TP53I11 Gene (Protein Coding)

Tumor Protein P53 Inducible Protein 11

GC11M044881
GIFtS:
36

Aliases for TP53I11 Gene

Aliases for TP53I11 Gene

  • Tumor Protein P53 Inducible Protein 11 2 3 5
  • Tumor Protein P53-Inducible Protein 11 3 4
  • P53-Induced Gene 11 Protein 3 4
  • PIG11 3 4

External Ids for TP53I11 Gene

Previous GeneCards Identifiers for TP53I11 Gene

  • GC11M045584
  • GC11M044939
  • GC11M044889
  • GC11M044878
  • GC11M044664

Summaries for TP53I11 Gene

GeneCards Summary for TP53I11 Gene

TP53I11 (Tumor Protein P53 Inducible Protein 11) is a Protein Coding gene.

Gene Wiki entry for TP53I11 Gene

Additional gene information for TP53I11 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TP53I11 Gene

Genomics for TP53I11 Gene

GeneHancer (GH) Regulatory Elements for TP53I11 Gene

Promoters and enhancers for TP53I11 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J044949 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +0.9 948 4.3 CTCF POLR2A ZNF148 GLIS2 ZIC2 ZBTB8A LEF1 ZEB2 PATZ1 GATAD2B TP53I11 lnc-SYT13-6
GH11J045056 Promoter/Enhancer 0.5 EPDnew dbSUPER 750.1 -104.8 -104766 0.1 TP53I11 HSALNG0083910 HSALNG0083911
GH11J044952 Enhancer 0.3 dbSUPER 750.6 -1.6 -1648 0.8 ZIC2 TP53I11 HSALNG0083902
GH11J045025 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -74.9 -74878 2.9 RFX1 SP1 ZNF623 NR2F2 BCOR ADNP ZMYM3 MAX SRF PRDM11 TP53I11 TSPAN18 piR-38352-078 lnc-PRDM11-2 RF00017-904 ENSG00000287984 LOC105376650
GH11J045101 Enhancer 0.9 ENCODE dbSUPER 12.2 -151.6 -151586 1.5 CTCF MYC CC2D1A ETV6 RBM39 MAX RAD21 ARID2 REST TRIM22 TP53I11 LINC02696 PRDM11 lnc-SYT13-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TP53I11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TP53I11 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • FOXJ2 (long isoform)
  • p53

Genomic Locations for TP53I11 Gene

Genomic Locations for TP53I11 Gene
chr11:44,885,903-44,951,306
(GRCh38/hg38)
Size:
65,404 bases
Orientation:
Minus strand
chr11:44,907,454-44,972,840
(GRCh37/hg19)
Size:
65,387 bases
Orientation:
Minus strand

Genomic View for TP53I11 Gene

Genes around TP53I11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TP53I11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TP53I11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TP53I11 Gene

Proteins for TP53I11 Gene

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  • Protein details for TP53I11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14683-P5I11_HUMAN
    Recommended name:
    Tumor protein p53-inducible protein 11
    Protein Accession:
    O14683
    Secondary Accessions:
    • Q3ZCS0

    Protein attributes for TP53I11 Gene

    Size:
    189 amino acids
    Molecular mass:
    21054 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC39533.1; Type=Miscellaneous discrepancy; Note=Localized in an untranslated region: wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for TP53I11 Gene

Protein Expression for TP53I11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TP53I11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TP53I11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TP53I11 Gene

Domains & Families for TP53I11 Gene

Gene Families for TP53I11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TP53I11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TP53I11 Gene

GenScript: Design optimal peptide antigens:
  • p53-induced gene 11 protein (P5I11_HUMAN)
  • cDNA FLJ38857 fis, clone MESAN2011597 (Q8N8U5_HUMAN)
genes like me logo Genes that share domains with TP53I11: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TP53I11 Gene

Function for TP53I11 Gene

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  1. Animal Model
  2. CRISPR
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Molecular function for TP53I11 Gene

UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Phenotypes From GWAS Catalog for TP53I11 Gene

genes like me logo Genes that share phenotypes with TP53I11: view

Animal Model Products

CRISPR Products

miRNA for TP53I11 Gene

miRTarBase miRNAs that target TP53I11

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TP53I11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TP53I11 Gene

Localization for TP53I11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TP53I11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TP53I11 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2
mitochondrion 1
endoplasmic reticulum 1
peroxisome 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TP53I11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TP53I11: view

