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This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays ... See more...
Aliases for TOP3B Gene
Aliases for TOP3B Gene
External Ids for TOP3B Gene
- HGNC: 11993
- Entrez Gene: 8940
- Ensembl: ENSG00000100038
- OMIM: 603582
- UniProtKB: O95985
Previous GeneCards Identifiers for TOP3B Gene
- GC22M019010
- GC22M020635
- GC22M021075
- GC22M005268
- GC22M022309
Summaries for TOP3B Gene
-
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
GeneCards Summary for TOP3B Gene
TOP3B (DNA Topoisomerase III Beta) is a Protein Coding gene. Diseases associated with TOP3B include Chromosome 22Q11.2 Duplication Syndrome and Chromosome 22Q11.2 Deletion Syndrome, Distal. Among its related pathways are Resolution of D-loop Structures through Holliday Junction Intermediates and Fanconi anemia pathway. Gene Ontology (GO) annotations related to this gene include DNA topoisomerase activity. An important paralog of this gene is TOP3A.
UniProtKB/Swiss-Prot Summary for TOP3B Gene
-
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity.
Additional gene information for TOP3B Gene
- HGNC(11993)
- Entrez Gene(8940)
- Ensembl(ENSG00000100038)
- OMIM(603582)
- UniProtKB(O95985)
- Open Targets Platform(ENSG00000100038)
- Monarch Initiative
- Search for TOP3B at DataMed
- Search for TOP3B at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TOP3B Gene
Genomics for TOP3B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TOP3B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TOP3B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TOP3B
- Top Transcription factor binding sites by QIAGEN in the TOP3B gene promoter:
-
- Arnt
- c-Myc
- Evi-1
- Max1
- Olf-1
- POU2F1
- POU2F1a
- STAT5A
- USF-1
- USF1
Genomic Locations for TOP3B Gene
Genomic Locations for TOP3B Gene
- chr22:21,957,025-21,982,816
- (GRCh38/hg38)
- Size:
- 25,792 bases
- Orientation:
- Minus strand
- chr22:22,311,397-22,337,213
- (GRCh37/hg19)
- Size:
- 25,817 bases
- Orientation:
- Minus strand
Genomic View for TOP3B Gene
Genes around TOP3B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.22 by HGNC
- 22q11.22 by Entrez Gene
- 22q11.22 by Ensembl
TOP3B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TOP3B Gene
Proteins for TOP3B Gene
-
Protein details for TOP3B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95985-TOP3B_HUMAN
- Recommended name:
- DNA topoisomerase 3-beta-1
- Protein Accession:
- O95985
- A0M8Q3
- Q9BUP5
Protein attributes for TOP3B Gene
- Size:
- 862 amino acids
- Molecular mass:
- 96662 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA20009.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for TOP3B Gene
Post-translational modifications for TOP3B Gene
Other Protein References for TOP3B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ TOP3B Antibody
-
Custom Antibody ServicesOriGene Antibodies for TOP3B
- Novus Biologicals Antibodies for TOP3B
-
Abcam antibodies for TOP3B
- Invitrogen Antibodies for TOP3B (AFLGC-TOP3B)
-
Biorbyt antibodies for TOP3B
-
Santa Cruz Biotechnology (SCBT) Antibodies for TOP3B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TOP3B
- Origene Custom Protein Services for TOP3B
- antibodies-online: Show 5 available TOP3B Proteins ranked by validation data
- Compare Top TOP3B Proteins
-
Quality Products:
-
Abcam proteins for TOP3B
No data available for DME Specific Peptides for TOP3B Gene
Domains & Families for TOP3B Gene
Gene Families for TOP3B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TOP3B Gene
- InterPro:
- Blocks:
-
- DNA topoisomerase I
- Toprim sub-domain
- ProtoNet:
Suggested Antigen Peptide Sequences for TOP3B Gene
- GenScript: Design optimal peptide antigens:
-
- DNA topoisomerase (E7EWY2_HUMAN)
- DNA topoisomerase III beta-1 (TOP3B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95985- Family:
-
- Belongs to the type IA topoisomerase family.
