Aliases for TP53BP2 Gene
External Ids for TP53BP2 Gene
Previous GeneCards Identifiers for TP53BP2 Gene
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TP53BP2 Gene
TP53BP2 (Tumor Protein P53 Binding Protein 2) is a Protein Coding gene. Diseases associated with TP53BP2 include Chromosome 1Q41-Q42 Deletion Syndrome and Lung Cancer. Among its related pathways are Beta-Adrenergic Signaling and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include identical protein binding and p53 binding. An important paralog of this gene is PPP1R13B.
UniProtKB/Swiss-Prot Summary for TP53BP2 Gene
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.