This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele)... See more...

Aliases for TP73 Gene

Aliases for TP73 Gene

  • Tumor Protein P73 2 3 4 5
  • P53-Like Transcription Factor 3 4
  • P53-Related Protein 3 4
  • P73 3 4

External Ids for TP73 Gene

Previous GeneCards Identifiers for TP73 Gene

  • GC01P003007
  • GC01P003526
  • GC01P003142
  • GC01P003352
  • GC01P003283
  • GC01P003592
  • GC01P002864

Summaries for TP73 Gene

Entrez Gene Summary for TP73 Gene

  • This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]

GeneCards Summary for TP73 Gene

TP73 (Tumor Protein P73) is a Protein Coding gene. Diseases associated with TP73 include Small Cell Cancer Of The Lung and Oligodendroglioma. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and 14-3-3 and Regulation of BAD Activity. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and identical protein binding. An important paralog of this gene is TP63.

UniProtKB/Swiss-Prot Summary for TP73 Gene

  • Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

Gene Wiki entry for TP73 Gene

Additional gene information for TP73 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TP73 Gene

Genomics for TP73 Gene

GeneHancer (GH) Regulatory Elements for TP73 Gene

Promoters and enhancers for TP73 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J003651 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 750.6 0.0 -15 2.2 ZNF24 L3MBTL2 ZNF121 NKRF MLLT1 CBFA2T2 NCOA6 POLR2A EGR1 GMEB1 WRAP73 TP73 lnc-MEGF6-1
GH01J003690 Promoter/Enhancer 1.2 EPDnew FANTOM5 Ensembl 806.4 +38.6 38633 1.1 ZIC2 PRDM10 ZEB2 PATZ1 POLR2A KLF17 GLIS1 INSM2 TP73 TP73-AS1 WRAP73 CEP104 AB372674-001 ENSG00000235131
GH01J003697 Promoter 0.6 EPDnew 750.2 +45.5 45511 0.1 SCRT2 SCRT1 POLR2A BHLHE40 TP73 AB372674-001 ENSG00000235131
GH01J003671 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 15.8 +21.1 21079 4.4 SP1 ETV6 RELA NKRF POLR2A ZNF687 CREM IKZF1 ZIC2 TRIM22 TP73 WRAP73 C1orf174 ENSG00000227589 LOC105378609
GH01J003746 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 11.6 +94.6 94585 2.6 ZBTB40 POLR2A ELF1 SP1 NKRF ZFX ZNF687 KAT8 KLF14 GLIS2 TP73-AS1 CCDC27 piR-31462-002 piR-38429-002 piR-36100-001 piR-45349-002 MEGF6 DFFB ENSG00000235131 TP73
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TP73 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TP73 gene promoter:
  • AREB6
  • Egr-1
  • p53

Genomic Locations for TP73 Gene

Genomic Locations for TP73 Gene
chr1:3,652,516-3,736,201
(GRCh38/hg38)
Size:
83,686 bases
Orientation:
Plus strand
chr1:3,569,084-3,652,765
(GRCh37/hg19)
Size:
83,682 bases
Orientation:
Plus strand

Genomic View for TP73 Gene

Genes around TP73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP73 Gene

Proteins for TP73 Gene

  • Protein details for TP73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15350-P73_HUMAN
    Recommended name:
    Tumor protein p73
    Protein Accession:
    O15350
    Secondary Accessions:
    • B7Z7J4
    • B7Z8Z1
    • B7Z9C1
    • C9J521
    • O15351
    • Q17RN8
    • Q5TBV5
    • Q5TBV6
    • Q8NHW9
    • Q8TDY5
    • Q8TDY6
    • Q9NTK8

    Protein attributes for TP73 Gene

    Size:
    636 amino acids
    Molecular mass:
    69623 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Isoform Beta interacts with WWOX. Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY domain). Interacts with YAP1 (phosphorylated form). Interacts with HCK (via SH3 domain); this inhibits TP73 activity and degradation.
    • (Microbial infection) Interacts with Epstein-Barr virus protein EBNA6; this interaction inhibits TP73-mediated apoptotic pathway.
    Miscellaneous:
    • Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not to be frequently mutated in human cancers, in contrast to p53/TP53. Hemizygosity is observed in neuroblastoma and oligodendroglioma.
    • Activated and stabilized by interaction with RANBP9.

