Aliases for TPP2 Gene
External Ids for TPP2 Gene
Previous GeneCards Identifiers for TPP2 Gene
This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
GeneCards Summary for TPP2 Gene
TPP2 (Tripeptidyl Peptidase 2) is a Protein Coding gene. Diseases associated with TPP2 include Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome and Evans' Syndrome. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and peptide binding. An important paralog of this gene is MBTPS1.
UniProtKB/Swiss-Prot Summary for TPP2 Gene
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity).