Aliases for TP53INP1 Gene
External Ids for TP53INP1 Gene
Previous GeneCards Identifiers for TP53INP1 Gene
GeneCards Summary for TP53INP1 Gene
TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1) is a Protein Coding gene. Diseases associated with TP53INP1 include Pediatric Ependymoma. Among its related pathways are Regulation of TP53 Activity and Gene Expression. Gene Ontology (GO) annotations related to this gene include antioxidant activity. An important paralog of this gene is TP53INP2.
UniProtKB/Swiss-Prot Summary for TP53INP1 Gene
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.