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Aliases for TPGS2 Gene

Aliases for TPGS2 Gene

  • Tubulin Polyglutamylase Complex Subunit 2 2 3 5
  • C18orf10 3 4
  • PGS2 3 4
  • Chromosome 18 Open Reading Frame 10 2
  • HMFN0601 3
  • L17 3

External Ids for TPGS2 Gene

Previous HGNC Symbols for TPGS2 Gene

  • C18orf10

Previous GeneCards Identifiers for TPGS2 Gene

  • GC18M034377
  • GC18M034359

Summaries for TPGS2 Gene

Entrez Gene Summary for TPGS2 Gene

  • This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for TPGS2 Gene

TPGS2 (Tubulin Polyglutamylase Complex Subunit 2) is a Protein Coding gene.

Additional gene information for TPGS2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPGS2 Gene

Genomics for TPGS2 Gene

GeneHancer (GH) Regulatory Elements for TPGS2 Gene

Promoters and enhancers for TPGS2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I036827 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 564.2 +0.4 445 3.3 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 TPGS2 KIAA1328 ENSG00000267707 LOC105372071
GH18I036830 Enhancer 0.2 ENCODE 550.8 -1.4 -1416 0.1 TPGS2 KIAA1328 LOC105372069
GH18I036691 Enhancer 0.8 Ensembl ENCODE 19.1 +136.1 136110 3.3 TFAP4 FOXA2 FOXA3 BATF ZNF7 TEAD3 JUND POLR2A CEBPA GLIS1 TPGS2 LOC105372071 KIAA1328 FHOD3
GH18I036711 Enhancer 0.6 ENCODE 19.1 +117.5 117508 0.9 MAZ ZFP37 KLF17 ZNF398 JUND ZNF629 GLIS1 FOS TPGS2 LOC105372071 KIAA1328 FHOD3
GH18I036671 Enhancer 0.8 Ensembl ENCODE 13.3 +156.5 156473 1.9 PKNOX1 MAFG CEBPB FEZF1 CEBPG EP300 ZNF217 PRDM6 ZSCAN5C STAT3 TPGS2 LOC105372071 KIAA1328 FHOD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPGS2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TPGS2 Gene

Genomic Locations for TPGS2 Gene
51,747 bases
Minus strand

Genomic View for TPGS2 Gene

Genes around TPGS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPGS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPGS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPGS2 Gene

Proteins for TPGS2 Gene

  • Protein details for TPGS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin polyglutamylase complex subunit 2
    Protein Accession:
    Secondary Accessions:
    • B4DIX2
    • K7EIJ9
    • Q4KN59
    • Q8WTU3
    • Q96BT9
    • Q9Y435

    Protein attributes for TPGS2 Gene

    300 amino acids
    Molecular mass:
    33318 Da
    Quaternary structure:
    • Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.
    • Sequence=AAH22199.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43322.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TPGS2 Gene


neXtProt entry for TPGS2 Gene

Post-translational modifications for TPGS2 Gene

No data available for DME Specific Peptides for TPGS2 Gene

Domains & Families for TPGS2 Gene

Gene Families for TPGS2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TPGS2 Gene


Suggested Antigen Peptide Sequences for TPGS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TPGS2: view

No data available for UniProtKB/Swiss-Prot for TPGS2 Gene

Function for TPGS2 Gene

Phenotypes From GWAS Catalog for TPGS2 Gene

genes like me logo Genes that share phenotypes with TPGS2: view

Animal Models for TPGS2 Gene

MGI Knock Outs for TPGS2:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPGS2 Gene

Localization for TPGS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPGS2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPGS2 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TPGS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TPGS2: view

Pathways & Interactions for TPGS2 Gene

SuperPathways for TPGS2 Gene

No Data Available

Interacting Proteins for TPGS2 Gene

Gene Ontology (GO) - Biological Process for TPGS2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TPGS2 Gene

Drugs & Compounds for TPGS2 Gene

No Compound Related Data Available

Transcripts for TPGS2 Gene

Unigene Clusters for TPGS2 Gene

Tubulin polyglutamylase complex subunit 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPGS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i · 1j ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - - - -
SP12: - - - -
SP13: - -

ExUns: 10b · 10c ^ 11
SP1: - -
SP3: - -

Relevant External Links for TPGS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPGS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPGS2 Gene

Protein differential expression in normal tissues from HIPED for TPGS2 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TPGS2 Gene

Protein tissue co-expression partners for TPGS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPGS2 Gene:


SOURCE GeneReport for Unigene cluster for TPGS2 Gene:


Evidence on tissue expression from TISSUES for TPGS2 Gene

  • Nervous system(4.9)
  • Lung(4.5)
  • Liver(4.2)
  • Pancreas(4.2)
  • Eye(3.4)
genes like me logo Genes that share expression patterns with TPGS2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPGS2 Gene

Orthologs for TPGS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPGS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPGS2 33 34
  • 100 (n)
(Bos Taurus)
Mammalia TPGS2 33
  • 91.97 (n)
C24H18ORF10 34
  • 91 (a)
(Canis familiaris)
Mammalia TPGS2 33 34
  • 90.3 (n)
(Rattus norvegicus)
Mammalia Tpgs2 33
  • 88.81 (n)
(Mus musculus)
Mammalia Tpgs2 33 16 34
  • 88.44 (n)
(Ornithorhynchus anatinus)
Mammalia TPGS2 34
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
-- 34
  • 65 (a)
(Gallus gallus)
Aves C18ORF10 33
  • 73.01 (n)
TPGS2 34
  • 71 (a)
(Anolis carolinensis)
Reptilia TPGS2 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpgs2 33
  • 68.91 (n)
(Danio rerio)
Actinopterygii tpgs2 33 34
  • 61.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010475 33
  • 46.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6931 33 34
  • 46.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
Species where no ortholog for TPGS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPGS2 Gene

Gene Tree for TPGS2 (if available)
Gene Tree for TPGS2 (if available)

Paralogs for TPGS2 Gene

No data available for Paralogs for TPGS2 Gene

Variants for TPGS2 Gene

Sequence variations from dbSNP and Humsavar for TPGS2 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000096275 -- 36,827,143(-) A/C intron_variant
rs1000098913 -- 36,794,298(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000128607 -- 36,829,946(-) T/A upstream_transcript_variant
rs1000148995 -- 36,783,934(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000149540 -- 36,786,962(-) G/C 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for TPGS2 Gene

Variant ID Type Subtype PubMed ID
nsv817789 CNV gain 17921354
nsv576651 CNV loss 21841781
nsv438283 CNV loss 16468122
esv3642237 CNV gain 21293372
esv3642236 CNV loss 21293372
esv3583016 CNV loss 25503493
esv34228 CNV gain 17911159
esv2758722 CNV gain 17122850

Variation tolerance for TPGS2 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPGS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPGS2 Gene

Disorders for TPGS2 Gene

Additional Disease Information for TPGS2

No disorders were found for TPGS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPGS2 Gene

Publications for TPGS2 Gene

  1. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S … Nakagawara A (Oncogene 2004) 3 4 58
  2. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J … Carter P (Oncogene 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TPGS2 Gene

Sources for TPGS2 Gene

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