The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence.... See more...

Aliases for TP53I3 Gene

Aliases for TP53I3 Gene

  • Tumor Protein P53 Inducible Protein 3 2 3 5
  • PIG3 2 3 4
  • Quinone Oxidoreductase PIG3 3 4
  • P53-Induced Gene 3 Protein 3 4
  • Tumor Protein P53-Inducible Protein 3 4
  • Quinone Oxidoreductase Homolog 3
  • EC 1.-.-.- 4
  • TP53I3 5

External Ids for TP53I3 Gene

Previous GeneCards Identifiers for TP53I3 Gene

  • GC02M024392
  • GC02M024258
  • GC02M024274
  • GC02M024211
  • GC02M024153
  • GC02M024300
  • GC02M024039

Summaries for TP53I3 Gene

Entrez Gene Summary for TP53I3 Gene

  • The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for TP53I3 Gene

TP53I3 (Tumor Protein P53 Inducible Protein 3) is a Protein Coding gene. Diseases associated with TP53I3 include Lung Adenoma. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Gene Expression. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is VAT1.

UniProtKB/Swiss-Prot Summary for TP53I3 Gene

  • May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).

Gene Wiki entry for TP53I3 Gene

Additional gene information for TP53I3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TP53I3 Gene

Genomics for TP53I3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TP53I3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TP53I3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TP53I3

Top Transcription factor binding sites by QIAGEN in the TP53I3 gene promoter:
  • POU2F1
  • POU2F1a

Genomic Locations for TP53I3 Gene

Genomic Locations for TP53I3 Gene
chr2:24,077,428-24,085,861
(GRCh38/hg38)
Size:
8,434 bases
Orientation:
Minus strand
chr2:24,300,303-24,308,731
(GRCh37/hg19)
Size:
8,429 bases
Orientation:
Minus strand

Genomic View for TP53I3 Gene

Genes around TP53I3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53I3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53I3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53I3 Gene

Proteins for TP53I3 Gene

  • Protein details for TP53I3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53FA7-QORX_HUMAN
    Recommended name:
    Quinone oxidoreductase PIG3
    Protein Accession:
    Q53FA7
    Secondary Accessions:
    • D6W533
    • O14679
    • O14685
    • Q38G78
    • Q6JLE7
    • Q9BWB8

    Protein attributes for TP53I3 Gene

    Size:
    332 amino acids
    Molecular mass:
    35536 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAC39535.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 1]: Major isoform under normal light conditions.
    • [Isoform 2]: Major isoform under UV light exposure. Undergoes rapid proteolytic degradation by the proteasome.

    Three dimensional structures from OCA and Proteopedia for TP53I3 Gene

    Alternative splice isoforms for TP53I3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TP53I3 Gene

Post-translational modifications for TP53I3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TP53I3 Gene

Domains & Families for TP53I3 Gene

Gene Families for TP53I3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TP53I3 Gene

InterPro:
Blocks:
  • Quinone oxidoreductase/zeta-crystallin
  • Alcohol dehydrogenase GroES-like
ProtoNet:

Suggested Antigen Peptide Sequences for TP53I3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61719, highly similar to quinone oxidoreductase (EC 1.-.-.-) (B4DMQ7_HUMAN)
  • p53-induced gene 3 protein (QORX_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q53FA7

UniProtKB/Swiss-Prot:

QORX_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with TP53I3: view

Function for TP53I3 Gene

Molecular function for TP53I3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).
UniProtKB/Swiss-Prot Induction:
Isoform 1 and isoform 2 are both activated by p53/TP53, doxorubicin, etoposide and ionizing radiation. Isoform 2 is highly activated by UV radiation.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=215 uM for 1,2-naphthoquinone {ECO:0000269|PubMed:19349281};

Enzyme Numbers (IUBMB) for TP53I3 Gene

Phenotypes From GWAS Catalog for TP53I3 Gene

Gene Ontology (GO) - Molecular Function for TP53I3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003960 NADPH:quinone reductase activity IDA 19349281
GO:0016491 oxidoreductase activity IEA --
GO:0042803 protein homodimerization activity IPI 19349281
GO:0048038 quinone binding IDA 19349281
GO:0070402 NADPH binding IDA 19349281
genes like me logo Genes that share ontologies with TP53I3: view
genes like me logo Genes that share phenotypes with TP53I3: view

Animal Model Products

CRISPR Products

miRNA for TP53I3 Gene

miRTarBase miRNAs that target TP53I3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TP53I3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TP53I3 Gene

Localization for TP53I3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TP53I3 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TP53I3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TP53I3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TP53I3 Gene

Pathways & Interactions for TP53I3 Gene

genes like me logo Genes that share pathways with TP53I3: view

Gene Ontology (GO) - Biological Process for TP53I3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006739 NADP metabolic process IDA 19349281
GO:0042981 regulation of apoptotic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with TP53I3: view

