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Aliases for TPGS1 Gene

Aliases for TPGS1 Gene

  • Tubulin Polyglutamylase Complex Subunit 1 2 3 5
  • C19orf20 3 4
  • PGs1 3 4
  • Chromosome 19 Open Reading Frame 20 2
  • Gene Trap ROSA B-Geo 22 3
  • GTRGEO22 3

External Ids for TPGS1 Gene

Previous HGNC Symbols for TPGS1 Gene

  • C19orf20

Summaries for TPGS1 Gene

GeneCards Summary for TPGS1 Gene

TPGS1 (Tubulin Polyglutamylase Complex Subunit 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include microtubule binding and tubulin-glutamic acid ligase activity.

UniProtKB/Swiss-Prot for TPGS1 Gene

  • May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).

Additional gene information for TPGS1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPGS1 Gene

Genomics for TPGS1 Gene

GeneHancer (GH) Regulatory Elements for TPGS1 Gene

Promoters and enhancers for TPGS1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I000506 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 98 2.7 PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 LOC105372232 TPGS1 DAZAP1 MIER2 MADCAM1 C2CD4C
GH19I000510 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.5 +4.3 4315 3.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 CBX5 GZMM TPGS1 MADCAM1 RNF126 LOC105372232 CDC34
GH19I000516 Enhancer 1.3 Ensembl ENCODE dbSUPER 6.5 +10.7 10694 3.3 HDGF ATF1 ARNT TCF12 GATA2 ATF7 ZNF263 NCOA1 ZNF592 SNIP1 DAZAP1 TMEM259 CFD MIER2 PTBP1 BSG MED16 ENSG00000267317 RNF126 GRIN3B
GH19I000747 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.4 +244.4 244418 9.4 PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZBTB7B BRCA1 ZNF143 FOS SP5 MISP PRTN3 ELANE CFD FSTL3 PLPP2 TPGS1 GC19P000749 GC19P000763 PALM
GH19I000867 Enhancer 0.7 FANTOM5 3.7 +359.7 359706 0.4 KLF1 ZIC2 ZNF48 HIC1 FOXM1 CCNT2 ZFHX2 POLR2A PATZ1 ZNF600 CFD MED16 ODF3L2 ATP5F1D GPX4 TPGS1 CNN2 POLRMT BSG C19orf24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPGS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TPGS1 Gene

Genomic Locations for TPGS1 Gene
12,158 bases
Plus strand

Genomic View for TPGS1 Gene

Genes around TPGS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPGS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPGS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPGS1 Gene

Proteins for TPGS1 Gene

  • Protein details for TPGS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin polyglutamylase complex subunit 1
    Protein Accession:
    Secondary Accessions:
    • Q96GE2

    Protein attributes for TPGS1 Gene

    290 amino acids
    Molecular mass:
    31275 Da
    Quaternary structure:
    • Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.

    Alternative splice isoforms for TPGS1 Gene


neXtProt entry for TPGS1 Gene

Post-translational modifications for TPGS1 Gene

  • Ubiquitination at posLast=5454
  • Modification sites at PhosphoSitePlus

Other Protein References for TPGS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPGS1 Gene

Domains & Families for TPGS1 Gene

Gene Families for TPGS1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TPGS1 Gene


Suggested Antigen Peptide Sequences for TPGS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TPGS1: view

No data available for UniProtKB/Swiss-Prot for TPGS1 Gene

Function for TPGS1 Gene

Molecular function for TPGS1 Gene

UniProtKB/Swiss-Prot Function:
May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).

Gene Ontology (GO) - Molecular Function for TPGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IEA --
GO:0015631 tubulin binding IEA --
GO:0070740 tubulin-glutamic acid ligase activity IEA --
genes like me logo Genes that share ontologies with TPGS1: view
genes like me logo Genes that share phenotypes with TPGS1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPGS1 Gene

Localization for TPGS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPGS1 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, axon. Cell projection, dendrite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPGS1 gene
Compartment Confidence
cytoskeleton 5
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TPGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TPGS1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TPGS1 Gene

Pathways & Interactions for TPGS1 Gene

SuperPathways for TPGS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007288 sperm axoneme assembly IEA --
GO:0018095 protein polyglutamylation IEA --
genes like me logo Genes that share ontologies with TPGS1: view

No data available for Pathways by source and SIGNOR curated interactions for TPGS1 Gene

Drugs & Compounds for TPGS1 Gene

No Compound Related Data Available

Transcripts for TPGS1 Gene

mRNA/cDNA for TPGS1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TPGS1 Gene

Tubulin polyglutamylase complex subunit 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPGS1 Gene

No ASD Table

Relevant External Links for TPGS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPGS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPGS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPGS1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPGS1 Gene

Protein tissue co-expression partners for TPGS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPGS1 Gene:


SOURCE GeneReport for Unigene cluster for TPGS1 Gene:

genes like me logo Genes that share expression patterns with TPGS1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPGS1 Gene

Orthologs for TPGS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPGS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TPGS1 33 34
  • 88.74 (n)
(Bos Taurus)
Mammalia TPGS1 33 34
  • 87.82 (n)
(Mus musculus)
Mammalia Tpgs1 33 16 34
  • 83.79 (n)
(Rattus norvegicus)
Mammalia Tpgs1 33
  • 82.53 (n)
(Monodelphis domestica)
Mammalia TPGS1 34
  • 77 (a)
(Gallus gallus)
Aves TPGS1 33 34
  • 68.86 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpgs1 33
  • 57.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3143 33
(Danio rerio)
Actinopterygii TPGS1 (1 of 2) 34
  • 39 (a)
CR774186.2 34
  • 37 (a)
Species where no ortholog for TPGS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPGS1 Gene

Gene Tree for TPGS1 (if available)
Gene Tree for TPGS1 (if available)

Paralogs for TPGS1 Gene

No data available for Paralogs for TPGS1 Gene

Variants for TPGS1 Gene

Sequence variations from dbSNP and Humsavar for TPGS1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000152843 -- 514,582(+) A/C intron_variant
rs1000265907 -- 509,353(+) C/A intron_variant
rs1000573842 -- 506,260(+) A/C upstream_transcript_variant
rs1000762902 -- 509,165(+) G/A intron_variant
rs1000809319 -- 511,682(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TPGS1 Gene

Variant ID Type Subtype PubMed ID
dgv1013e212 CNV gain 25503493
dgv1674n106 CNV deletion 24896259
dgv6155n54 CNV loss 21841781
dgv6166n54 CNV gain 21841781
dgv6167n54 CNV gain 21841781
esv2717714 CNV deletion 23290073
esv28250 CNV gain+loss 19812545
esv33417 CNV gain+loss 17666407
esv3574264 CNV gain 25503493
nsv428360 CNV gain 18775914
nsv470101 CNV loss 18288195
nsv509712 CNV insertion 20534489
nsv516566 CNV gain 19592680
nsv577978 CNV gain 21841781
nsv578123 CNV gain 21841781
nsv578125 CNV loss 21841781
nsv578127 CNV gain 21841781
nsv953938 CNV deletion 24416366

Variation tolerance for TPGS1 Gene

Gene Damage Index Score: 4.01; 60.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPGS1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPGS1 Gene

Disorders for TPGS1 Gene

Additional Disease Information for TPGS1

No disorders were found for TPGS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPGS1 Gene

Publications for TPGS1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase. (PMID: 12972506) Regnard C … Eddé B (Journal of cell science 2003) 2 3 58
  4. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PMID: 11441184) Dehal P … Stubbs L (Science (New York, N.Y.) 2001) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TPGS1 Gene

Sources for TPGS1 Gene

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