disease. Gene Ontology (GO) annotations related to this gene include tubulin binding. An important paralog of this gene is TPPP.

UniProtKB/Swiss-Prot Summary for TPPP3 Gene

  • Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.

Additional gene information for TPPP3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TPPP3 Gene

Genomics for TPPP3 Gene

GeneHancer (GH) Regulatory Elements for TPPP3 Gene

Promoters and enhancers for TPPP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J067413 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.3 -21.5 -21499 4.1 CTCF ZBTB6 HCFC1 ZNF362 HLF RAD21 ZNF121 HDGF POLR2A BCL6B ZDHHC1 lnc-ZDHHC1-1 TPPP3 THAP11 PRMT7 ATP6V0D1 LRRC36 E2F4 CTCF EDC4
GH16J067389 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 -1.9 -1873 12.4 ZBTB6 POLR2A NR2F6 MYC CC2D1A HLF RAD21 MAX TEAD4 NFIB TPPP3 lnc-TPPP3-1 EDC4 LRRC36 CENPT ATP6V0D1 CTCF PRMT7 NAE1 FHOD1
GH16J067832 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 5.8 -440.0 -440022 2.5 ZNF785 SIX5 MLX RBPJ POLR2A CREB1 HCFC1 MIXL1 RUNX1 MYC piR-44130 E2F4 TRADD PLEKHG4 CENPT NFATC3 EDC4 CTCF ENSG00000263276 ENSG00000262514
GH16J067345 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 11.7 +47.2 47199 2.5 CREB1 CEBPB REST JUN SOX13 EP300 RFX5 STAT3 GATA3 FOXA1 LRRC36 ATP6V0D1 RNU1-123P TPPP3 PLEKHG4 ZDHHC1 HSD11B2 LRRC29 TMEM208 ELMO3
GH16J067362 Enhancer 1 Ensembl ENCODE 11.7 +28.7 28659 4.6 MLX USF2 NR2F6 CREB1 HLF ZNF121 RERE ELF3 CEBPG TFE3 LRRC36 DUS2 TPPP3 RNU1-123P PLEKHG4 ZDHHC1 HSD11B2 DPEP2 PRMT7 RF00003-036
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TPPP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPPP3 gene promoter:
  • ARP-1
  • ATF
  • HEN1
  • MIF-1
  • Nkx2-5
  • PPAR-gamma1
  • SRY
  • ZIC2

Genomic Locations for TPPP3 Gene

Genomic Locations for TPPP3 Gene
3,729 bases
Minus strand
3,727 bases
Minus strand

Genomic View for TPPP3 Gene

Genes around TPPP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPPP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPPP3 Gene

Proteins for TPPP3 Gene

  • Protein details for TPPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin polymerization-promoting protein family member 3
    Protein Accession:
    Secondary Accessions:
    • Q49AH9
    • Q9Y326
    • Q9Y6H0

    Protein attributes for TPPP3 Gene

    176 amino acids
    Molecular mass:
    18985 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD44478.1; Type=Frameshift; Positions=52, 77, 83, 89; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TPPP3 Gene

neXtProt entry for TPPP3 Gene

Post-translational modifications for TPPP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPPP3 Gene

No data available for DME Specific Peptides for TPPP3 Gene

Domains & Families for TPPP3 Gene

Gene Families for TPPP3 Gene

Protein Domains for TPPP3 Gene


Suggested Antigen Peptide Sequences for TPPP3 Gene

GenScript: Design optimal peptide antigens:
  • TPPP/p20 (TPPP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPPP family.
  • Belongs to the TPPP family.
genes like me logo Genes that share domains with TPPP3: view

Function for TPPP3 Gene

Molecular function for TPPP3 Gene

UniProtKB/Swiss-Prot Function:
Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.

Phenotypes From GWAS Catalog for TPPP3 Gene

Gene Ontology (GO) - Molecular Function for TPPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding IDA 17105200
genes like me logo Genes that share ontologies with TPPP3: view
genes like me logo Genes that share phenotypes with TPPP3: view

Animal Model Products

CRISPR Products

miRNA for TPPP3 Gene

miRTarBase miRNAs that target TPPP3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPPP3 Gene

Localization for TPPP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPPP3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPPP3 gene
Compartment Confidence
cytoskeleton 3
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TPPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 colocalizes_with microtubule IBA 21873635
GO:0048471 colocalizes_with perinuclear region of cytoplasm IDA 17105200
GO:0097427 colocalizes_with microtubule bundle IDA 17105200
genes like me logo Genes that share ontologies with TPPP3: view

