Aliases for TONSL Gene
External Ids for TONSL Gene
Previous HGNC Symbols for TONSL Gene
Previous GeneCards Identifiers for TONSL Gene
The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]
GeneCards Summary for TONSL Gene
TONSL (Tonsoku Like, DNA Repair Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and histone binding. An important paralog of this gene is ANKRD31.
UniProtKB/Swiss-Prot for TONSL Gene
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.