The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity a... See more...

Aliases for TOMM34 Gene

Aliases for TOMM34 Gene

  • Translocase Of Outer Mitochondrial Membrane 34 2 3 5
  • Outer Mitochondrial Membrane Translocase (34kD) 2 3
  • Translocase Of Outer Membrane 34 KDa Subunit 3 4
  • Mitochondrial Import Receptor Subunit TOM34 3 4
  • HTOM34P 2 3
  • HTom34 3 4
  • TOM34 2 3
  • URCC3 3 4
  • TOMM34 5

External Ids for TOMM34 Gene

Previous GeneCards Identifiers for TOMM34 Gene

  • GC20M043299
  • GC20M043259
  • GC20M044209
  • GC20M044256
  • GC20M043004
  • GC20M043570
  • GC20M040312

Summaries for TOMM34 Gene

Entrez Gene Summary for TOMM34 Gene

  • The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]

GeneCards Summary for TOMM34 Gene

TOMM34 (Translocase Of Outer Mitochondrial Membrane 34) is a Protein Coding gene. Diseases associated with TOMM34 include Combined Oxidative Phosphorylation Deficiency 3. Gene Ontology (GO) annotations related to this gene include heat shock protein binding. An important paralog of this gene is SPAG1.

UniProtKB/Swiss-Prot Summary for TOMM34 Gene

  • Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.

Gene Wiki entry for TOMM34 Gene

Additional gene information for TOMM34 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TOMM34 Gene

Genomics for TOMM34 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TOMM34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J044958 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 639.5 +0.3 316 2.9 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 LEF1 IKZF1 NFKBIZ POLR2A TOMM34 lnc-PABPC1L-4 PABPC1L HSALNG0130350
GH20J044961 Promoter/Enhancer 1.1 Ensembl ENCODE 600.7 -1.7 -1706 0.9 IKZF1 KDM1A BACH1 JUND DPF2 ZNF341 EP300 CBX3 TCF7L2 EGR1 TOMM34 lnc-PABPC1L-4 STK4 STK4-AS1
GH20J044909 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.7 +49.7 49680 2.9 HNRNPL GATAD2A CTCF PRDM10 ZNF629 TFE3 RFX1 IKZF1 POLR2A ZNF692 PABPC1L YWHAB ENSG00000271984 JPH2 TOMM34 STK4 STK4-AS1 ZSWIM1 DBNDD2 piR-57460-413
GH20J044965 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.2 -8.5 -8501 7.5 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 REST TFE3 STK4 STK4-AS1 PCIF1 SYS1 ENSG00000271984 ZSWIM1 UBE2C PABPC1L ZSWIM3 WFDC5
GH20J045010 Enhancer 1.2 Ensembl ENCODE dbSUPER 12 -54.0 -53976 9.6 CTCF TEAD4 PRDM10 ZNF629 ZNF692 FOXA1 PRDM1 ZSCAN4 REST RAD21 STK4 STK4-AS1 TOMM34 PABPC1L KCNS1 ENSG00000252021 RF00782
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TOMM34 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TOMM34

Top Transcription factor binding sites by QIAGEN in the TOMM34 gene promoter:
  • AML1a
  • GATA-1
  • Ik-3
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Pbx1a

Genomic Locations for TOMM34 Gene

Genomic Locations for TOMM34 Gene
chr20:44,942,130-44,960,425
(GRCh38/hg38)
Size:
18,296 bases
Orientation:
Minus strand
chr20:43,570,771-43,589,127
(GRCh37/hg19)
Size:
18,357 bases
Orientation:
Minus strand

Genomic View for TOMM34 Gene

Genes around TOMM34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM34 Gene

Proteins for TOMM34 Gene

  • Protein details for TOMM34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15785-TOM34_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM34
    Protein Accession:
    Q15785
    Secondary Accessions:
    • Q53GH9
    • Q6IBN7
    • Q9NTZ3

    Protein attributes for TOMM34 Gene

    Size:
    309 amino acids
    Molecular mass:
    34559 Da
    Quaternary structure:
    • Interacts with HSP90A, VCP, ATP6M, KIAA0665, AMPK, and DMAP1 through its TPR repeat.

neXtProt entry for TOMM34 Gene

Post-translational modifications for TOMM34 Gene

  • Ubiquitination at Lys278
  • Modification sites at PhosphoSitePlus

Other Protein References for TOMM34 Gene

No data available for DME Specific Peptides for TOMM34 Gene

Domains & Families for TOMM34 Gene

Gene Families for TOMM34 Gene

Protein Domains for TOMM34 Gene

Suggested Antigen Peptide Sequences for TOMM34 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ26027 fis, clone PNC04328, highly similar to Homo sapiens translocase of outer mitochondrial membrane 34 (TOMM34) (Q6ZPD0_HUMAN)
  • Translocase of outer membrane 34 kDa subunit (TOM34_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15785

UniProtKB/Swiss-Prot:

TOM34_HUMAN :
  • Belongs to the Tom34 family.
Family:
  • Belongs to the Tom34 family.
genes like me logo Genes that share domains with TOMM34: view

Function for TOMM34 Gene

Molecular function for TOMM34 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.