Function for TOP3B Gene
Molecular function for TOP3B Gene
- UniProtKB/Swiss-Prot Function:
- Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.; EC=5.6.2.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10131};.
- GENATLAS Biochemistry:
- DNA topoisomerase III,highly expressed in testis,possessing negatively supercoiled DNA relaxing activity
Enzyme Numbers (IUBMB) for TOP3B Gene
Phenotypes From GWAS Catalog for TOP3B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003916 | DNA topoisomerase activity | IEA,IBA | 21873635 |
| GO:0003917 | DNA topoisomerase type I activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for TOP3B Gene
- MGI mutant phenotypes for TOP3B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TOP3B:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- Increased cell number in G2M, increased nuclei size in G2M
- Decreased shRNA abundance
- Increased viability
- Decreased HIV-1 infection
Animal Models for TOP3B Gene
- MGI Knock Outs for TOP3B:
-
- Top3b Top3b<tm1Jcw>
Animal Model Products
-
Taconic Biosciences Mouse Models for TOP3B
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TOP3B - Select products 50% OFF >
- * TOP3B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TOP3B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TOP3B
-
Santa Cruz Biotechnology (SCBT) CRISPR for TOP3B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TOP3B
- Browse OriGene Inhibitory RNA Products For TOP3B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOP3B
Clone Products
- Applied Biological Materials (abm): Clones for TOP3B - Select products 50% OFF >
- * TOP3B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TOP3B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TOP3B
Cell Line Products
-
Horizon Cell Lines for TOP3B
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TOP3B Gene
Localization for TOP3B Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| cytosol | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000793 | condensed chromosome | IEA | -- |
| GO:0005634 | nucleus | TAS,IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for TOP3B Gene
Pathways & Interactions for TOP3B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fanconi anemia pathway | ||
| 2 | Resolution of D-loop Structures through Holliday Junction Intermediates | ||
Pathways by source for TOP3B Gene
2 KEGG pathways for TOP3B Gene
Interacting Proteins for TOP3B Gene
Selected Interacting proteins:
O95985-TOP3B_HUMAN
ENSP00000381773
for TOP3B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TOP3B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006265 | DNA topological change | IEA,IBA | 21873635 |
| GO:0007059 | chromosome segregation | IEA | -- |
No data available for SIGNOR curated interactions for TOP3B Gene
Drugs & Compounds for TOP3B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Irinotecan | Approved, Investigational | Pharma | Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 1414 | ||
| Topotecan | Approved, Investigational | Pharma | Topoisomerase 1 inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 384 | ||
| Camptothecin | Experimental | Pharma | Topoisomerase I inhibitor,prototypic | 119 | ||
| Beta-Lapachone | Pharma | DNA topoisomerase I inhibitor,selective | 14 | |||
| Epirubicin HCl | Pharma | Antibiotic antitumor agent | 0 |
(9) ApexBio Compounds for TOP3B Gene
| Compound | Action | Cas Number |
|---|---|---|
| Beta-Lapachone | DNA topoisomerase I inhibitor,selective | 4707-32-8 |
| Camptothecin | Topoisomerase I inhibitor,prototypic | 7689-03-4 |
| Epirubicin HCl | Antibiotic antitumor agent | 56390-09-1 |
| Idarubicin HCl | Anthracycline and daunorubicin analog,topoisomerase inhibitor | 57852-57-0 |
| Irinotecan | Topoisomerase I inhibitor | 97682-44-5 |
| Moxifloxacin HCl | Fluoroquinolone antibiotic | 186826-86-8 |
| Topotecan HCl | Topoisomerase 1 inhibitor | 119413-54-6 |
| Voreloxin | Topo II inhibitor | 175414-77-4 |
| Voreloxin Hydrochloride | Antineoplastic naphthyridine analogue | 175519-16-1 |
Transcripts for TOP3B Gene
mRNA/cDNA for TOP3B Gene
- 9 REFSEQ mRNAs :
- 28 NCBI additional mRNA sequence :
- 17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000357179 2863 nts (view in UCSC)
- ENST00000398793 3107 nts (view in UCSC)
- ENST00000424393 824 nts (view in UCSC)
- ENST00000430142 582 nts (view in UCSC)
- ENST00000434517 736 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TOP3B - Select products 50% OFF >
- * TOP3B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TOP3B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TOP3B
-
Santa Cruz Biotechnology (SCBT) CRISPR for TOP3B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TOP3B
- Browse OriGene Inhibitory RNA Products For TOP3B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOP3B
Clone Products
- Applied Biological Materials (abm): Clones for TOP3B - Select products 50% OFF >
