Aliases for TPMT Gene
External Ids for TPMT Gene
Previous GeneCards Identifiers for TPMT Gene
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
GeneCards Summary for TPMT Gene
TPMT (Thiopurine S-Methyltransferase) is a Protein Coding gene. Diseases associated with TPMT include Thiopurines, Poor Metabolism Of, 1 and Azathioprine Or 6-Mercatopurine Toxicity Or Dose Selection. Among its related pathways are Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics and Metabolism. Gene Ontology (GO) annotations related to this gene include S-adenosylmethionine-dependent methyltransferase activity and thiopurine S-methyltransferase activity.
UniProtKB/Swiss-Prot Summary for TPMT Gene
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.