Aliases for TP73 Gene
External Ids for TP73 Gene
Previous GeneCards Identifiers for TP73 Gene
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
GeneCards Summary for TP73 Gene
TP73 (Tumor Protein P73) is a Protein Coding gene. Diseases associated with TP73 include Small Cell Cancer Of The Lung and Oligodendroglioma. Among its related pathways are ATM Pathway and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and identical protein binding. An important paralog of this gene is TP63.
UniProtKB/Swiss-Prot Summary for TP73 Gene
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.