Aliases for TOP3B Gene
Aliases for TOP3B Gene
External Ids for TOP3B Gene
- HGNC: 11993
- Entrez Gene: 8940
- Ensembl: ENSG00000100038
- OMIM: 603582
- UniProtKB: O95985
Previous GeneCards Identifiers for TOP3B Gene
- GC22M019010
- GC22M020635
- GC22M021075
- GC22M005268
- GC22M022309
Summaries for TOP3B Gene
-
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
GeneCards Summary for TOP3B Gene
TOP3B (DNA Topoisomerase III Beta) is a Protein Coding gene. Diseases associated with TOP3B include Chromosome 22Q11.2 Duplication Syndrome. Among its related pathways are Fanconi anemia pathway and Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA). Gene Ontology (GO) annotations related to this gene include DNA topoisomerase activity. An important paralog of this gene is TOP3A.
UniProtKB/Swiss-Prot for TOP3B Gene
-
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity.
Additional gene information for TOP3B Gene
- Monarch Initiative
- Search for TOP3B at DataMed
- Search for TOP3B at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOP3B Gene
Genomics for TOP3B Gene
GeneHancer (GH) Regulatory Elements for TOP3B Gene
Promoters and enhancers for TOP3B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TOP3B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TOP3B Gene
Genomic Locations for TOP3B Gene
- chr22:21,957,025-21,982,843
- (GRCh38/hg38)
- Size:
- 25,819 bases
- Orientation:
- Minus strand
- chr22:22,311,397-22,337,213
- (GRCh37/hg19)
Genomic View for TOP3B Gene
Genes around TOP3B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.22 by Ensembl
- 22q11.22 by Entrez Gene
- 22q11.22 by HGNC
TOP3B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TOP3B Gene
Proteins for TOP3B Gene
-
Protein details for TOP3B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95985-TOP3B_HUMAN
- Recommended name:
- DNA topoisomerase 3-beta-1
- Protein Accession:
- O95985
- A0M8Q3
- Q9BUP5
Protein attributes for TOP3B Gene
- Size:
- 862 amino acids
- Molecular mass:
- 96662 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA20009.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for TOP3B Gene
Post-translational modifications for TOP3B Gene
Other Protein References for TOP3B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TOP3B
- Novus Biologicals Antibodies for TOP3B
-
Abcam antibodies for TOP3B
-
Cloud-Clone Corp. Antibodies for TOP3B
- Invitrogen Antibodies for TOP3B
- GeneTex TOP3B antibody for TOP3B
-
Santa Cruz Biotechnology (SCBT) Antibodies for TOP3B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TOP3B
- Origene Custom Protein Services for TOP3B
-
Cloud-Clone Corp. Proteins for TOP3B
- antibodies-online: Search results for 4 available TOP3B Proteins ranked by validation data
- Compare Top TOP3B Proteins
-
Quality Products:
- Search GeneTex for Proteins for TOP3B
-
Abcam proteins for TOP3B
Assay Products
No data available for DME Specific Peptides for TOP3B Gene
Domains & Families for TOP3B Gene
Gene Families for TOP3B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TOP3B Gene
Suggested Antigen Peptide Sequences for TOP3B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95985- Family:
-
- Belongs to the type IA topoisomerase family.
Function for TOP3B Gene
Molecular function for TOP3B Gene
- GENATLAS Biochemistry:
- DNA topoisomerase III,highly expressed in testis,possessing negatively supercoiled DNA relaxing activity
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
- UniProtKB/Swiss-Prot Function:
- Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity.