- * TOP3B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TOP3B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TOP3B
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: |
| ExUns: | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||
| SP14: | - | ||||||||||||||||||||||||||||||||||||
| SP15: | - | ||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||||||||||
| SP21: |
Relevant External Links for TOP3B Gene
- GeneLoc Exon Structure for
- TOP3B
Expression for TOP3B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Skeletal Muscle (Muscoskeletal System)
-
Thymus (Hematopoietic System)
This gene is overexpressed in Lymph node (16.9) and CD8 Tcells (10.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TOP3B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TOP3B
SOURCE GeneReport for Unigene cluster for TOP3B Gene:
Hs.436401mRNA Expression by UniProt/SwissProt for TOP3B Gene:
O95985-TOP3B_HUMAN
Tissue specificity:
Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas.
Evidence on tissue expression from TISSUES for TOP3B Gene
- Skin(4.2)
Primer Products
-
OriGene qPCR primer pairs for TOP3B
-
OriGene qPCR primer pairs and template standards for TOP3B
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOP3B Gene
Orthologs for TOP3B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TOP3B 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TOP3B 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TOP3B 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | TOP3B 30 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Top3b 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Top3b 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TOP3B 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TOP3B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | top3b 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53016 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | top3b 31 |
|
OneToOne | |
| LOC793414 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Top3beta 30 31 |
|
OneToOne | |
| Top3&bgr; 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | Y48C3A.14 30 31 32 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TOP3 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G32000 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os09g0500600 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5407 30 |
|
- Species where no ortholog for TOP3B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TOP3B Gene
- ENSEMBL:
- Gene Tree for TOP3B (if available)
- TreeFam:
- Gene Tree for TOP3B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TOP3B: view image
Paralogs for TOP3B Gene
(1) SIMAP similar genes for TOP3B Gene using alignment to 13 proteins:
- TOP3B_HUMAN
- C9J9X4_HUMAN
- C9JEI7_HUMAN
- C9JEQ1_HUMAN
- C9JF56_HUMAN
- C9JHR0_HUMAN
- C9JKE2_HUMAN
- C9JT00_HUMAN
- C9JTQ7_HUMAN
- E7EWY2_HUMAN
- F2Z2A5_HUMAN
- H0Y6W0_HUMAN
- H7C4B0_HUMAN
Pseudogenes.org Pseudogenes for TOP3B Gene
Variants for TOP3B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TOP3B Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 715206 | Benign: not provided | 21,958,485(-) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT | |
| 730811 | Likely Benign: not provided | 21,963,992(-) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 740127 | Likely Benign: not provided | 21,962,883(-) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 740830 | Likely Benign: not provided | 21,963,930(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 770011 | Benign: not provided | 21,957,510(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT |
Residual Variation Intolerance Score:
10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.44;
77.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TOP3B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOP3B Gene
Disorders for TOP3B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 22q11.2 duplication syndrome |
|
|
| chromosome 22q11.2 deletion syndrome, distal |
|
|
| digeorge syndrome |
|
|
Search TOP3B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TOP3B
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TOP3B Gene
Publications for TOP3B Gene
- One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 2 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4
- A new human topoisomerase III that interacts with SGS1 protein. (PMID: 9927731) Ng SW … Berkowitz RS (Nucleic acids research 1999) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
Products for TOP3B Gene
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- antibodies-online: Show 15 available TOP3B Antibodies ranked by validation data
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- Biorbyt antibodies for TOP3B
Sources for TOP3B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
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- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
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