Aliases for TPCN1 Gene
External Ids for TPCN1 Gene
Previous GeneCards Identifiers for TPCN1 Gene
Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]
GeneCards Summary for TPCN1 Gene
TPCN1 (Two Pore Segment Channel 1) is a Protein Coding gene. Diseases associated with TPCN1 include Thyroid Gland Follicular Carcinoma and Thyroid Gland Cancer. Among its related pathways are Calcium signaling pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include identical protein binding and voltage-gated calcium channel activity. An important paralog of this gene is CACNA1B.
UniProtKB/Swiss-Prot Summary for TPCN1 Gene
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane.