The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016] See more...

Aliases for TP53INP2 Gene

Aliases for TP53INP2 Gene

  • Tumor Protein P53 Inducible Nuclear Protein 2 2 3 5
  • PINH 2 3 4
  • DOR 2 3 4
  • Tumor Protein P53-Inducible Nuclear Protein 2 3 4
  • P53-Inducible Protein U 3 4
  • DJ1181N3.1 2 3
  • C20orf110 3 4
  • PIG-U 3 4
  • Chromosome 20 Open Reading Frame 110 2
  • Diabetes And Obesity-Regulated Gene 4
  • Diabetes And Obesity Regulated 2
  • Diabetes And Obesity-Regulated 3
  • DKFZp434B2411 2
  • DKFZp434O0827 2
  • TP53INP2 5
  • FLJ21759 2
  • FLJ23500 2
  • PIGU 3

External Ids for TP53INP2 Gene

Previous HGNC Symbols for TP53INP2 Gene

  • C20orf110

Previous GeneCards Identifiers for TP53INP2 Gene

  • GC20P034008
  • GC20P032755
  • GC20P033292
  • GC20P030071

Summaries for TP53INP2 Gene

Entrez Gene Summary for TP53INP2 Gene

  • The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]

GeneCards Summary for TP53INP2 Gene

TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2) is a Protein Coding gene. Diseases associated with TP53INP2 include Branchiootic Syndrome and Estrogen-Receptor Negative Breast Cancer. Among its related pathways are Autophagy - animal. An important paralog of this gene is TP53INP1.

UniProtKB/Swiss-Prot Summary for TP53INP2 Gene

  • Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.

Additional gene information for TP53INP2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TP53INP2 Gene

Genomics for TP53INP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TP53INP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J034703 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +4.5 4532 11.7 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 TFE3 TP53INP2 RBM12 MAP1LC3A RPL36P4 NCOA6 ERGIC3 CPNE1 DYNLRB1 ENSG00000272945 ZNF341-AS1
GH20J034514 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -188.1 -188100 3.5 SP1 HNRNPL GATAD2A PRDM10 ZNF629 REST TFE3 SOX13 IKZF1 NFKBIZ DYNLRB1 MAP1LC3A NCOA6 PIGU TP53INP2 ITCH ENSG00000206582
GH20J034577 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14 -124.2 -124238 7.8 PRDM10 ZNF629 CTCF ZNF7 JUND FOXA1 PRDM1 ZIC2 RXRB REST MAP1LC3A NCOA6 PIGU TP53INP2 ERGIC3 RF00017-3559
GH20J034570 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13 -133.4 -133438 2.2 RFX1 LEF1 IKZF1 JUND ZIC2 PKNOX1 HDAC1 ETV6 SOX6 FOXJ2 TP53INP2 MAP1LC3A RF00017-3559 PIGU
GH20J034620 Enhancer 0.9 ENCODE 16.5 -82.9 -82906 1.3 GATAD2A ATF7 TFE3 SOX13 NFKBIZ RCOR2 RXRB REST ZNF24 GABPA PIGU TP53INP2 ENSG00000231034 MAP1LC3A NCOA6 ITCH RF00017-3559
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TP53INP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TP53INP2

Top Transcription factor binding sites by QIAGEN in the TP53INP2 gene promoter:
  • AhR
  • Nkx2-5
  • Nkx5-1
  • p53
  • Pax-4a
  • PPAR-alpha
  • RREB-1
  • STAT3

Genomic Locations for TP53INP2 Gene

Genomic Locations for TP53INP2 Gene
chr20:34,704,339-34,713,439
(GRCh38/hg38)
Size:
9,101 bases
Orientation:
Plus strand
chr20:33,292,094-33,301,243
(GRCh37/hg19)
Size:
9,150 bases
Orientation:
Plus strand

Genomic View for TP53INP2 Gene

Genes around TP53INP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53INP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53INP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53INP2 Gene

Proteins for TP53INP2 Gene

  • Protein details for TP53INP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXH6-T53I2_HUMAN
    Recommended name:
    Tumor protein p53-inducible nuclear protein 2
    Protein Accession:
    Q8IXH6
    Secondary Accessions:
    • A8K8S8
    • E1P5P6
    • Q5JX64
    • Q8IYL5
    • Q9NU00

    Protein attributes for TP53INP2 Gene

    Size:
    220 amino acids
    Molecular mass:
    23980 Da
    Quaternary structure:
    • Interacts with VMP1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C and THRA.

neXtProt entry for TP53INP2 Gene

Post-translational modifications for TP53INP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TP53INP2 Gene

No data available for DME Specific Peptides for TP53INP2 Gene

Domains & Families for TP53INP2 Gene

Gene Families for TP53INP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TP53INP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TP53INP2 Gene

GenScript: Design optimal peptide antigens:
  • p53-inducible protein U (T53I2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IXH6

UniProtKB/Swiss-Prot:

T53I2_HUMAN :
  • The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.
Domain:
  • The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.
genes like me logo Genes that share domains with TP53INP2: view

Function for TP53INP2 Gene

Molecular function for TP53INP2 Gene

UniProtKB/Swiss-Prot Function:
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.