Enzyme Numbers (IUBMB) for TOP3B Gene
Phenotypes From GWAS Catalog for TOP3B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | IDA,HDA | 22658674 |
| GO:0003916 | DNA topoisomerase activity | TAS,IEA | 9786843 |
| GO:0003917 | DNA topoisomerase type I activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for TOP3B Gene
- MGI mutant phenotypes for TOP3B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TOP3B:
Animal Models for TOP3B Gene
- MGI Knock Outs for TOP3B:
-
- Top3b tm1Jcw
Animal Model Products
-
Taconic Biosciences Mouse Models for TOP3B
- Cyagen custom Knockout/knockin (KOKI) mouse models for TOP3B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TOP3B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TOP3B gene
- Search ViGene Biosciences for TOP3B
CRISPR Products
-
OriGene CRISPR knockouts for TOP3B
- genomics-online: gRNA clones - Search results for 91 available TOP3B gene related products
- Overview of 91 available TOP3B gene related products
- Applied Biological Materials CRISPR for TOP3B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TOP3B
- GenScript: Design CRISPR guide RNA sequences for TOP3B
miRNA Products
- Search ViGene Biosciences for TOP3B
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for TOP3B
- Browse OriGene Inhibitory RNA Products For TOP3B
- genomics-online: shRNA clones - Search results for 91 available TOP3B gene related products
- Overview of 91 available TOP3B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TOP3B gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TOP3B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TOP3B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TOP3B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TOP3B
-
ViGene Biosciences adenoviral particle packaged cDNA for TOP3B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TOP3B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TOP3B gene
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TOP3B Gene
Localization for TOP3B Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 2 |
| cytosol | 2 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000793 | condensed chromosome | IEA | -- |
| GO:0005634 | nucleus | TAS | 9786843 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for TOP3B Gene
Pathways & Interactions for TOP3B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fanconi anemia pathway | ||
| 2 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | ||
Pathways by source for TOP3B Gene
2 KEGG pathways for TOP3B Gene
Interacting Proteins for TOP3B Gene
Selected Interacting proteins:
ENSP00000349705
O95985-TOP3B_HUMAN
for TOP3B Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006265 | DNA topological change | IBA,IEA | -- |
| GO:0007059 | chromosome segregation | IEA | -- |
No data available for SIGNOR curated interactions for TOP3B Gene
Drugs & Compounds for TOP3B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Irinotecan | Approved, Investigational | Pharma | Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 1181 | ||
| Topotecan | Approved, Investigational | Pharma | Topoisomerase 1 inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 357 | ||
| Camptothecin | Experimental | Pharma | Topoisomerase I inhibitor,prototypic | 744 | ||
| Beta-Lapachone | Pharma | DNA topoisomerase I inhibitor,selective | 11 | |||
| Epirubicin HCl | Pharma | Antibiotic antitumor agent | 0 |
(9) ApexBio Compounds for TOP3B Gene
| Compound | Action | Cas Number |
|---|---|---|
| Beta-Lapachone | DNA topoisomerase I inhibitor,selective | 4707-32-8 |
| Camptothecin | Topoisomerase I inhibitor,prototypic | 7689-03-4 |
| Epirubicin HCl | Antibiotic antitumor agent | 56390-09-1 |
| Idarubicin HCl | Anthracycline and daunorubicin analog,topoisomerase inhibitor | 57852-57-0 |
| Irinotecan | Topoisomerase I inhibitor | 97682-44-5 |
| Moxifloxacin HCl | Fluoroquinolone antibiotic | 186826-86-8 |
| Topotecan HCl | Topoisomerase 1 inhibitor | 119413-54-6 |
| Voreloxin | Topo II inhibitor | 175414-77-4 |
| Voreloxin Hydrochloride | Antineoplastic naphthyridine analogue | 175519-16-1 |
Transcripts for TOP3B Gene
mRNA/cDNA for TOP3B Gene
- (18) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (139) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TOP3B Gene
CRISPR Products
-
OriGene CRISPR knockouts for TOP3B
- genomics-online: gRNA clones - Search results for 91 available TOP3B gene related products
- Overview of 91 available TOP3B gene related products
- Applied Biological Materials CRISPR for TOP3B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TOP3B
- GenScript: Design CRISPR guide RNA sequences for TOP3B
miRNA Products
- Search ViGene Biosciences for TOP3B
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for TOP3B
- Browse OriGene Inhibitory RNA Products For TOP3B
- genomics-online: shRNA clones - Search results for 91 available TOP3B gene related products
- Overview of 91 available TOP3B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TOP3B gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TOP3B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TOP3B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TOP3B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: |
| ExUns: | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||
| SP14: | - | ||||||||||||||||||||||||||||||||||||
| SP15: | - | ||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||||||||||
| SP21: |
Expression for TOP3B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Skeletal Muscle (Muscoskeletal System)
-
Thymus (Hematopoietic System)
This gene is overexpressed in Lymph node (16.9) and CD8 Tcells (10.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TOP3B Gene
NURSA nuclear receptor signaling pathways regulating expression of TOP3B Gene:
TOP3BSOURCE GeneReport for Unigene cluster for TOP3B Gene:
Hs.436401mRNA Expression by UniProt/SwissProt for TOP3B Gene:
O95985-TOP3B_HUMAN
Tissue specificity:
Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas.