Pathways & Interactions for TP53I11 Gene

PathCards logo

SuperPathways for TP53I11 Gene

No Data Available

Interacting Proteins for TP53I11 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000436152 O14683-P5I11_HUMAN for TP53I11 Gene via STRING IID

GPS-Prot Interaction Network for TP53I11

Gene Ontology (GO) - Biological Process for TP53I11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 9305847
genes like me logo Genes that share ontologies with TP53I11: view

No data available for Pathways by source and SIGNOR curated interactions for TP53I11 Gene

Drugs & Compounds for TP53I11 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TP53I11 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TP53I11 Gene

(14) REFSEQ mRNAs :
(28) Additional mRNA sequences :
(295) Selected AceView cDNA sequences:
(23) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TP53I11

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TP53I11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - -

Relevant External Links for TP53I11 Gene

GeneLoc Exon Structure for
TP53I11
ECgene alternative splicing isoforms for
TP53I11

Expression for TP53I11 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TP53I11 Gene

mRNA expression in normal human tissues for TP53I11 Gene
mRNA expression by BioGPS for TP53I11 GenemRNA expression by GTEx for TP53I11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TP53I11 Gene

This gene is overexpressed in Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for TP53I11 Gene

This gene is overexpressed in Fetal Brain (19.3), Neutrophil (8.9), and Monocytes (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TP53I11 Gene



Protein tissue co-expression partners for TP53I11 Gene

NURSA nuclear receptor signaling pathways regulating expression of TP53I11 Gene:

TP53I11

SOURCE GeneReport for Unigene cluster for TP53I11 Gene:

Hs.554791

Evidence on tissue expression from TISSUES for TP53I11 Gene

  • Nervous system(4.7)
  • Liver(4.1)
  • Eye(2.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with TP53I11: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TP53I11 Gene

Orthologs for TP53I11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TP53I11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TP53I11 33 32
  • 99.65 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia TP53I11 33 32
  • 93.09 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia TP53I11 33 32
  • 92.38 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia TP53I11 33
  • 88 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Tp53i11 32
  • 86.52 (n)
mouse
(Mus musculus)
 Mammalia Trp53i11 17 33 32
  • 85.99 (n)
oppossum
(Monodelphis domestica)
 Mammalia TP53I11 33
  • 72 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TP53I11 33 32
  • 79.43 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia TP53I11 33
  • 75 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tp53i11 32
  • 71.63 (n)
Str.17602 32
African clawed frog
(Xenopus laevis)
 Amphibia Xl.25376 32
zebrafish
(Danio rerio)
 Actinopterygii tp53i11b 33 32
  • 69.33 (n)
 OneToMany
tp53i11a 33
  • 69 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea Y9C12A.1 33
  • 22 (a)
 OneToOne
Species where no ortholog for TP53I11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TP53I11 Gene

ENSEMBL:
Gene Tree for TP53I11 (if available)
TreeFam:
Gene Tree for TP53I11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TP53I11: view image

Paralogs for TP53I11 Gene

No data available for Paralogs for TP53I11 Gene

Variants for TP53I11 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for TP53I11 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000033701 -- 44,940,903(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000052830 -- 44,946,509(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000172109 -- 44,947,457(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000268244 -- 44,947,716(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000323269 -- 44,942,137(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TP53I11 Gene

Variant ID Type Subtype PubMed ID
nsv482977 CNV gain 15286789
nsv832140 CNV loss 17160897

Variation tolerance for TP53I11 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TP53I11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TP53I11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TP53I11 Gene

Disorders for TP53I11 Gene

Additional Disease Information for TP53I11

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TP53I11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TP53I11 Gene

Publications for TP53I11 Gene

  1. A model for p53-induced apoptosis. (PMID: 9305847) Polyak K … Vogelstein B (Nature 1997) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. A P53 target gene, PIG11, contributes to chemosensitivity of cells to arsenic trioxide. (PMID: 15225615) Liang XQ … Qin JF (FEBS letters 2004) 3 23 56
  4. P53-induced gene 11 (PIG11) involved in arsenic trioxide-induced apoptosis in human gastric cancer MGC-803 cells. (PMID: 12883691) Liang XQ … Qin JF (Oncology reports 2003) 3 23 56
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56

ExternalLinks

View latest publications for TP53I11 gene in Mastermind

Products for TP53I11 Gene

  • Boster Bio Antibodies for TP53I11
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Sources for TP53I11 Gene