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Aliases for TP53TG5 Gene

Aliases for TP53TG5 Gene

  • TP53 Target 5 2 3 5
  • TP53-Inducible Gene 5 Protein 3 4
  • C20orf10 3 4
  • Chromosome 20 Open Reading Frame 10 2
  • TP53-Target Gene 5 Protein 3
  • CLG01 3

External Ids for TP53TG5 Gene

Previous HGNC Symbols for TP53TG5 Gene

  • C20orf10

Previous GeneCards Identifiers for TP53TG5 Gene

  • GC20M043436
  • GC20M044002
  • GC20M040744

Summaries for TP53TG5 Gene

GeneCards Summary for TP53TG5 Gene

TP53TG5 (TP53 Target 5) is a Protein Coding gene. Among its related pathways are P38 MAPK Signaling Pathway (sino).

UniProtKB/Swiss-Prot for TP53TG5 Gene

  • May play a significant role in p53/TP53-mediating signaling pathway.

Additional gene information for TP53TG5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TP53TG5 Gene

Genomics for TP53TG5 Gene

GeneHancer (GH) Regulatory Elements for TP53TG5 Gene

Promoters and enhancers for TP53TG5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I045405 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 445 3.6 MLX ARID4B ZNF2 ZBTB7B ZNF48 GLIS2 KLF7 SP3 MXD4 REST DBNDD2 TP53TG5 SYS1 SYS1-DBNDD2
GH20I045378 Promoter 0.6 EPDnew 561.9 +29.5 29544 0.1 CREB1 TP53TG5 PIGT DBNDD2 NDUFB4P10 SYS1-DBNDD2
GH20I045415 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 21.1 -8.4 -8365 1.9 PKNOX1 CLOCK FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 PIGT DBNDD2 TP53TG5 SYS1 RPS2P7 MIR6812
GH20I045362 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.9 +44.4 44436 1.9 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SYS1 SYS1-DBNDD2 NCOA5 ZNF335 TP53TG5 PCIF1 ZSWIM1 CD40 ENSG00000271984 NDUFB4P10
GH20I045357 Enhancer 1.2 ENCODE dbSUPER 19.8 +48.7 48656 4.4 PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF207 ATF7 DBNDD2 TP53TG5 SYS1 PIGT SDC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TP53TG5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TP53TG5 gene promoter:

Genomic Locations for TP53TG5 Gene

Genomic Locations for TP53TG5 Gene
35,327 bases
Minus strand

Genomic View for TP53TG5 Gene

Genes around TP53TG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53TG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53TG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53TG5 Gene

Proteins for TP53TG5 Gene

  • Protein details for TP53TG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TP53-target gene 5 protein
    Protein Accession:

    Protein attributes for TP53TG5 Gene

    290 amino acids
    Molecular mass:
    34019 Da
    Quaternary structure:
    • Interacts with p53/TP53.

neXtProt entry for TP53TG5 Gene

Post-translational modifications for TP53TG5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TP53TG5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TP53TG5 Gene

Domains & Families for TP53TG5 Gene

Gene Families for TP53TG5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TP53TG5 Gene


Suggested Antigen Peptide Sequences for TP53TG5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TP53TG5: view

No data available for UniProtKB/Swiss-Prot for TP53TG5 Gene

Function for TP53TG5 Gene

Molecular function for TP53TG5 Gene

UniProtKB/Swiss-Prot Function:
May play a significant role in p53/TP53-mediating signaling pathway.
UniProtKB/Swiss-Prot Induction:
By p53/TP53, UV irradiation, by hydrogen peroxide treatment or by treatment with a DNA-damaging reagent.