Phenotypes From GWAS Catalog for TP53INP2 Gene

Gene Ontology (GO) - Molecular Function for TP53INP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19056683
GO:0043130 ubiquitin binding IEA --
genes like me logo Genes that share ontologies with TP53INP2: view
genes like me logo Genes that share phenotypes with TP53INP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TP53INP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TP53INP2 Gene

Localization for TP53INP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53INP2 Gene

Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TP53INP2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TP53INP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 19056683
GO:0005737 cytoplasm IEA --
GO:0005776 autophagosome IBA,IDA 19056683
GO:0005829 cytosol IEA,IDA 22470510
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with TP53INP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TP53INP2 Gene

Pathways & Interactions for TP53INP2 Gene

PathCards logo

SuperPathways for TP53INP2 Gene

SuperPathway Contained pathways
1 Autophagy - animal
genes like me logo Genes that share pathways with TP53INP2: view

Pathways by source for TP53INP2 Gene

1 KEGG pathway for TP53INP2 Gene

SIGNOR curated interactions for TP53INP2 Gene

Activates:

Gene Ontology (GO) - Biological Process for TP53INP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IDA 19056683
GO:0001649 osteoblast differentiation IEA --
GO:0001894 tissue homeostasis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with TP53INP2: view

Drugs & Compounds for TP53INP2 Gene

No Compound Related Data Available

Transcripts for TP53INP2 Gene

mRNA/cDNA for TP53INP2 Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TP53INP2

Alternative Splicing Database (ASD) splice patterns (SP) for TP53INP2 Gene

No ASD Table

Relevant External Links for TP53INP2 Gene

GeneLoc Exon Structure for
TP53INP2

Expression for TP53INP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TP53INP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TP53INP2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x11.9) and Brain - Substantia nigra (x6.0).

Protein differential expression in normal tissues from HIPED for TP53INP2 Gene

This gene is overexpressed in Lung (31.7), Urinary Bladder (11.1), Colon (9.9), and Ovary (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TP53INP2 Gene



Protein tissue co-expression partners for TP53INP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TP53INP2

SOURCE GeneReport for Unigene cluster for TP53INP2 Gene:

Hs.516994

Evidence on tissue expression from TISSUES for TP53INP2 Gene

  • Heart(4.5)
  • Eye(4.4)
  • Liver(4.4)
  • Nervous system(4.2)
  • Muscle(3)
  • Skin(2.8)
  • Lung(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with TP53INP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TP53INP2 Gene

Orthologs for TP53INP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TP53INP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TP53INP2 30 31
  • 99.24 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TP53INP2 30 31
  • 91.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TP53INP2 30 31
  • 86.82 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tp53inp2 30
  • 84.55 (n)
Mouse
(Mus musculus)
Mammalia Trp53inp2 30 17 31
  • 83.79 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TP53INP2 31
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TP53INP2 30
  • 67.31 (n)
Lizard
(Anolis carolinensis)
Reptilia TP53INP2 31
  • 55 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tp53inp2 30
  • 56.63 (n)
Zebrafish
(Danio rerio)
Actinopterygii TP53INP2 31
  • 38 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta DOR 31
  • 14 (a)
OneToMany
Species where no ortholog for TP53INP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TP53INP2 Gene

ENSEMBL:
Gene Tree for TP53INP2 (if available)
TreeFam:
Gene Tree for TP53INP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TP53INP2: view image

Paralogs for TP53INP2 Gene

Paralogs for TP53INP2 Gene

(1) SIMAP similar genes for TP53INP2 Gene using alignment to 3 proteins:

  • T53I2_HUMAN
  • Q5JX65_HUMAN
  • Q5JX66_HUMAN
genes like me logo Genes that share paralogs with TP53INP2: view

Variants for TP53INP2 Gene

Additional dbSNP identifiers (rs#s) for TP53INP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TP53INP2 Gene

Variant ID Type Subtype PubMed ID
nsv1066181 CNV gain 25217958
nsv819225 CNV loss 19587683

Variation tolerance for TP53INP2 Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TP53INP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TP53INP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TP53INP2 Gene

Disorders for TP53INP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TP53INP2 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TP53INP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TP53INP2 Gene

Publications for TP53INP2 Gene

  1. Assignment of the tumor protein p53 induced nuclear protein 2 (TP53INP2) gene to human chromosome band 20q11.2 by in situ hybridization. (PMID: 15628030) Nowak J … Pébusque MJ (Cytogenetic and genome research 2005) 2 3 23
  2. TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters. (PMID: 27172002) Xu Y … Liu W (Autophagy 2016) 2 3
  3. DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription. (PMID: 22470510) Sancho A … Zorzano A (PloS one 2012) 3 4
  4. The TP53INP2 protein is required for autophagy in mammalian cells. (PMID: 19056683) Nowak J … Iovanna JL (Molecular biology of the cell 2009) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for TP53INP2 Gene

Sources for TP53INP2 Gene