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Aliases for TPD52L3 Gene

Aliases for TPD52L3 Gene

  • Tumor Protein D52 Like 3 2 3 5
  • Testis Development Protein NYD-SP25 3 4
  • Tumor Protein D52-Like 3 2 4
  • HD55 3 4
  • Testis Tissue Sperm-Binding Protein Li 87P 3
  • Protein Kinase NYD-SP25 3
  • Tumor Protein D55 3
  • NYDSP25 3

External Ids for TPD52L3 Gene

Summaries for TPD52L3 Gene

Entrez Gene Summary for TPD52L3 Gene

  • This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded protein may play a role in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for TPD52L3 Gene

TPD52L3 (Tumor Protein D52 Like 3) is a Protein Coding gene. An important paralog of this gene is TPD52L2.

Additional gene information for TPD52L3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPD52L3 Gene

Genomics for TPD52L3 Gene

GeneHancer (GH) Regulatory Elements for TPD52L3 Gene

Promoters and enhancers for TPD52L3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I006328 Promoter 0.7 EPDnew 550.8 -0.1 -79 0.1 L3MBTL2 GABPB1 TPD52L3 SELENOTP1
GH09I006355 Enhancer 0.7 Ensembl ENCODE 0.3 +27.6 27563 1.2 JUND ZNF687 HLF JUNB ATF7 FOS BATF ENSG00000237158 GLDC ENSG00000236924 KDM4C GC09P006363 TPD52L3
GH09I006356 Enhancer 0.6 ENCODE 0.3 +25.9 25947 0.2 CTCF ZNF654 TRIM22 MAX REST RAD21 SMC3 ZNF143 ENSG00000237158 GLDC ENSG00000236924 KDM4C GC09P006363 TPD52L3
GH09I006354 Enhancer 0.5 Ensembl 0.3 +26.2 26151 0.2 CTCF ZNF654 ZNF143 MAX SMC3 REST RAD21 ENSG00000237158 GLDC ENSG00000236924 KDM4C GC09P006363 TPD52L3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPD52L3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPD52L3 gene promoter:

Genomic Locations for TPD52L3 Gene

Genomic Locations for TPD52L3 Gene
3,552 bases
Plus strand

Genomic View for TPD52L3 Gene

Genes around TPD52L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPD52L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPD52L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPD52L3 Gene

Proteins for TPD52L3 Gene

  • Protein details for TPD52L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor protein D55
    Protein Accession:
    Secondary Accessions:
    • Q5TCR3
    • Q5TCR4
    • Q5TCR5
    • Q8N4P5
    • Q8WWF7
    • Q96M09

    Protein attributes for TPD52L3 Gene

    140 amino acids
    Molecular mass:
    15503 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPD52L3 Gene


neXtProt entry for TPD52L3 Gene

Post-translational modifications for TPD52L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPD52L3 Gene

No data available for DME Specific Peptides for TPD52L3 Gene

Domains & Families for TPD52L3 Gene

Gene Families for TPD52L3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TPD52L3 Gene


Suggested Antigen Peptide Sequences for TPD52L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPD52 family.
  • Belongs to the TPD52 family.
genes like me logo Genes that share domains with TPD52L3: view

Function for TPD52L3 Gene

Phenotypes From GWAS Catalog for TPD52L3 Gene

Gene Ontology (GO) - Molecular Function for TPD52L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TPD52L3: view
genes like me logo Genes that share phenotypes with TPD52L3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPD52L3 Gene

Localization for TPD52L3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPD52L3 gene
Compartment Confidence
cytosol 3
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TPD52L3 Gene

Pathways & Interactions for TPD52L3 Gene

SuperPathways for TPD52L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPD52L3 Gene


No data available for Pathways by source and SIGNOR curated interactions for TPD52L3 Gene

Drugs & Compounds for TPD52L3 Gene

No Compound Related Data Available

Transcripts for TPD52L3 Gene

Unigene Clusters for TPD52L3 Gene

Tumor protein D52-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L3 Gene

No ASD Table

Relevant External Links for TPD52L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPD52L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPD52L3 Gene

mRNA differential expression in normal tissues according to GTEx for TPD52L3 Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for TPD52L3 Gene

This gene is overexpressed in Pancreatic juice (58.8) and Breast (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TPD52L3 Gene

Protein tissue co-expression partners for TPD52L3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TPD52L3 Gene:


SOURCE GeneReport for Unigene cluster for TPD52L3 Gene:


mRNA Expression by UniProt/SwissProt for TPD52L3 Gene:

Tissue specificity: Specifically expressed in testis. Expressed at 5.6-fold higher levels in adult testis than in fetal testis.
genes like me logo Genes that share expression patterns with TPD52L3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPD52L3 Gene

Orthologs for TPD52L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPD52L3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPD52L3 33 34
  • 99.52 (n)
(Bos Taurus)
Mammalia TPD52L3 34 33
  • 82.35 (n)
(Rattus norvegicus)
Mammalia Tpd52l3 33
  • 79.04 (n)
(Mus musculus)
Mammalia Trpd52l3 34 16 33
  • 78.27 (n)
(Canis familiaris)
Mammalia TPD52L3 33 34
  • 75 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 31 (a)
(Gallus gallus)
Aves TPD52L2 34
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
-- 34
  • 31 (a)
(Danio rerio)
Actinopterygii tpd52l2b 34
  • 33 (a)
tpd52l2a 34
  • 27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5174 34
  • 11 (a)
(Caenorhabditis elegans)
Secernentea F13E6.1 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9626 34
  • 25 (a)
Species where no ortholog for TPD52L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TPD52L3 Gene

Gene Tree for TPD52L3 (if available)
Gene Tree for TPD52L3 (if available)

Paralogs for TPD52L3 Gene

Paralogs for TPD52L3 Gene

(4) SIMAP similar genes for TPD52L3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TPD52L3: view

Variants for TPD52L3 Gene

Sequence variations from dbSNP and Humsavar for TPD52L3 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000132401 -- 6,332,300(+) G/A downstream_transcript_variant
rs1000784367 -- 6,330,011(+) A/T 3_prime_UTR_variant, intron_variant
rs1001062293 -- 6,326,397(+) G/C upstream_transcript_variant
rs1001353391 -- 6,331,431(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1002009368 -- 6,329,019(+) CTGTCT/CT 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TPD52L3 Gene

Variant ID Type Subtype PubMed ID
dgv7386n100 CNV gain 25217958
dgv7387n100 CNV gain 25217958
nsv1029665 CNV gain 25217958
nsv613205 CNV loss 21841781

Variation tolerance for TPD52L3 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPD52L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPD52L3 Gene

Disorders for TPD52L3 Gene

Additional Disease Information for TPD52L3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TPD52L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPD52L3 Gene

Publications for TPD52L3 Gene

  1. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PMID: 16631610) Cao Q … Li J (Biochemical and biophysical research communications 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Genome-wide association study of periodontal pathogen colonization. (PMID: 22699663) Divaris K … Offenbacher S (Journal of dental research 2012) 3 58
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58

Products for TPD52L3 Gene

Sources for TPD52L3 Gene

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