    Three dimensional structures from OCA and Proteopedia for TP73 Gene

    Alternative splice isoforms for TP73 Gene

neXtProt entry for TP73 Gene

Post-translational modifications for TP73 Gene

  • Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function.
  • Higher levels of phosphorylation seen in the brain from patients with Huntington disease.
  • Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TP73 Gene

Domains & Families for TP73 Gene

Gene Families for TP73 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for TP73 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52358, highly similar to Tumor protein p73 (B7Z7J4_HUMAN)
  • p53-related protein (P73_HUMAN)
  • Transcription factor DNp73 (Q8WXG0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15350

UniProtKB/Swiss-Prot:

P73_HUMAN :
  • Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL1 tyrosine kinase SH3 domain.
  • Belongs to the p53 family.
Domain:
  • Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL1 tyrosine kinase SH3 domain.
  • The PPxY motif mediates interaction with WWOX.
Family:
  • Belongs to the p53 family.
genes like me logo Genes that share domains with TP73: view

Function for TP73 Gene

Molecular function for TP73 Gene

UniProtKB/Swiss-Prot Function:
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
UniProtKB/Swiss-Prot Induction:
Not induced by DNA damage. Isoforms lacking the transactivation domain block gene induction.
GENATLAS Biochemistry:
tumor protein 73,with two alternatively spliced isoforms,alpha and beta,activating transcription of p53-responsive genes and inhibiting cell growth by inducing apoptosis,also target of ABL1 (c-ABL) in response to DNA damage in a mismatch repair-dependent apoptosis,monoallelicaly expressed (?,paternally imprinted),frequently deleted in neuroblastoma in advanced stage but unlikely to be a suppressor gene in neuroblastoma,and other tumors (see TSG1A) (not in oligodendrogliomas,in colorectal or in oesophageal carcinomas),overexpressed in bladder carcinoma

Phenotypes From GWAS Catalog for TP73 Gene

Gene Ontology (GO) - Molecular Function for TP73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 16343436
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS,IDA 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 16343436
GO:0002039 p53 binding IPI 25417702
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TP73: view
genes like me logo Genes that share phenotypes with TP73: view

Animal Models for TP73 Gene

MGI Knock Outs for TP73:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for TP73

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TP73 Gene

Localization for TP73 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP73 Gene

Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TP73 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TP73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA 19490146
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with TP73: view

Pathways & Interactions for TP73 Gene

genes like me logo Genes that share pathways with TP73: view

Pathways by source for TP73 Gene

3 Qiagen pathways for TP73 Gene
  • 14-3-3 and Regulation of BAD Activity
  • 14-3-3 Induced Intracellular Signaling
  • ATM Pathway
1 Cell Signaling Technology pathway for TP73 Gene
1 GeneTex pathway for TP73 Gene

SIGNOR curated interactions for TP73 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TP73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0001822 kidney development IEA --
GO:0006298 mismatch repair TAS 10391249
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with TP73: view

Drugs & Compounds for TP73 Gene

(20) Drugs for TP73 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target, cofactor 2741
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0

(15) Additional Compounds for TP73 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TP73: view

Transcripts for TP73 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for TP73

Alternative Splicing Database (ASD) splice patterns (SP) for TP73 Gene

No ASD Table

Relevant External Links for TP73 Gene

GeneLoc Exon Structure for
TP73
ECgene alternative splicing isoforms for
TP73

Expression for TP73 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TP73 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TP73 Gene

This gene is overexpressed in Brain - Cerebellum (x5.0) and Brain - Cerebellar Hemisphere (x4.7).

Protein differential expression in normal tissues from HIPED for TP73 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TP73 Gene



Protein tissue co-expression partners for TP73 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TP73 Gene:

TP73

SOURCE GeneReport for Unigene cluster for TP73 Gene:

Hs.192132

mRNA Expression by UniProt/SwissProt for TP73 Gene:

O15350-P73_HUMAN
Tissue specificity: Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.