Pathways & Interactions for TPPP3 Gene

PathCards logo

SuperPathways for TPPP3 Gene

No Data Available

Interacting Proteins for TPPP3 Gene

Gene Ontology (GO) - Biological Process for TPPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IDA 17105200
GO:0032273 positive regulation of protein polymerization IBA 21873635
GO:0046785 microtubule polymerization IBA 21873635
genes like me logo Genes that share ontologies with TPPP3: view

No data available for Pathways by source and SIGNOR curated interactions for TPPP3 Gene

Drugs & Compounds for TPPP3 Gene

(3) Drugs for TPPP3 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CHM 1 Pharma Tubulin polymerization inhibitor 0

(1) ApexBio Compounds for TPPP3 Gene

Compound Action Cas Number
CHM 1 Tubulin polymerization inhibitor 154554-41-3
genes like me logo Genes that share compounds with TPPP3: view

Transcripts for TPPP3 Gene

mRNA/cDNA for TPPP3 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPPP3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for TPPP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPPP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPPP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPPP3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3) and Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for TPPP3 Gene

This gene is overexpressed in Nasal epithelium (21.6), Oral epithelium (6.8), and Spinal cord (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TPPP3 Gene

Protein tissue co-expression partners for TPPP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPPP3 Gene:


SOURCE GeneReport for Unigene cluster for TPPP3 Gene:


Evidence on tissue expression from TISSUES for TPPP3 Gene

  • Nervous system(4.9)
  • Eye(4.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with TPPP3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPPP3 Gene

Orthologs for TPPP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPPP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TPPP3 33 32
  • 92.8 (n)
(Monodelphis domestica)
Mammalia TPPP3 33
  • 91 (a)
(Canis familiaris)
Mammalia TPPP3 33 32
  • 90.91 (n)
(Rattus norvegicus)
Mammalia Tppp3 32
  • 89.96 (n)
(Mus musculus)
Mammalia Tppp3 17 33 32
  • 89.77 (n)
(Gallus gallus)
Aves TPPP3 33
  • 85 (a)
(Anolis carolinensis)
Reptilia TPPP3 33
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tppp3 32
  • 70.64 (n)
Str.17126 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.2908 32
(Danio rerio)
Actinopterygii tppp3 33
  • 71 (a)
LOC559490 32
  • 67.07 (n)
zgc77934 32
fruit fly
(Drosophila melanogaster)
Insecta CG4893 33
  • 37 (a)
(Caenorhabditis elegans)
Secernentea C32E8.3 33
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 44 (a)
Species where no ortholog for TPPP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPPP3 Gene

Gene Tree for TPPP3 (if available)
Gene Tree for TPPP3 (if available)
Evolutionary constrained regions (ECRs) for TPPP3: view image

Paralogs for TPPP3 Gene

Paralogs for TPPP3 Gene

(3) SIMAP similar genes for TPPP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TPPP3: view

Variants for TPPP3 Gene

Sequence variations from dbSNP and Humsavar for TPPP3 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000177730 -- 67,394,562(-) A/G upstream_transcript_variant
rs1000451871 -- 67,392,298(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000502765 -- 67,393,437(-) G/A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000503652 -- 67,391,914(-) C/T 5_prime_UTR_variant, intron_variant
rs1000619018 -- 67,393,612(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TPPP3 Gene

Variant ID Type Subtype PubMed ID
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv952045 CNV deletion 24416366

Variation tolerance for TPPP3 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPPP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPPP3 Gene

Disorders for TPPP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TPPP3 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
cerebrospinal fluid leak
  • csf leak
creutzfeldt-jakob disease
  • cjd
- elite association - COSMIC cancer census association via MalaCards
Search TPPP3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TPPP3

genes like me logo Genes that share disorders with TPPP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPPP3 Gene

Publications for TPPP3 Gene

  1. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PMID: 17105200) Vincze O … Ovádi J (Biochemistry 2006) 2 3 4 23 56
  2. Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation. (PMID: 19633818) Zhou W … Hu R (Molecular and cellular biochemistry 2010) 3 4 56
  3. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PMID: 15590652) Lindersson E … Jensen PH (The Journal of biological chemistry 2005) 2 3 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 3 4 56

Products for TPPP3 Gene

Sources for TPPP3 Gene