Aliases for TPH1 Gene
External Ids for TPH1 Gene
Previous HGNC Symbols for TPH1 Gene
Previous GeneCards Identifiers for TPH1 Gene
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]
GeneCards Summary for TPH1 Gene
TPH1 (Tryptophan Hydroxylase 1) is a Protein Coding gene. Diseases associated with TPH1 include Anxiety and Avoidant Personality Disorder. Among its related pathways are Circadian rythm related genes and Tryptophan metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is TPH2.
Hydroxylases are enzymes that catalyze the addition of hydroxyl groups to substrates during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 22.214.171.124), steroid 11-beta hydroxylase (E.C. 126.96.36.199), and LTB4 omega-hydroxylase (E.C. 188.8.131.52).