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TOP2A Gene(Protein Coding)

DNA Topoisomerase II Alpha

GCID:
GC17M040388
GIFtS:
61
Genes Participants
UDN Logo

Aliases for TOP2A Gene

Aliases for TOP2A Gene

  • DNA Topoisomerase II Alpha 2 3 5
  • Topoisomerase (DNA) II Alpha 170kDa 2 3
  • DNA Topoisomerase II, Alpha Isozyme 3 4
  • EC 5.99.1.3 4 56
  • TOP2 3 4
  • DNA Topoisomerase (ATP-Hydrolyzing) 3
  • DNA Topoisomerase II, 170 KD 3
  • DNA Topoisomerase 2-Alpha 3
  • DNA Gyrase 3
  • TP2A 3

External Ids for TOP2A Gene

Previous HGNC Symbols for TOP2A Gene

  • TOP2

Previous GeneCards Identifiers for TOP2A Gene

  • GC17M038044
  • GC17M040720
  • GC17M038453
  • GC17M038919
  • GC17M038920
  • GC17M035798
  • GC17M038544
  • GC17M034337

Summaries for TOP2A Gene

Entrez Gene Summary for TOP2A Gene

  • This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

CIViC summary for TOP2A Gene

GeneCards Summary for TOP2A Gene

TOP2A (DNA Topoisomerase II Alpha) is a Protein Coding gene. Diseases associated with TOP2A include Female Breast Cancer and Malignant Peripheral Nerve Sheath Tumor. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is TOP2B.

UniProtKB/Swiss-Prot for TOP2A Gene

  • Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).

Tocris Summary for TOP2A Gene

  • Topoisomerases are ubiquitously expressed enzymes that overcome topological problems in genomic DNA, which can result from DNA replication, transcription and repair. Common problems such as knots and tangles are often resolved by topoisomerases.

Gene Wiki entry for TOP2A Gene

Additional gene information for TOP2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOP2A Gene

Genomics for TOP2A Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for TOP2A Gene

Promoters and enhancers for TOP2A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17I040415 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.7 734 4 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 TOP2A GC17M040417 MED1 CDK12 RARA SMARCE1 SNORD124 MSL1 RPL23AP75 IGFBP4
GH17I040419 Enhancer 1.1 Ensembl ENCODE 550.8 -1.8 -1831 1.2 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 SLC30A9 SP5 NFYC MXD4 TOP2A GC17M040417 RPL23AP75 IGFBP4 RARA GC17M040441
GH17I040306 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 +100.4 100425 22.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RARA MED1 SMARCE1 SNORD124 CDK12 MED24 MSL1 TMEM99 CDC6 WIPF2
GH17I040442 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 -26.3 -26302 3.9 HDGF ZFP64 ARID4B SIN3A YY1 ZNF143 REST ZNF592 KAT8 SREBF1 IGFBP4 MED1 SMARCE1 CDK12 SNORD124 TOP2A CCR7 ENSG00000264968 RARA ENSG00000266208
GH17I040546 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -139.2 -139153 20.3 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 NFYC MEF2D CCR7 PIR43413 SNORD124 SMARCE1 TOP2A IGFBP4 ENSG00000266088 KRTAP3-2 KRT34 GJD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TOP2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TOP2A gene promoter:

Genomic Locations for TOP2A Gene

Genomic Locations for TOP2A Gene
chr17:40,388,516-40,417,950
(GRCh38/hg38)
Size:
29,435 bases
Orientation:
Minus strand
chr17:38,544,768-38,574,202
(GRCh37/hg19)

Genomic View for TOP2A Gene

Genes around TOP2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOP2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOP2A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TOP2A Gene

Proteins for TOP2A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TOP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11388-TOP2A_HUMAN
    Recommended name:
    DNA topoisomerase 2-alpha
    Protein Accession:
    P11388
    Secondary Accessions:
    • B2RTS1
    • Q71UN1
    • Q71UQ5
    • Q9HB24
    • Q9HB25
    • Q9HB26
    • Q9UP44
    • Q9UQP9