No data available for SIGNOR curated interactions for TP53I3 Gene

Drugs & Compounds for TP53I3 Gene

(11) Drugs for TP53I3 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopropyl alcohol Approved, Investigational Pharma 0
Propyl alcohol Approved, Experimental Pharma 0
1-Butanol Experimental Pharma 0
NSC 319726 Pharma Reactivator of mutant p53 0
Pifithrin-α (PFTα) Pharma p53 inhibitor 0

(4) Additional Compounds for TP53I3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Caproic alcohol
  • Hexanol
  • N-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Amyl alcohol, normal
  • Amylalkohol
71-41-0
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl-1-propanol
  • 2-Methylpropanol
  • I-butanol
  • I-butyl alcohol
78-83-1

(7) ApexBio Compounds for TP53I3 Gene

Compound Action Cas Number
NSC 319726 Reactivator of mutant p53 71555-25-4
Pifithrin-α (PFTα) p53 inhibitor 63208-82-2
PRIMA-1 BAX inhibitor 5608-24-2
PRIMA-1MET Restore mutant p53 activity, induce BAX and PUMA 5291-32-7
RG7388 MDM2 antagonist, oral, selective 1229705-06-9
RITA (NSC 652287) Mdm2-p53 interaction and p53 ubiquitination blocking 213261-59-7
Tenovin-1 SIRT2 inhibitor, activates p53 380315-80-0
genes like me logo Genes that share compounds with TP53I3: view

Transcripts for TP53I3 Gene

mRNA/cDNA for TP53I3 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TP53I3

Alternative Splicing Database (ASD) splice patterns (SP) for TP53I3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b
SP1: - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6:

Relevant External Links for TP53I3 Gene

GeneLoc Exon Structure for
TP53I3

Expression for TP53I3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TP53I3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TP53I3 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.4) and Colon - Transverse (x4.2).

Protein differential expression in normal tissues from HIPED for TP53I3 Gene

This gene is overexpressed in Amniocyte (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TP53I3 Gene



Protein tissue co-expression partners for TP53I3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TP53I3

SOURCE GeneReport for Unigene cluster for TP53I3 Gene:

Hs.50649

Evidence on tissue expression from TISSUES for TP53I3 Gene

  • Stomach(4.3)
  • Muscle(4.3)
  • Intestine(2.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with TP53I3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TP53I3 Gene

Orthologs for TP53I3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TP53I3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TP53I3 30 31
  • 99.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TP53I3 30 31
  • 89.16 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TP53I3 30 31
  • 88.45 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TP53I3 31
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TP53I3 31
  • 72 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia BC026585 31
  • 23 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves TP53I3 30 31
  • 66.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 22 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tp53i3 30
  • 66.67 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC796473 30
  • 59.79 (n)
TP53I3 31
  • 57 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZTA1 31 33 33
  • 26 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G21580 30
  • 49.18 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0805600 30
  • 51.14 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01419 30
  • 52.44 (n)
Species where no ortholog for TP53I3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TP53I3 Gene

ENSEMBL:
Gene Tree for TP53I3 (if available)
TreeFam:
Gene Tree for TP53I3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TP53I3: view image

Paralogs for TP53I3 Gene

(3) SIMAP similar genes for TP53I3 Gene using alignment to 3 proteins:

  • QORX_HUMAN
  • B4DMQ7_HUMAN
  • H7BZH6_HUMAN
genes like me logo Genes that share paralogs with TP53I3: view

Variants for TP53I3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TP53I3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs899619458 A breast cancer sample p.Met180Lys
rs35176319 - p.Glu223Lys

Additional dbSNP identifiers (rs#s) for TP53I3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TP53I3 Gene

Variant ID Type Subtype PubMed ID
nsv2641 CNV deletion 18451855
nsv997445 CNV gain 25217958
nsv997725 CNV gain 25217958

Variation tolerance for TP53I3 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TP53I3 Gene

Human Gene Mutation Database (HGMD)
TP53I3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TP53I3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53I3 Gene

Disorders for TP53I3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TP53I3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
lung adenoma
  • adenoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TP53I3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TP53I3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TP53I3 Gene

Publications for TP53I3 Gene

  1. Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3. (PMID: 19349281) Porté S … Parés X (The Journal of biological chemistry 2009) 2 3 4 23
  2. UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation. (PMID: 15067011) Nicholls CD … Beattie TL (The Journal of biological chemistry 2004) 3 4 23
  3. A polymorphic microsatellite that mediates induction of PIG3 by p53. (PMID: 11919562) Contente A … Dobbelstein M (Nature genetics 2002) 2 3 23
  4. p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. (PMID: 10840161) Flatt PM … Pietenpol JA (Cancer letters 2000) 2 3 23
  5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41

Products for TP53I3 Gene

Sources for TP53I3 Gene