Evidence on tissue expression from TISSUES for TP73 Gene

  • Skin(4.3)
  • Blood(4.2)
  • Intestine(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TP73 Gene

Germ Layers:
  • endoderm
Systems:
  • respiratory
Regions:
Thorax:
  • lung
genes like me logo Genes that share expression patterns with TP73: view

Orthologs for TP73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TP73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP73 33
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TP73 33
  • 89 (a)
OneToOne
LOC515105 32
  • 88.47 (n)
dog
(Canis familiaris)
Mammalia TP73 32
  • 88.63 (n)
P73 33
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trp73 17 33 32
  • 85.78 (n)
rat
(Rattus norvegicus)
Mammalia Tp73 32
  • 85.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TP73 33
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TP73 33
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves TP73 33 32
  • 80.28 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TP73 33
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tp73 32
  • 72.34 (n)
zebrafish
(Danio rerio)
Actinopterygii tp73 33 32 32
  • 71.13 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11581 32
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 30 (a)
ManyToMany
CSA.2527 33
  • 27 (a)
ManyToMany
Species where no ortholog for TP73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TP73 Gene

ENSEMBL:
Gene Tree for TP73 (if available)
TreeFam:
Gene Tree for TP73 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TP73: view image

Paralogs for TP73 Gene

Paralogs for TP73 Gene

(2) SIMAP similar genes for TP73 Gene using alignment to 2 proteins:

  • P73_HUMAN
  • Q8WXG0_HUMAN
genes like me logo Genes that share paralogs with TP73: view

Variants for TP73 Gene

Sequence variations from dbSNP and Humsavar for TP73 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000018595 -- 3,708,217(+) G/A/C intron_variant
rs1000056189 -- 3,673,042(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000067675 -- 3,655,963(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000105494 -- 3,703,801(+) C/A intron_variant
rs1000118289 -- 3,736,068(+) G/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TP73 Gene

Variant ID Type Subtype PubMed ID
dgv13n100 CNV gain 25217958
dgv21n106 CNV deletion 24896259
dgv27e59 CNV duplication 20981092
dgv8e212 CNV loss 25503493
esv1032022 CNV insertion 17803354
esv1115862 CNV insertion 17803354
esv1394802 CNV insertion 17803354
esv1634361 CNV deletion 17803354
esv2758916 CNV gain 17122850
esv3378361 CNV duplication 20981092
esv3585042 CNV gain 21293372
esv3585045 CNV gain 21293372
esv994567 CNV deletion 20482838
nsv1001715 CNV loss 25217958
nsv1012423 CNV gain 25217958
nsv1075045 CNV deletion 25765185
nsv1075979 CNV deletion 25765185
nsv1140740 CNV deletion 24896259
nsv1145949 CNV insertion 26484159
nsv1150687 CNV deletion 26484159
nsv410 CNV insertion 18451855
nsv460061 CNV loss 19166990
nsv470687 CNV loss 18288195
nsv545128 CNV loss 21841781
nsv545129 CNV loss 21841781
nsv830314 CNV gain+loss 17160897
nsv951959 CNV deletion 24416366

Variation tolerance for TP73 Gene

Residual Variation Intolerance Score: 4.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TP73 Gene

Human Gene Mutation Database (HGMD)
TP73
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TP73

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP73 Gene

Disorders for TP73 Gene

MalaCards: The human disease database

(16) MalaCards diseases for TP73 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
small cell cancer of the lung
  • sclc1
oligodendroglioma
  • oligodendroglial neoplasm
ulcerative stomatitis
  • aphthous stomatitis
plexiform neurofibroma
  • neurofibroma plexiform
neurofibrosarcoma
  • neurosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search TP73 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TP73

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TP73: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TP73 Gene

Publications for TP73 Gene

  1. Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation. (PMID: 19490146) Sang M … Ozaki T (Genes to cells : devoted to molecular & cellular mechanisms 2009) 3 4 23 56
  2. Regulation of p73 by Hck through kinase-dependent and independent mechanisms. (PMID: 17535448) Paliwal P … Swarup G (BMC molecular biology 2007) 3 4 23 56
  3. Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells. (PMID: 15558019) Kramer S … Nakagawara A (Oncogene 2005) 3 4 23 56
  4. Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. (PMID: 15070730) Aqeilan RI … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 23 56
  5. A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. (PMID: 12890487) Miyazaki K … Nakagawara A (Biochemical and biophysical research communications 2003) 3 4 23 56

Products for TP73 Gene

  • Addgene plasmids for TP73

Sources for TP73 Gene