    Protein attributes for TOP2A Gene

    Size:
    1531 amino acids
    Molecular mass:
    174385 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer. Interacts with COPS5. Interacts with RECQL5; this stimulates DNA decatenation. Interacts with SETMAR; stimulates the topoisomerase activity (PubMed:18790802, PubMed:20457750). Interacts with DHX9; this interaction occurs in a E2 enzyme UBE2I- and RNA-dependent manner, negatively regulates DHX9-mediated double-stranded DNA and RNA duplex helicase activity and stimulates TOP2A-mediated supercoiled DNA relaxation activity (PubMed:12711669). Interacts with HNRNPU (via C-terminus); this interaction protects the topoisomerase TOP2A from degradation and positively regulates the relaxation of supercoiled DNA in a RNA-dependent manner (By similarity).
    Miscellaneous:
    • Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.

    Three dimensional structures from OCA and Proteopedia for TOP2A Gene

    Alternative splice isoforms for TOP2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOP2A Gene

Protein Expression for TOP2A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for TOP2A Gene

P11388:
  • LTKEKKDEL
  • FDSQTKE
  • DDRKEWL
  • PDLSKFKM
  • GLHKVFKLQT
  • INFIHHNWP
  • EEKLAEAE
  • VLIQRGY
  • FLYDDNQRVEPEWY
  • FLEEFITPI
  • TSSNYDD
  • RRAYDIAGSTKDVKVFLNG
  • GPEDDAAI
  • VTQQMWV
  • KVTGGRNGYGAKLCNIFST
  • KPGQRKVL
  • RPDTYIGSVE
  • DNERSIP
  • EMKAEAEK
  • LTCNSMVLFDH
  • PIIPMVL
  • KKKNKGG
  • AFYSLPEFEEWKS
  • ESILNWVKFKAQ
  • KTLRYGK
  • LLTSSNY
  • QARFILEK
  • VNAADNK
  • SDPVKAWKE
  • GLPEDYLYG
  • VVKKKNK
  • KDKLDETG
  • LDKDIVALM
  • FMEDRRQR
  • MIMTDQD
  • QLNKKCS
  • DGSHIKGL
  • GMLGAES
  • EYHTDTTV
  • NIFSTKF
  • CTLILTEG
  • KEYFADM
  • EFITPIVK
  • RWEVCLT
  • ENAEINN
  • KYYKGLGTS
  • NNGKGIP
  • GVFPLRGK
  • YKEQVLEPMLNGTEKTP
  • ASPRYIF
  • KGGRHVD
  • NGAEGIGTG
  • NLLQPIGQFGTRLHGGKD
  • LARLLFP
  • NQARFIL
  • VFLNGNKL
  • QLEHILLRPD
  • VGSNNLNLL
  • KRNPWSD
  • QVKNHMWIF
  • MWVYDEDVG
  • SFVNSIAT

Post-translational modifications for TOP2A Gene

  • Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.
  • Ubiquitination at isoforms=2, 3, 4123, posLast=207207, posLast=227227, isoforms=2, 3, 4233, isoforms=2, 3, 4251, isoforms=2, 3, 4287, posLast=321321, isoforms=2, 3, 4336, posLast=386386, isoforms=2, 3, 4397, isoforms=2, 3, 4466, isoforms=2, 3, 4480, isoforms=2, 3, 4529, posLast=614614, isoforms=2, 3, 4632, isoforms=2, 3, 4676, isoforms=2, 3, 4723, posLast=821821, isoforms=2, 3, 4827, posLast=10111011, isoforms=2, 3, 41028, and posLast=10751075

Other Protein References for TOP2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TOP2A (TOP2A)

Domains & Families for TOP2A Gene

Gene Families for TOP2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TOP2A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TOP2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11388

UniProtKB/Swiss-Prot:

TOP2A_HUMAN :
  • The N-terminus has several structural domains; the ATPase domain (about residues 1-265), the transducer domain (about 266-428) and the toprim domain (455-572) (PubMed:25202966). Comparing different structures shows ATP hydrolysis induces domain shifts in the N-terminus that are probably part of the mechanism of DNA cleavage and rejoining (PubMed:25202966).
  • Belongs to the type II topoisomerase family.
Domain:
  • The N-terminus has several structural domains; the ATPase domain (about residues 1-265), the transducer domain (about 266-428) and the toprim domain (455-572) (PubMed:25202966). Comparing different structures shows ATP hydrolysis induces domain shifts in the N-terminus that are probably part of the mechanism of DNA cleavage and rejoining (PubMed:25202966).
Family:
  • Belongs to the type II topoisomerase family.
genes like me logo Genes that share domains with TOP2A: view

Function for TOP2A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TOP2A Gene

GENATLAS Biochemistry:
DNA topoisomerase II alpha (170kDa),ubiquitous,markely upregulated in proliferating cells,catalyzing the ATP dependent breakage and rejoining of double strand of DNA,relaxing both positively and negatively supercoiled DNA,inhibited by Rb during cell cycle,target of several drugs widely used in the treatment of human cancers,including a variant associated with drug resistance,deleted or amplified simultaneously with ERBB2 in breast cancers
UniProtKB/Swiss-Prot CatalyticActivity:
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
UniProtKB/Swiss-Prot EnzymeRegulation:
Specifically inhibited by the intercalating agent amsacrine.
UniProtKB/Swiss-Prot Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).

Enzyme Numbers (IUBMB) for TOP2A Gene

Phenotypes From GWAS Catalog for TOP2A Gene

Gene Ontology (GO) - Molecular Function for TOP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 22323612
GO:0003677 DNA binding IEA,IDA 9049244
GO:0003682 chromatin binding IDA 9049244
GO:0003723 RNA binding IDA,HDA 22681889
GO:0003916 DNA topoisomerase activity IEA --
genes like me logo Genes that share ontologies with TOP2A: view
genes like me logo Genes that share phenotypes with TOP2A: view

Human Phenotype Ontology for TOP2A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TOP2A Gene

Localization for TOP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOP2A Gene

Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOP2A gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TOP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 colocalizes_with nuclear chromosome IDA 9049244
GO:0000793 condensed chromosome IEA --
GO:0005634 nucleus IEA,IDA 10788521
GO:0005654 nucleoplasm TAS --
GO:0005730 NOT nucleolus IDA 9049244
genes like me logo Genes that share ontologies with TOP2A: view

Pathways & Interactions for TOP2A Gene

genes like me logo Genes that share pathways with TOP2A: view

SIGNOR curated interactions for TOP2A Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for TOP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates IBA --
GO:0000819 sister chromatid segregation IBA --
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006259 DNA metabolic process IEA --
GO:0006265 DNA topological change IEA,IMP 12711669
genes like me logo Genes that share ontologies with TOP2A: view

Drugs & Compounds for TOP2A Gene

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  1. Drug

(94) Drugs for TOP2A Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Target, inhibitor Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1828
Etoposide Approved Pharma Target, inhibitor, Biomarker Topo II inhibitor, Topoisomerase 2 Inhibitors 1302
Teniposide Approved Pharma Target, inhibitor 21
Epirubicin Approved Pharma Target, inhibitor 426
Daunorubicin Approved Pharma Target, inhibitor DNA topoisomerase II inhibitor 291

(20) Additional Compounds for TOP2A Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Doxorubicin hydrochloride
25316-40-9

(4) Tocris Compounds for TOP2A Gene

Compound Action Cas Number
Dexrazoxane hydrochloride Topoisomerase II inhibitor 1263283-43-7
Doxorubicin hydrochloride Antitumor antibiotic agent. Inhibits DNA topoisomerase II 25316-40-9
Ellipticine Antitumor and intercalating agent; inhibits DNA topoisomerase II 519-23-3
Mitoxantrone dihydrochloride Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent 70476-82-3

