This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding m... See more...

Aliases for TOP1MT Gene

Aliases for TOP1MT Gene

  • DNA Topoisomerase I Mitochondrial 2 3 5
  • Topoisomerase (DNA) I, Mitochondrial 2 3
  • DNA Topoisomerase I, Mitochondrial 3 4
  • Mitochondrial Topoisomerase IB 3
  • EC 5.99.1.2 51
  • EC 5.6.2.1 4
  • TOP1MT 5
  • TOP1mt 4

External Ids for TOP1MT Gene

Previous GeneCards Identifiers for TOP1MT Gene

  • GC08M142583
  • GC08U900001
  • GC08M144166
  • GC08M144496
  • GC08M144463
  • GC08M144391
  • GC08M139629

Summaries for TOP1MT Gene

Entrez Gene Summary for TOP1MT Gene

  • This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for TOP1MT Gene

TOP1MT (DNA Topoisomerase I Mitochondrial) is a Protein Coding gene. Diseases associated with TOP1MT include Spinocerebellar Ataxia Type 1 With Axonal Neuropathy and Brown-Vialetto-Van Laere Syndrome. Gene Ontology (GO) annotations related to this gene include DNA topoisomerase type I activity and DNA topoisomerase type II (ATP-hydrolyzing) activity. An important paralog of this gene is TOP1.

UniProtKB/Swiss-Prot Summary for TOP1MT Gene

  • Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).

Additional gene information for TOP1MT Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TOP1MT Gene

Genomics for TOP1MT Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TOP1MT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J143333 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 620.6 +25.2 25245 2.2 HNRNPL CREB1 GATAD2A ZBTB33 PRDM10 REST TFE3 IKZF1 ZNF692 BACH1 TOP1MT lnc-MAFA-5 RHPN1 ENSG00000253931 MAFA-AS1 LY6H MINCR piR-57135-105 ZNF696
GH08J143360 Enhancer 0.4 FANTOM5 ENCODE 600.7 -1.0 -997 0.2 TOP1MT lnc-TOP1MT-3 piR-43499 RHPN1
GH08J143359 Promoter 0.3 EPDnew 600.7 0.0 -48 0.1 TOP1MT lnc-TOP1MT-3 piR-43499 RHPN1
GH08J143358 Enhancer 0.2 Ensembl 600.7 +1.1 1078 0.2 TOP1MT lnc-TOP1MT-3 RF00017-7369 ZNF696
GH08J143367 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 17.3 -8.9 -8861 3.3 SP1 CREB1 PRDM10 TFE3 RFX1 ZNF692 FOS LARP7 DDX20 ZIC2 RHPN1 RHPN1-AS1 TOP1MT ZNF623 ZNF707 SLC52A2 GPAA1 JRK ZNF696 FBXL6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TOP1MT on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TOP1MT

Top Transcription factor binding sites by QIAGEN in the TOP1MT gene promoter:
  • AML1a
  • AP-1
  • Cdc5
  • GATA-1
  • GATA-2
  • GATA-3
  • HEN1
  • Lmo2
  • Nkx2-5
  • RFX1

Genomic Locations for TOP1MT Gene

Genomic Locations for TOP1MT Gene
chr8:143,304,384-143,359,979
(GRCh38/hg38)
Size:
55,596 bases
Orientation:
Minus strand
chr8:144,386,554-144,442,149
(GRCh37/hg19)
Size:
55,596 bases
Orientation:
Minus strand

Genomic View for TOP1MT Gene

Genes around TOP1MT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOP1MT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOP1MT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOP1MT Gene

Proteins for TOP1MT Gene

  • Protein details for TOP1MT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969P6-TOP1M_HUMAN
    Recommended name:
    DNA topoisomerase I, mitochondrial
    Protein Accession:
    Q969P6
    Secondary Accessions:
    • B7ZAR5
    • E7ES89
    • Q86ST4
    • Q86V82

    Protein attributes for TOP1MT Gene

    Size:
    601 amino acids
    Molecular mass:
    69872 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH44646.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TOP1MT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOP1MT Gene

Selected DME Specific Peptides for TOP1MT Gene

Q969P6:
  • GLTAKVFRTYNAS
  • LRAGNEK
  • AKILSYNRANR
  • VAILCNHQ
  • KNLQLFMENK
  • HPKMGMLKRRI
  • ADTVGCC

Post-translational modifications for TOP1MT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TOP1MT Gene

Gene Families for TOP1MT Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for TOP1MT Gene

Suggested Antigen Peptide Sequences for TOP1MT Gene

GenScript: Design optimal peptide antigens:
  • Topoisomerase (DNA) I, mitochondrial, isoform CRA_a (D3DWJ7_HUMAN)
  • TOP1MT protein (Q8TBP3_HUMAN)
  • DNA topoisomerase I, mitochondrial (TOP1M_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969P6

UniProtKB/Swiss-Prot:

TOP1M_HUMAN :
  • Belongs to the type IB topoisomerase family.
Family:
  • Belongs to the type IB topoisomerase family.
genes like me logo Genes that share domains with TOP1MT: view

Function for TOP1MT Gene

Molecular function for TOP1MT Gene

UniProtKB/Swiss-Prot Function:
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.; EC=5.6.2.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10130};.