Phenotypes From GWAS Catalog for TP53TG5 Gene

Gene Ontology (GO) - Molecular Function for TP53TG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TP53TG5: view

Phenotypes for TP53TG5 Gene

GenomeRNAi human phenotypes for TP53TG5:
genes like me logo Genes that share phenotypes with TP53TG5: view

miRNA for TP53TG5 Gene

miRTarBase miRNAs that target TP53TG5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TP53TG5 Gene

Localization for TP53TG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53TG5 Gene

Cytoplasm. Nucleus. Note=Cell cycle dependent intracellular localization.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TP53TG5 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TP53TG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,HDA 21630459
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TP53TG5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TP53TG5 Gene

Pathways & Interactions for TP53TG5 Gene

genes like me logo Genes that share pathways with TP53TG5: view

Pathways by source for TP53TG5 Gene

1 Sino Biological pathway for TP53TG5 Gene

Interacting Proteins for TP53TG5 Gene

Selected Interacting proteins: Q9Y2B4-T53G5_HUMAN for TP53TG5 Gene via IID

Gene Ontology (GO) - Biological Process for TP53TG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth NAS 10719363
GO:0035556 intracellular signal transduction NAS 10719363
genes like me logo Genes that share ontologies with TP53TG5: view

No data available for SIGNOR curated interactions for TP53TG5 Gene

Drugs & Compounds for TP53TG5 Gene

No Compound Related Data Available

Transcripts for TP53TG5 Gene

mRNA/cDNA for TP53TG5 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TP53TG5 Gene

TP53 target 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TP53TG5 Gene

No ASD Table

Relevant External Links for TP53TG5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TP53TG5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TP53TG5 Gene

mRNA differential expression in normal tissues according to GTEx for TP53TG5 Gene

This gene is overexpressed in Testis (x10.2), Brain - Spinal cord (cervical c-1) (x6.2), and Brain - Substantia nigra (x4.5).

Protein differential expression in normal tissues from HIPED for TP53TG5 Gene

This gene is overexpressed in Platelet (47.3) and Testis (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TP53TG5 Gene

Protein tissue co-expression partners for TP53TG5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TP53TG5 Gene:


SOURCE GeneReport for Unigene cluster for TP53TG5 Gene:


mRNA Expression by UniProt/SwissProt for TP53TG5 Gene:

Tissue specificity: Highly expressed in heart, brain and small intestine. Less abundant in skeletal muscle, spleen, prostate, ovary and colon. A smaller transcript is expressed specifically in the testis.

Evidence on tissue expression from TISSUES for TP53TG5 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TP53TG5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TP53TG5 Gene

Orthologs for TP53TG5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TP53TG5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TP53TG5 33 34
  • 99.2 (n)
(Canis familiaris)
Mammalia TP53TG5 33 34
  • 77.96 (n)
(Bos Taurus)
Mammalia TP53TG5 33 34
  • 76.47 (n)
(Mus musculus)
Mammalia Trp53tg5 33 16 34
  • 71.85 (n)
(Rattus norvegicus)
Mammalia Tp53tg5 33
  • 71.51 (n)
(Monodelphis domestica)
Mammalia TP53TG5 34
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia TP53TG5 34
  • 38 (a)
Species where no ortholog for TP53TG5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TP53TG5 Gene

Gene Tree for TP53TG5 (if available)
Gene Tree for TP53TG5 (if available)

Paralogs for TP53TG5 Gene

No data available for Paralogs for TP53TG5 Gene

Variants for TP53TG5 Gene

Sequence variations from dbSNP and Humsavar for TP53TG5 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000440573 -- 45,379,031(-) C/A upstream_transcript_variant
rs1000473221 -- 45,379,512(-) T/G upstream_transcript_variant
rs1000809785 -- 45,377,704(-) G/A intron_variant
rs1001963141 -- 45,378,619(-) C/T upstream_transcript_variant
rs1002265921 -- 45,378,176(-) T/G 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TP53TG5 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958

Variation tolerance for TP53TG5 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.65; 95.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TP53TG5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53TG5 Gene

Disorders for TP53TG5 Gene

Additional Disease Information for TP53TG5

No disorders were found for TP53TG5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TP53TG5 Gene

Publications for TP53TG5 Gene

  1. Isolation and characterization of a novel TP53-inducible gene, TP53TG5, which suppresses growth and shows cell cycle-dependent transition of expression. (PMID: 10719363) Isaka S … Nakamura Y (Genes, chromosomes & cancer 2000) 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. (PMID: 21244100) Virok DP … Fülöp L (Journal of proteome research 2011) 3 58

Products for TP53TG5 Gene

Sources for TP53TG5 Gene

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