(30) ApexBio Compounds for TOP2A Gene

Compound Action Cas Number
(S)-10-Hydroxycamptothecin 19685-09-7
Amonafide DNA intercalator,Topo II inhibitor 69408-81-7
Amrubicin Topoisomerase II inhibitor, anthracycline agent 110267-81-7
Amsacrine Topoisomerase 2 inhibitor 51264-14-3
Amsacrine hydrochloride Topoisomerase 2 inhibitor 54301-15-4
Beta-Lapachone DNA topoisomerase I inhibitor,selective 4707-32-8
Camptothecin Topoisomerase I inhibitor,prototypic 7689-03-4
Ciprofloxacin 85721-33-1
Daunorubicin DNA topoisomerase II inhibitor 20830-81-3
Dexrazoxane HCl (ICRF-187, ADR-529) Topoisomerase II inhibitor,intracellular ion chelator,cardioprotective agent 149003-01-0
Doxorubicin Topo II inhibitor,immunosuppresive antineoplastic antibiotic 23214-92-8
Doxorubicin (Adriamycin) HCl Antitumour antibiotic,inhibits TOPO II. 25316-40-9
Ellipticine DNA topoisomerase II inhibitor 519-23-3
Epirubicin HCl Antibiotic antitumor agent 56390-09-1
Etoposide Topo II inhibitor 33419-42-0
Flumequine 42835-25-6
Gatifloxacin Fluoroquinolone antibiotic,inhibits bacterial TOPO II 112811-59-3
Idarubicin HCl Anthracycline and daunorubicin analog,topoisomerase inhibitor 57852-57-0
INNO-206 Prodrug of doxorubicin 1361644-26-9
Irinotecan Topoisomerase I inhibitor 97682-44-5
Mitoxantrone HCl Topoisomerase II inhibitor, anti-neoplastic drug 70476-82-3
Moxifloxacin HCl Fluoroquinolone antibiotic 186826-86-8
Novobiocin Sodium 1476-53-5
Ofloxacin Fluoroquinolones,antibiotics 82419-36-1
Pirarubicin Topo II inhibitor;antineoplastic;analogue of doxorubicin 72496-41-4
Podophyllotoxin 518-28-5
Teniposide 29767-20-2
Topotecan HCl Topoisomerase 1 inhibitor 119413-54-6
Voreloxin Topo II inhibitor 175414-77-4
Voreloxin Hydrochloride Antineoplastic naphthyridine analogue 175519-16-1
genes like me logo Genes that share compounds with TOP2A: view

Drug Products

Transcripts for TOP2A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TOP2A Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(471) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOP2A Gene

Topoisomerase (DNA) II alpha 170kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOP2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: - -
SP2:
SP3:
SP4:

ExUns: 25b ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35
SP1:
SP2:
SP3:
SP4:

Relevant External Links for TOP2A Gene

GeneLoc Exon Structure for
TOP2A
ECgene alternative splicing isoforms for
TOP2A

Expression for TOP2A Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TOP2A Gene

mRNA expression in normal human tissues for TOP2A Gene
mRNA expression by GTEx for TOP2A GenemRNA expression by BioGPS for TOP2A Gene

mRNA differential expression in normal tissues according to GTEx for TOP2A Gene

This gene is overexpressed in Testis (x8.6).

Protein differential expression in normal tissues from HIPED for TOP2A Gene

This gene is overexpressed in Testis (22.3), Ovary (21.2), Nasal epithelium (8.3), and Lung (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TOP2A Gene



NURSA nuclear receptor signaling pathways regulating expression of TOP2A Gene:

TOP2A

SOURCE GeneReport for Unigene cluster for TOP2A Gene:

Hs.156346

Evidence on tissue expression from TISSUES for TOP2A Gene

  • Liver(3.7)
  • Nervous system(3.4)
  • Intestine(2.8)
  • Bone marrow(2.6)
  • Blood(2.4)
  • Lymph node(2.4)
  • Heart(2.2)
  • Lung(2.1)
  • Eye(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TOP2A Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • heart
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • adrenal gland
  • intestine
  • kidney
  • large intestine
  • small intestine
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • spinal cord
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with TOP2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TOP2A Gene

