Aliases for TP53INP2 Gene
External Ids for TP53INP2 Gene
Previous HGNC Symbols for TP53INP2 Gene
Previous GeneCards Identifiers for TP53INP2 Gene
The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]
GeneCards Summary for TP53INP2 Gene
TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2) is a Protein Coding gene. Diseases associated with TP53INP2 include Estrogen-Receptor Negative Breast Cancer and Branchiootic Syndrome. Among its related pathways are Autophagy - animal. An important paralog of this gene is TP53INP1.
UniProtKB/Swiss-Prot Summary for TP53INP2 Gene
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.