Aliases for TOMM70 Gene
External Ids for TOMM70 Gene
Previous HGNC Symbols for TOMM70 Gene
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011]
GeneCards Summary for TOMM70 Gene
TOMM70 (Translocase Of Outer Mitochondrial Membrane 70) is a Protein Coding gene. Diseases associated with TOMM70 include Spastic Ataxia 5 and Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 1. Among its related pathways are Mitochondrial protein import and Deubiquitination. An important paralog of this gene is RPAP3.
UniProtKB/Swiss-Prot Summary for TOMM70 Gene
Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812).