Evidence on tissue expression from TISSUES for TOP3B Gene
- Skin(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for TOP3B
-
OriGene qPCR primer pairs for TOP3B
- genomics-online: primer clones - Search results for 91 available TOP3B gene related products
- Overview of 91 available TOP3B gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOP3B Gene
Orthologs for TOP3B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TOP3B 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TOP3B 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TOP3B 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | TOP3B 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Top3b 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Top3b 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | TOP3B 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TOP3B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | top3b 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53016 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | top3b 34 |
|
OneToOne | |
| LOC793414 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Top3beta 33 34 |
|
||
| Top3bgr 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | Y48C3A.14 35 33 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TOP3 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT2G32000 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os09g0500600 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.5407 33 |
|
- Species where no ortholog for TOP3B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TOP3B Gene
(1) SIMAP similar genes for TOP3B Gene using alignment to 13 proteins:
Pseudogenes.org Pseudogenes for TOP3B Gene
Variants for TOP3B Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000062436 | -- | 21,976,663(-) | C/T | intron_variant | |
| rs1000094814 | -- | 21,962,096(-) | AG/ | intron_variant | |
| rs1000106361 | -- | 21,984,388(-) | G/A | upstream_transcript_variant | |
| rs1000233244 | -- | 21,959,254(-) | G/A | intron_variant | |
| rs1000239107 | -- | 21,959,776(-) | G/A | intron_variant |
Residual Variation Intolerance Score:
10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.44;
77.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TOP3B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOP3B Gene
Disorders for TOP3B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 22q11.2 duplication syndrome |
|
|
Search TOP3B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TOP3B
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TOP3B Gene
Publications for TOP3B Gene
- One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 2 3 4 58
- A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- A new human topoisomerase III that interacts with SGS1 protein. (PMID: 9927731) Ng SW … Berkowitz RS (Nucleic acids research 1999) 3 4 58
- Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction. (PMID: 28039324) Ahmad M … Wang W (Nucleic acids research 2017) 3 58
Products for TOP3B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for TOP3B
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TOP3B
- Origene Custom Protein Services for TOP3B
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TOP3B
- Browse OriGene Inhibitory RNA Products For TOP3B
- OriGene qPCR primer pairs and template standards for TOP3B
- OriGene qPCR primer pairs for TOP3B
- OriGene CRISPR knockouts for TOP3B
- OriGene ORF clones in human for TOP3B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TOP3B
- GenScript: Next-day shipping of latest version cDNA ORF clones for TOP3B in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TOP3B
- GenScript Custom Assay Services for TOP3B
- GenScript Custom overexpressing Cell Line Services for TOP3B
- GenScript: Design CRISPR guide RNA sequences for TOP3B
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TOP3B
- Browse Sino Biological cDNA Clones
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- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TOP3B
- Novus Biologicals lysates and proteins for TOP3B
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for TOP3B
- Abcam proteins for TOP3B
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Cloud-Clone Corp. Antibodies for TOP3B
- Cloud-Clone Corp. Proteins for TOP3B
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for TOP3B
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for TOP3B
- ApexBio compounds for TOP3B
- Cyagen custom Knockout/knockin (KOKI) mouse models for TOP3B
- VectorBuilder custom plasmid, inducible vectors for TOP3B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TOP3B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 54 available TOP3B Antibodies ranked by validation data
- Compare Top TOP3B Antibodies
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- antibodies-online: Search results for available TOP3B related products ranked by validation data
- antibodies-online: Search results for 4 available TOP3B Proteins ranked by validation data
- Compare Top TOP3B Proteins
- Quality Products:
- GeneTex TOP3B antibody for TOP3B
- Search GeneTex for Proteins for TOP3B
- ViGene Biosciences adenoviral particle packaged cDNA for TOP3B gene
- ViGene Biosciences lentiviral particle packaged cDNA for TOP3B gene
- ViGene Biosciences ready-to-package AAV shRNAs for TOP3B gene
- Search ViGene Biosciences for TOP3B
- Santa Cruz Biotechnology (SCBT) Antibodies for TOP3B
- Search Santa Cruz Biotechnology (SCBT) for TOP3B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TOP3B
- Horizon Cell Lines for TOP3B
- genomics-online: cdna clones - Search results for 91 available TOP3B gene related products
- Overview of 91 available TOP3B gene related products
- orf clones - Search results for 91 available TOP3B gene related products
- Overview of 91 available TOP3B gene related products
- genomics-online: gRNA clones - Search results for 91 available TOP3B gene related products
- Overview of 91 available TOP3B gene related products
- genomics-online: primer clones - Search results for 91 available TOP3B gene related products
- Overview of 91 available TOP3B gene related products
- genomics-online: shRNA clones - Search results for 91 available TOP3B gene related products
- Overview of 91 available TOP3B gene related products
Sources for TOP3B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems