Aliases for TPCN1 Gene
External Ids for TPCN1 Gene
Previous GeneCards Identifiers for TPCN1 Gene
Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]
GeneCards Summary for TPCN1 Gene
TPCN1 (Two Pore Segment Channel 1) is a Protein Coding gene. Diseases associated with TPCN1 include Endocrine Gland Cancer and Thyroid Cancer, Nonmedullary, 1. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include identical protein binding and voltage-gated calcium channel activity. An important paralog of this gene is TPCN2.
UniProtKB/Swiss-Prot for TPCN1 Gene
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane.