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Aliases for TPPP2 Gene

Aliases for TPPP2 Gene

  • Tubulin Polymerization Promoting Protein Family Member 2 2 3 5
  • Protein P25-Beta 3 4
  • TPPP/P18 3 4
  • C14orf8 3 4
  • Tubulin Polymerization-Promoting Protein Family Member 2 3
  • Chromosome 14 Open Reading Frame 8 2
  • P25beta 3
  • CT152 3
  • P18 3

External Ids for TPPP2 Gene

Previous HGNC Symbols for TPPP2 Gene

  • C14orf8

Previous GeneCards Identifiers for TPPP2 Gene

  • GC14P020569
  • GC14P021498
  • GC14P001619
  • GC14P021031
  • GC14P021033
  • GC14P021043
  • GC14P021049
  • GC14P021061
  • GC14P021069
  • GC14P021081

Summaries for TPPP2 Gene

GeneCards Summary for TPPP2 Gene

TPPP2 (Tubulin Polymerization Promoting Protein Family Member 2) is a Protein Coding gene. An important paralog of this gene is TPPP3.

UniProtKB/Swiss-Prot for TPPP2 Gene

  • May bind tubulin but has no microtubule bundling activity.

Additional gene information for TPPP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPPP2 Gene

Genomics for TPPP2 Gene

GeneHancer (GH) Regulatory Elements for TPPP2 Gene

Promoters and enhancers for TPPP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I021021 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 555.4 +0.9 914 6.1 ZFP64 ZNF133 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 SP3 RXRA SP5 ENSG00000258604 TPPP2 MIR6717 NDRG2 TRAV13-1 ENSG00000255472
GH14I021030 Promoter 0.6 EPDnew 550.4 +6.1 6122 0.1 CREB1 TPPP2 ENSG00000255472 ENSG00000258604 NDRG2
GH14I021068 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 +46.9 46936 5 HDGF ARID4B SIN3A DMAP1 ZBTB7B ZNF213 E2F8 ZNF143 FOS PAF1 ARHGEF40 NDRG2 TMEM253 ZNF219 RNASE7 TPPP2 ENSG00000255472 RNASE13 RNASE6 TOX4
GH14I020997 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 11.2 -25.4 -25424 2.9 KLF17 ZIC2 POLR2A SCRT2 PRDM10 ZNF600 FOS KLF8 SCRT1 SMARCC1 SLC39A2 LOC101929718 TPPP2 ENSG00000255472 RNASE13 ZNF219 TMEM253 RNASE7 METTL17
GH14I021191 Enhancer 1 Ensembl ENCODE 9.9 +168.0 167992 1.4 ZFP64 RAD21 ZNF48 ZNF335 GLIS2 ZNF213 ZNF362 SP3 SP5 ZEB2 OR5AU1 ZNF219 TMEM253 ENSG00000255472 RNASE13 TPPP2 LOC100129923 LINC00641
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPPP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPPP2 gene promoter:

Genomic Locations for TPPP2 Gene

Genomic Locations for TPPP2 Gene
chr14:21,024,109-21,036,352
(GRCh38/hg38)
Size:
12,244 bases
Orientation:
Plus strand
chr14:21,492,268-21,504,435
(GRCh37/hg19)

Genomic View for TPPP2 Gene

Genes around TPPP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPPP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPPP2 Gene

Proteins for TPPP2 Gene

  • Protein details for TPPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59282-TPPP2_HUMAN
    Recommended name:
    Tubulin polymerization-promoting protein family member 2
    Protein Accession:
    P59282
    Secondary Accessions:
    • Q2VYF3

    Protein attributes for TPPP2 Gene

    Size:
    170 amino acids
    Molecular mass:
    18503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPPP2 Gene

Post-translational modifications for TPPP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TPPP2 Gene

Domains & Families for TPPP2 Gene

Gene Families for TPPP2 Gene

Protein Domains for TPPP2 Gene

Suggested Antigen Peptide Sequences for TPPP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59282

UniProtKB/Swiss-Prot:

TPPP2_HUMAN :
  • Belongs to the TPPP family.
Family:
  • Belongs to the TPPP family.
genes like me logo Genes that share domains with TPPP2: view

Function for TPPP2 Gene

Molecular function for TPPP2 Gene

UniProtKB/Swiss-Prot Function:
May bind tubulin but has no microtubule bundling activity.