Orthologs for TOP2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOP2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TOP2A 33 34
  • 99 (n)
cow
(Bos Taurus)
 Mammalia TOP2A 33 34
  • 92.11 (n)
dog
(Canis familiaris)
 Mammalia TOP2A 33 34
  • 92.09 (n)
mouse
(Mus musculus)
 Mammalia Top2a 33 16 34
  • 87.14 (n)
rat
(Rattus norvegicus)
 Mammalia Top2a 33
  • 86.34 (n)
oppossum
(Monodelphis domestica)
 Mammalia TOP2A 34
  • 84 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia TOP2A 34
  • 79 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TOP2A 33 34
  • 72.54 (n)
lizard
(Anolis carolinensis)
 Reptilia TOP2A 34
  • 72 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia topoii 33
  • 69.8 (n)
African clawed frog
(Xenopus laevis)
 Amphibia LOC398512 33
zebrafish
(Danio rerio)
 Actinopterygii top2a 33 34
  • 66.05 (n)
wufc08c07 33
fruit fly
(Drosophila melanogaster)
 Insecta Top2 35 33 34
  • 59.99 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP008917 33
  • 58.92 (n)
worm
(Caenorhabditis elegans)
 Secernentea top-2 33 34
  • 59.67 (n)
F32A11.4 35
  • 59 (a)
F32A11.5 35
  • 54 (a)
ZK1127.7 35
  • 54 (a)
cin-4 34
  • 52 (a)
 ManyToMany
F31E8.6 35
  • 41 (a)
R05D3.1 35
  • 40 (a)
Y46H3C.4 35 34
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes TOP2 34
  • 43 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 63 (a)
 OneToMany
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.13260 33
Species where no ortholog for TOP2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOP2A Gene

ENSEMBL:
Gene Tree for TOP2A (if available)
TreeFam:
Gene Tree for TOP2A (if available)

Paralogs for TOP2A Gene

Paralogs for TOP2A Gene

(2) SIMAP similar genes for TOP2A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TOP2A: view

Variants for TOP2A Gene

Sequence variations from dbSNP and Humsavar for TOP2A Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs267607133 protective, Dna topoisomerase II, resistance to inhibition of, by amsacrine 40,408,007(-) C/T coding_sequence_variant, missense_variant
rs796052143 likely-benign, Long QT syndrome 40,416,427(-) A/G coding_sequence_variant, missense_variant
rs202201081 uncertain-significance, not specified 40,396,422(-) G/C coding_sequence_variant, missense_variant
rs1000055132 -- 40,397,183(-) G/T intron_variant
rs1000128067 -- 40,397,685(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TOP2A Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv833445 CNV loss 17160897

Variation tolerance for TOP2A Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.13; 61.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TOP2A Gene

Human Gene Mutation Database (HGMD)
TOP2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOP2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOP2A Gene

Disorders for TOP2A Gene

MalaCards: The human disease database

(15) MalaCards diseases for TOP2A Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
female breast cancer
  • female breast carcinoma
malignant peripheral nerve sheath tumor
  • neurofibrosarcoma
cervix endometriosis
  • cervical endometriosis
breast adenoid cystic carcinoma
  • adenoid cystic carcinoma of breast
trachea leiomyoma
  • leiomyoma of the trachea
- elite association - COSMIC cancer census association via MalaCards
Search TOP2A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TOP2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TOP2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOP2A Gene

Publications for TOP2A Gene

  1. Association between HER2, TOP2A, and response to anthracycline-based preoperative chemotherapy in high-risk primary breast cancer. (PMID: 20130985) Konecny GE … Slamon DJ (Breast cancer research and treatment 2010) 3 22 44 58
  2. Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy. (PMID: 19401546) O'Malley FP … Pritchard KI (Journal of the National Cancer Institute 2009) 3 22 44 58
  3. Outcome of patients with early-stage breast cancer treated with doxorubicin-based adjuvant chemotherapy as a function of HER2 and TOP2A status. (PMID: 19620488) Tubbs R … Hayes DF (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009) 3 22 44 58
  4. Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia. (PMID: 16507781) Monzo M … CETLAM (Blood 2006) 3 22 44 58
  5. retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group. (PMID: 16234514) Knoop AS … Danish Breast Cancer Cooperative Group (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005) 3 22 25 58

Products for TOP2A Gene