Aliases for TP53I13 Gene

Aliases for TP53I13 Gene

  • Tumor Protein P53 Inducible Protein 13 2 3 5
  • Damage-Stimulated Cytoplasmic Protein 1 3 4
  • Tumor Protein P53-Inducible Protein 13 3 4
  • DSCP1 3 4

External Ids for TP53I13 Gene

Previous GeneCards Identifiers for TP53I13 Gene

  • GC17P024920
  • GC17P027895
  • GC17P024125

Summaries for TP53I13 Gene

GeneCards Summary for TP53I13 Gene

TP53I13 (Tumor Protein P53 Inducible Protein 13) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for TP53I13 Gene

  • May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed.

Additional gene information for TP53I13 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TP53I13 Gene

Genomics for TP53I13 Gene

GeneHancer (GH) Regulatory Elements for TP53I13 Gene

Promoters and enhancers for TP53I13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TP53I13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TP53I13 gene promoter:
  • c-Ets-1
  • MRF-2
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • p53
  • POU2F1
  • POU2F1a

Genomic Locations for TP53I13 Gene

Genomic Locations for TP53I13 Gene
chr17:29,566,052-29,580,820
(GRCh38/hg38)
Size:
14,769 bases
Orientation:
Plus strand
chr17:27,893,070-27,900,175
(GRCh37/hg19)
Size:
7,106 bases
Orientation:
Plus strand

Genomic View for TP53I13 Gene

Genes around TP53I13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53I13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53I13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TP53I13 Gene

Proteins for TP53I13 Gene

  • Protein details for TP53I13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBR0-P5I13_HUMAN
    Recommended name:
    Tumor protein p53-inducible protein 13
    Protein Accession:
    Q8NBR0
    Secondary Accessions:
    • Q7L5U3

    Protein attributes for TP53I13 Gene

    Size:
    393 amino acids
    Molecular mass:
    42238 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TP53I13 Gene

Post-translational modifications for TP53I13 Gene

  • Glycosylation at Thr187, Thr190, Ser191, Ser224, and Ser226
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TP53I13 Gene

Domains & Families for TP53I13 Gene

Gene Families for TP53I13 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TP53I13 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TP53I13 Gene

GenScript: Design optimal peptide antigens:
  • Damage-stimulated cytoplasmic protein 1 (P5I13_HUMAN)
genes like me logo Genes that share domains with TP53I13: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TP53I13 Gene

Function for TP53I13 Gene

Molecular function for TP53I13 Gene

UniProtKB/Swiss-Prot Function:
May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed.
UniProtKB/Swiss-Prot Induction:
Up-regulated by genotoxic stresses of adriamycin and/or UV irradiation in a p53/TP53-dependent manner.

Phenotypes From GWAS Catalog for TP53I13 Gene

Gene Ontology (GO) - Molecular Function for TP53I13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TP53I13: view
genes like me logo Genes that share phenotypes with TP53I13: view

Animal Model Products

CRISPR Products

miRNA for TP53I13 Gene

miRTarBase miRNAs that target TP53I13

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TP53I13 Gene

Localization for TP53I13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53I13 Gene

Cell membrane; Single-pass type I membrane protein; Extracellular side. Cytoplasm. Note=Associates with unknown subcellular structures in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TP53I13 gene
Compartment Confidence
plasma membrane 3
extracellular 2
peroxisome 0
nucleus 0
endoplasmic reticulum 0
cytosol 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for TP53I13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IDA 14767535
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TP53I13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TP53I13 Gene

Pathways & Interactions for TP53I13 Gene

PathCards logo

SuperPathways for TP53I13 Gene

No Data Available

Interacting Proteins for TP53I13 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000301057 Q8NBR0-P5I13_HUMAN for TP53I13 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TP53I13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009411 response to UV IEP 14767535
GO:0014070 response to organic cyclic compound IEP 14767535
GO:0042493 response to drug IEP 14767535
GO:0045786 negative regulation of cell cycle IDA 14767535
genes like me logo Genes that share ontologies with TP53I13: view

