Aliases for TOR1AIP1 Gene
External Ids for TOR1AIP1 Gene
Previous GeneCards Identifiers for TOR1AIP1 Gene
This gene encodes a type 2 integral membrane protein that binds A- and B-type lamins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]
GeneCards Summary for TOR1AIP1 Gene
TOR1AIP1 (Torsin 1A Interacting Protein 1) is a Protein Coding gene. Diseases associated with TOR1AIP1 include Myopathy, Autosomal Recessive, With Rigid Spine And Distal Joint Contractures and Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2W. Gene Ontology (GO) annotations related to this gene include cytoskeletal protein binding and ATPase activator activity. An important paralog of this gene is TOR1AIP2.
UniProtKB/Swiss-Prot Summary for TOR1AIP1 Gene
Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.