Enzyme Numbers (IUBMB) for TOP1MT Gene

Phenotypes From GWAS Catalog for TOP1MT Gene

Gene Ontology (GO) - Molecular Function for TOP1MT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003916 DNA topoisomerase activity IEA --
GO:0003917 DNA topoisomerase type I activity IEA,IBA 21873635
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with TOP1MT: view
genes like me logo Genes that share phenotypes with TOP1MT: view

Animal Models for TOP1MT Gene

MGI Knock Outs for TOP1MT:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOP1MT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOP1MT Gene

Localization for TOP1MT Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOP1MT Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOP1MT gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TOP1MT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005739 mitochondrion IDA --
GO:0042645 mitochondrial nucleoid IBA,IDA 18063578
genes like me logo Genes that share ontologies with TOP1MT: view

Pathways & Interactions for TOP1MT Gene

PathCards logo

SuperPathways for TOP1MT Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOP1MT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IBA 21873635
GO:0006265 DNA topological change IEA,IBA 21873635
genes like me logo Genes that share ontologies with TOP1MT: view

No data available for Pathways by source and SIGNOR curated interactions for TOP1MT Gene

Drugs & Compounds for TOP1MT Gene

(12) Drugs for TOP1MT Gene - From: DrugBank, ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Irinotecan Approved, Investigational Pharma Target, inhibitor, Biomarker Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1414
Topotecan Approved, Investigational Pharma Target, inhibitor, Biomarker Topoisomerase 1 inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 384
Magnesium Approved, Experimental, Investigational Pharma 0
Camptothecin Experimental Pharma Topoisomerase I inhibitor,prototypic 119
(S)-10-Hydroxycamptothecin Pharma 0

(7) ApexBio Compounds for TOP1MT Gene

Compound Action Cas Number
(S)-10-Hydroxycamptothecin 19685-09-7
Beta-Lapachone DNA topoisomerase I inhibitor,selective 4707-32-8
Camptothecin Topoisomerase I inhibitor,prototypic 7689-03-4
Idarubicin HCl Anthracycline and daunorubicin analog,topoisomerase inhibitor 57852-57-0
Irinotecan Topoisomerase I inhibitor 97682-44-5
Irinotecan HCl Trihydrate TOPO 1 inhibitor 136572-09-3
Topotecan HCl Topoisomerase 1 inhibitor 119413-54-6
genes like me logo Genes that share compounds with TOP1MT: view

Drug Products

Transcripts for TOP1MT Gene

mRNA/cDNA for TOP1MT Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOP1MT

Alternative Splicing Database (ASD) splice patterns (SP) for TOP1MT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for TOP1MT Gene

GeneLoc Exon Structure for
TOP1MT

Expression for TOP1MT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TOP1MT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TOP1MT Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TOP1MT Gene



Protein tissue co-expression partners for TOP1MT Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TOP1MT

SOURCE GeneReport for Unigene cluster for TOP1MT Gene:

Hs.528574

mRNA Expression by UniProt/SwissProt for TOP1MT Gene:

Q969P6-TOP1M_HUMAN
Tissue specificity: Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.

Evidence on tissue expression from TISSUES for TOP1MT Gene

  • Nervous system(4.7)
  • Lung(4.3)
  • Intestine(2.3)
  • Liver(2.3)
  • Heart(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with TOP1MT: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOP1MT Gene

Orthologs for TOP1MT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TOP1MT Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TOP1MT 30 31
  • 98.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Top1mt 30
  • 78.49 (n)
Mouse
(Mus musculus)
Mammalia Top1mt 30 17 31
  • 78.07 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 76 (a)
OneToMany
-- 31
  • 69 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
-- 31
  • 23 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia TOP1MT 31
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TOP1MT 30 31
  • 73.56 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TOP1MT 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia top1mt 30
  • 73.93 (n)
Zebrafish
(Danio rerio)
Actinopterygii top1mt 30 31
  • 67.76 (n)
OneToMany
CABZ01090980.1 31
  • 31 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Top1 31 32
  • 35 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea top-1 31
  • 41 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOP1 31 33
  • 35 (a)
OneToMany
Barley
(Hordeum vulgare)
Liliopsida Hv.6555 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8887 31
  • 54 (a)
OneToMany
Species where no ortholog for TOP1MT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TOP1MT Gene