No data available for Pathways by source and SIGNOR curated interactions for TP53I13 Gene

Drugs & Compounds for TP53I13 Gene

No Compound Related Data Available

Transcripts for TP53I13 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TP53I13 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11
SP1: - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - -
SP7: - -
SP8:

Relevant External Links for TP53I13 Gene

GeneLoc Exon Structure for
TP53I13
ECgene alternative splicing isoforms for
TP53I13

Expression for TP53I13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TP53I13 Gene

Protein differential expression in normal tissues from HIPED for TP53I13 Gene

This gene is overexpressed in Pancreatic juice (40.4) and Bone (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TP53I13 Gene



Protein tissue co-expression partners for TP53I13 Gene

NURSA nuclear receptor signaling pathways regulating expression of TP53I13 Gene:

TP53I13

SOURCE GeneReport for Unigene cluster for TP53I13 Gene:

Hs.514050

mRNA Expression by UniProt/SwissProt for TP53I13 Gene:

Q8NBR0-P5I13_HUMAN
Tissue specificity: Expressed in heart, placenta, skeletal muscle, testis, brain and lung.

Evidence on tissue expression from TISSUES for TP53I13 Gene

  • Nervous system(4.4)
  • Intestine(4.3)
  • Stomach(3.7)
genes like me logo Genes that share expression patterns with TP53I13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TP53I13 Gene

Orthologs for TP53I13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TP53I13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TP53I13 33 32
  • 96.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TP53I13 33 32
  • 82.96 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TP53I13 33 32
  • 80.72 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tp53i13 32
  • 78.51 (n)
mouse
(Mus musculus)
Mammalia Trp53i13 17 33 32
  • 78.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TP53I13 33
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TP53I13 33
  • 52 (a)
OneToOne
Species where no ortholog for TP53I13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TP53I13 Gene

ENSEMBL:
Gene Tree for TP53I13 (if available)
TreeFam:
Gene Tree for TP53I13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TP53I13: view image

Paralogs for TP53I13 Gene

(1) SIMAP similar genes for TP53I13 Gene using alignment to 8 proteins:

  • P5I13_HUMAN
  • H0Y3E9_HUMAN
  • J3KRJ1_HUMAN
  • J3KSX2_HUMAN
  • K7EJC6_HUMAN
  • K7EKX3_HUMAN
  • K7ELD4_HUMAN
  • K7ERH9_HUMAN
genes like me logo Genes that share paralogs with TP53I13: view

No data available for Paralogs for TP53I13 Gene

Variants for TP53I13 Gene

Sequence variations from dbSNP and Humsavar for TP53I13 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000200591 -- 29,569,356(+) G/A 5_prime_UTR_variant, coding_sequence_variant, synonymous_variant
rs1000271962 -- 29,570,791(+) C/G/T intron_variant
rs1000322357 -- 29,570,938(+) TTT/TT intron_variant
rs1000885200 -- 29,565,266(+) ATA/A upstream_transcript_variant
rs1001595270 -- 29,565,508(+) T/C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TP53I13 Gene

Variant ID Type Subtype PubMed ID
esv22811 CNV loss 19812545
nsv521557 CNV loss 19592680
nsv833409 CNV gain 17160897

Variation tolerance for TP53I13 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TP53I13 Gene

Human Gene Mutation Database (HGMD)
TP53I13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TP53I13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53I13 Gene

Disorders for TP53I13 Gene

Additional Disease Information for TP53I13

No disorders were found for TP53I13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TP53I13 Gene

Publications for TP53I13 Gene

  1. DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro. (PMID: 14767535) Hata T … Furukawa T (International journal of oncology 2004) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 56

Products for TP53I13 Gene

Sources for TP53I13 Gene