Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TPBGL Gene

Subcategory (RNA class) for TPBGL Gene

lncRNA

Aliases for TPBGL Gene

  • Trophoblast Glycoprotein Like 2 3 5

External Ids for TPBGL Gene

ORGUL Members for TPBGL Gene

Previous GeneCards Identifiers for TPBGL Gene

  • GC11P074954
  • GC11P074990

Summaries for TPBGL Gene

GeneCards Summary for TPBGL Gene

TPBGL (Trophoblast Glycoprotein Like) is a Protein Coding gene, and is affiliated with the lncRNA class. An important paralog of this gene is TPBG.

Additional gene information for TPBGL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPBGL Gene

Genomics for TPBGL Gene

GeneHancer (GH) Regulatory Elements for TPBGL Gene

Promoters and enhancers for TPBGL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I075241 Promoter/Enhancer 1.4 Ensembl ENCODE 550.8 +0.7 696 1.2 SMAD1 SIN3A YY1 ZNF766 ZNF143 ATF7 RUNX3 REST ZNF592 SETDB1 TPBGL LOC105369388 ENSG00000254429
GH11I075242 Promoter 0.9 EPDnew 550.8 0.0 -18 0.1 KLF1 MAZ SP3 ZFHX2 GLIS2 GLIS1 VEZF1 PATZ1 ZBTB26 EGR2 TPBGL LOC105369388 ZDHHC20P3
GH11I075240 Enhancer 0.7 ENCODE 550.8 -0.3 -274 0.2 KLF1 USF1 ZIC2 ZNF335 ZFHX2 GLIS2 EGR1 PATZ1 VEZF1 PRDM10 TPBGL LOC105369388 ZDHHC20P3
GH11I075149 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 5.1 -89.0 -88987 4.3 TFAP4 NFIB ZNF48 TEAD3 ZFHX2 LCORL SCRT2 NR2F6 MAFK EGR2 SLCO2B1 ENSG00000255395 XRRA1 TPBGL ZDHHC20P3
GH11I075145 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -94.1 -94133 2.9 SMAD5 HLF CEBPG DPF2 ATF4 ZNF316 FOXK2 SCRT2 CEBPA HMBOX1 SLCO2B1 ENSG00000255395 NEU3 TPBGL ARRB1 SPCS2 ZDHHC20P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPBGL on UCSC Golden Path with GeneCards custom track

Genomic Locations for TPBGL Gene

Genomic Locations for TPBGL Gene
chr11:75,240,905-75,243,704
(GRCh38/hg38)
Size:
2,800 bases
Orientation:
Plus strand
chr11:74,951,950-74,954,742
(GRCh37/hg19)

Genomic View for TPBGL Gene

Genes around TPBGL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPBGL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPBGL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPBGL Gene

Proteins for TPBGL Gene

  • Protein details for TPBGL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DKB5-TPBGL_HUMAN
    Recommended name:
    Trophoblast glycoprotein-like
    Protein Accession:
    P0DKB5

    Protein attributes for TPBGL Gene

    Size:
    382 amino acids
    Molecular mass:
    40400 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPBGL Gene

Post-translational modifications for TPBGL Gene

Other Protein References for TPBGL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPBGL Gene

Domains & Families for TPBGL Gene

Gene Families for TPBGL Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TPBGL Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TPBGL: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TPBGL Gene

Function for TPBGL Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPBGL Gene

Localization for TPBGL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPBGL Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for TPBGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPBGL: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TPBGL Gene

Pathways & Interactions for TPBGL Gene

SuperPathways for TPBGL Gene

No Data Available

Interacting Proteins for TPBGL Gene

Gene Ontology (GO) - Biological Process for TPBGL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TPBGL Gene

Drugs & Compounds for TPBGL Gene

No Compound Related Data Available

Transcripts for TPBGL Gene

mRNA/cDNA for TPBGL Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TPBGL Gene

Trophoblast glycoprotein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPBGL Gene

No ASD Table

Relevant External Links for TPBGL Gene

GeneLoc Exon Structure for
TPBGL
ECgene alternative splicing isoforms for
TPBGL

Expression for TPBGL Gene

NURSA nuclear receptor signaling pathways regulating expression of TPBGL Gene:

TPBGL

SOURCE GeneReport for Unigene cluster for TPBGL Gene:

Hs.577323
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPBGL Gene

Orthologs for TPBGL Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPBGL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPBGL 33
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia TPBGL 33 34
  • 93.28 (n)
cow
(Bos Taurus)
Mammalia TPBGL 33 34
  • 90.14 (n)
rat
(Rattus norvegicus)
Mammalia Tpbgl 33
  • 86.05 (n)
mouse
(Mus musculus)
Mammalia Gm4980 33 34
  • 85.44 (n)
Tpbgl 16
oppossum
(Monodelphis domestica)
Mammalia TPBGL 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPBGL 34
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii waif2 33 34
  • 47.6 (n)
Species where no ortholog for TPBGL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPBGL Gene

ENSEMBL:
Gene Tree for TPBGL (if available)
TreeFam:
Gene Tree for TPBGL (if available)

Paralogs for TPBGL Gene

Paralogs for TPBGL Gene

(1) SIMAP similar genes for TPBGL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TPBGL: view

Variants for TPBGL Gene

Sequence variations from dbSNP and Humsavar for TPBGL Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001493714 -- 75,239,611(+) T/C upstream_transcript_variant
rs1001608285 -- 75,239,373(+) T/C upstream_transcript_variant
rs1002155109 -- 75,244,133(+) G/T downstream_transcript_variant
rs1003132026 -- 75,243,237(+) G/T 3_prime_UTR_variant
rs1003162386 -- 75,240,371(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TPBGL Gene

Variant ID Type Subtype PubMed ID
nsv832211 CNV loss 17160897
nsv1143548 CNV deletion 24896259
nsv1070052 CNV deletion 25765185
esv3626851 CNV gain 21293372
dgv1225n100 CNV gain 25217958

Variation tolerance for TPBGL Gene

Gene Damage Index Score: 2.43; 42.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPBGL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPBGL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPBGL Gene

Disorders for TPBGL Gene

Additional Disease Information for TPBGL

No disorders were found for TPBGL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPBGL Gene

Publications for TPBGL Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TPBGL Gene

Sources for TPBGL Gene

Content
Loading form....