ENSEMBL:
Gene Tree for TOP1MT (if available)
TreeFam:
Gene Tree for TOP1MT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TOP1MT: view image

Paralogs for TOP1MT Gene

Paralogs for TOP1MT Gene

(1) SIMAP similar genes for TOP1MT Gene using alignment to 14 proteins:

  • TOP1M_HUMAN
  • D3DWJ7_HUMAN
  • E5RFE3_HUMAN
  • E5RFS0_HUMAN
  • E5RGE7_HUMAN
  • E5RGR2_HUMAN
  • E5RGR4_HUMAN
  • E5RIC7_HUMAN
  • E5RJ33_HUMAN
  • E5RJ95_HUMAN
  • H0YAR3_HUMAN
  • H0YBR3_HUMAN
  • H0YC03_HUMAN
  • Q8TBP3_HUMAN
genes like me logo Genes that share paralogs with TOP1MT: view

Variants for TOP1MT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TOP1MT Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
717294 Benign: not provided 143,309,548(-) G/A INTRON_VARIANT
rs11544484 - p.Val256Ile
rs2293925 - p.Arg525Trp

Additional dbSNP identifiers (rs#s) for TOP1MT Gene

Structural Variations from Database of Genomic Variants (DGV) for TOP1MT Gene

Variant ID Type Subtype PubMed ID
dgv1240e201 CNV deletion 23290073
dgv3929n106 CNV deletion 24896259
esv1001481 CNV deletion 20482838
esv1002171 CNV deletion 20482838
esv1306243 CNV deletion 17803354
esv1540362 CNV insertion 17803354
esv1659436 CNV insertion 17803354
esv1662735 CNV insertion 17803354
esv1753050 CNV insertion 17803354
esv2147503 CNV deletion 18987734
esv2671574 CNV deletion 23128226
esv2678203 CNV deletion 23128226
esv2737992 CNV deletion 23290073
esv2737993 CNV deletion 23290073
esv2737994 CNV deletion 23290073
esv2737996 CNV deletion 23290073
esv2737997 CNV deletion 23290073
esv2737998 CNV deletion 23290073
esv2737999 CNV deletion 23290073
esv2738000 CNV deletion 23290073
esv2738002 CNV deletion 23290073
esv2738003 CNV deletion 23290073
esv2738004 CNV deletion 23290073
esv2741638 CNV deletion 23290073
esv3349116 CNV duplication 20981092
esv3543 CNV loss 18987735
esv3544383 CNV deletion 23714750
esv3544384 CNV deletion 23714750
esv3573029 CNV loss 25503493
esv3573030 CNV loss 25503493
esv3619106 CNV gain 21293372
esv3619107 CNV gain 21293372
esv3619108 CNV loss 21293372
nsv1016726 CNV loss 25217958
nsv1075596 CNV deletion 25765185
nsv1147797 CNV deletion 26484159
nsv470247 CNV loss 18288195
nsv472173 CNV novel sequence insertion 20440878
nsv950010 CNV deletion 24416366
nsv950012 CNV deletion 24416366

Variation tolerance for TOP1MT Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.40; 92.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TOP1MT Gene

Human Gene Mutation Database (HGMD)
TOP1MT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOP1MT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOP1MT Gene

Disorders for TOP1MT Gene

MalaCards: The human disease database

(2) MalaCards diseases for TOP1MT Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinocerebellar ataxia type 1 with axonal neuropathy
  • scan1
brown-vialetto-van laere syndrome
  • pontobulbar palsy with deafness
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TOP1MT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TOP1MT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOP1MT Gene

Publications for TOP1MT Gene

  1. Human mitochondrial topoisomerase I. (PMID: 11526219) Zhang H … Pommier Y (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 23
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 41
  4. Mitochondrial topoisomerase I sites in the regulatory D-loop region of mitochondrial DNA. (PMID: 18826252) Zhang H … Pommier Y (Biochemistry 2008) 3 23
  5. Immunological identification of human platelet mitochondrial DNA topoisomerase I. (PMID: 8390858) Kosovsky MJ … Soslau G (Biochimica et biophysica acta 1993) 23 26

Products for TOP1MT Gene

Sources for TOP1MT Gene