Aliases for TOPBP1 Gene
External Ids for TOPBP1 Gene
Previous GeneCards Identifiers for TOPBP1 Gene
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]
GeneCards Summary for TOPBP1 Gene
TOPBP1 (DNA Topoisomerase II Binding Protein 1) is a Protein Coding gene. Diseases associated with TOPBP1 include Ataxia-Telangiectasia and Fanconi Anemia, Complementation Group J. Among its related pathways are Homologous DNA Pairing and Strand Exchange and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein C-terminus binding. An important paralog of this gene is SLF1.
UniProtKB/Swiss-Prot Summary for TOPBP1 Gene
Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042).