Phenotypes From GWAS Catalog for TPPP2 Gene

Gene Ontology (GO) - Molecular Function for TPPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding IDA 17105200
genes like me logo Genes that share ontologies with TPPP2: view
genes like me logo Genes that share phenotypes with TPPP2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPPP2 Gene

Localization for TPPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPPP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPPP2 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TPPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 17105200
genes like me logo Genes that share ontologies with TPPP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TPPP2 Gene

Pathways & Interactions for TPPP2 Gene

SuperPathways for TPPP2 Gene

No Data Available

Interacting Proteins for TPPP2 Gene

Gene Ontology (GO) - Biological Process for TPPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 NOT microtubule bundle formation IMP 17105200
genes like me logo Genes that share ontologies with TPPP2: view

No data available for Pathways by source and SIGNOR curated interactions for TPPP2 Gene

Drugs & Compounds for TPPP2 Gene

(1) Drugs for TPPP2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CHM 1 Pharma Tubulin polymerization inhibitor 0

(1) ApexBio Compounds for TPPP2 Gene

Compound Action Cas Number
CHM 1 Tubulin polymerization inhibitor 154554-41-3
genes like me logo Genes that share compounds with TPPP2: view

Drug Products

Transcripts for TPPP2 Gene

Unigene Clusters for TPPP2 Gene

Tubulin polymerization-promoting protein family member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPPP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: - - - -

Relevant External Links for TPPP2 Gene

GeneLoc Exon Structure for
TPPP2
ECgene alternative splicing isoforms for
TPPP2

Expression for TPPP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPPP2 Gene

mRNA differential expression in normal tissues according to GTEx for TPPP2 Gene

This gene is overexpressed in Testis (x48.5).

Protein differential expression in normal tissues from HIPED for TPPP2 Gene

This gene is overexpressed in Testis (28.5), Skin (15.1), Ovary (14.4), and Heart (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TPPP2 Gene



Protein tissue co-expression partners for TPPP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TPPP2 Gene:

TPPP2

SOURCE GeneReport for Unigene cluster for TPPP2 Gene:

Hs.406966

mRNA Expression by UniProt/SwissProt for TPPP2 Gene:

P59282-TPPP2_HUMAN
Tissue specificity: Expressed in spermatids. Detected in liver cancer (at protein level).

Evidence on tissue expression from TISSUES for TPPP2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TPPP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPPP2 Gene

Orthologs for TPPP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPPP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPPP2 33 34
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia TPPP2 33 34
  • 89.29 (n)
dog
(Canis familiaris)
Mammalia TPPP2 33 34
  • 86.31 (n)
rat
(Rattus norvegicus)
Mammalia Tppp2 33
  • 84.71 (n)
mouse
(Mus musculus)
Mammalia Tppp2 33 16 34
  • 83.14 (n)
oppossum
(Monodelphis domestica)
Mammalia TPPP2 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPPP2 33 34
  • 69.7 (n)
lizard
(Anolis carolinensis)
Reptilia TPPP2 34
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TPPP2 34
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4893 34
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C32E8.3 33 34
  • 51.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
OneToMany
Species where no ortholog for TPPP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TPPP2 Gene

ENSEMBL:
Gene Tree for TPPP2 (if available)
TreeFam:
Gene Tree for TPPP2 (if available)

Paralogs for TPPP2 Gene

Paralogs for TPPP2 Gene

(3) SIMAP similar genes for TPPP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TPPP2: view

Variants for TPPP2 Gene

Sequence variations from dbSNP and Humsavar for TPPP2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000119394 -- 21,032,810(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000975098 -- 21,022,765(+) G/A upstream_transcript_variant
rs1001034548 -- 21,030,196(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001107937 -- 21,030,029(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001457179 -- 21,024,285(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TPPP2 Gene

Variant ID Type Subtype PubMed ID
nsv1039369 CNV loss 25217958
nsv428293 CNV gain+loss 18775914
nsv832740 CNV gain 17160897

Variation tolerance for TPPP2 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPPP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPPP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPPP2 Gene

Disorders for TPPP2 Gene

Additional Disease Information for TPPP2

No disorders were found for TPPP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPPP2 Gene

Publications for TPPP2 Gene

  1. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. (PMID: 17105200) Vincze O … Ovádi J (Biochemistry 2006) 2 3 4 58
  2. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. (PMID: 15590652) Lindersson E … Jensen PH (The Journal of biological chemistry 2005) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PMID: 23436708) Liu M … Sha J (Proteomics 2013) 4 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for TPPP2 Gene

Sources for TPPP2 Gene

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