Aliases for TP53RK Gene
External Ids for TP53RK Gene
Previous HGNC Symbols for TP53RK Gene
Previous GeneCards Identifiers for TP53RK Gene
GeneCards Summary for TP53RK Gene
TP53RK (TP53 Regulating Kinase) is a Protein Coding gene. Diseases associated with TP53RK include Galloway-Mowat Syndrome 4 and Galloway-Mowat Syndrome. Among its related pathways are Regulation of TP53 Activity and Gene Expression. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity.
UniProtKB/Swiss-Prot Summary for TP53RK Gene
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).