Phenotypes From GWAS Catalog for TOMM34 Gene

Gene Ontology (GO) - Molecular Function for TOMM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0031072 heat shock protein binding IBA,IPI 9660753
genes like me logo Genes that share ontologies with TOMM34: view
genes like me logo Genes that share phenotypes with TOMM34: view

Animal Models for TOMM34 Gene

MGI Knock Outs for TOMM34:

Animal Model Products

CRISPR Products

miRNA for TOMM34 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOMM34

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOMM34 Gene

Localization for TOMM34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM34 Gene

Cytoplasm. Mitochondrion outer membrane. Peripheral membrane protein. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOMM34 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TOMM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IBA 21873635
GO:0005741 mitochondrial outer membrane IEA,IDA 9324309
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with TOMM34: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TOMM34 Gene

Pathways & Interactions for TOMM34 Gene

PathCards logo

SuperPathways for TOMM34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOMM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion IBA,IMP 9324309
genes like me logo Genes that share ontologies with TOMM34: view

No data available for Pathways by source and SIGNOR curated interactions for TOMM34 Gene

Drugs & Compounds for TOMM34 Gene

(4) Drugs for TOMM34 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
leucovorin Approved Pharma 3692,1548
Levoleucovorin Approved, Investigational Pharma 948
Tegafur Approved, Investigational Pharma 132
Vaccines Pharma 8100
genes like me logo Genes that share compounds with TOMM34: view

Transcripts for TOMM34 Gene

mRNA/cDNA for TOMM34 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOMM34

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM34 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: -

Relevant External Links for TOMM34 Gene

GeneLoc Exon Structure for
TOMM34

Expression for TOMM34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TOMM34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOMM34 Gene

This gene is overexpressed in Testis (x4.9).

Protein differential expression in normal tissues from HIPED for TOMM34 Gene

This gene is overexpressed in Testis (10.7), Fetal ovary (8.4), Ovary (8.3), and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TOMM34 Gene



Protein tissue co-expression partners for TOMM34 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TOMM34

SOURCE GeneReport for Unigene cluster for TOMM34 Gene:

Hs.517066

mRNA Expression by UniProt/SwissProt for TOMM34 Gene:

Q15785-TOM34_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TOMM34 Gene

  • Nervous system(4.5)
  • Kidney(4.5)
  • Skin(4.5)
  • Muscle(4.4)
  • Liver(4.4)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with TOMM34: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TOMM34 Gene

Orthologs for TOMM34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOMM34 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TOMM34 30 31
  • 99.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tomm34 30
  • 89.1 (n)
Mouse
(Mus musculus)
Mammalia Tomm34 30 17 31
  • 88.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TOMM34 30 31
  • 87.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TOMM34 30 31
  • 86.52 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TOMM34 31
  • 56 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 43 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves TOMM34 30 31
  • 64.17 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TOMM34 31
  • 64 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii tomm34 30 31
  • 58.53 (n)
OneToOne
wufb96b08 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG18472 31
  • 11 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM70 31
  • 12 (a)
ManyToMany
TOM71 31
  • 10 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.524 31
  • 12 (a)
OneToMany
Species where no ortholog for TOMM34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TOMM34 Gene

ENSEMBL:
Gene Tree for TOMM34 (if available)
TreeFam:
Gene Tree for TOMM34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TOMM34: view image

Paralogs for TOMM34 Gene

(1) SIMAP similar genes for TOMM34 Gene using alignment to 1 proteins:

  • TOM34_HUMAN
genes like me logo Genes that share paralogs with TOMM34: view

Variants for TOMM34 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TOMM34 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs6094061 - p.Arg293Lys

Additional dbSNP identifiers (rs#s) for TOMM34 Gene

Structural Variations from Database of Genomic Variants (DGV) for TOMM34 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958
nsv518547 CNV gain 19592680
nsv586077 CNV gain 21841781

Variation tolerance for TOMM34 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TOMM34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOMM34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM34 Gene

Disorders for TOMM34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TOMM34 Gene - From: DISEASES

Disorder Aliases PubMed IDs
combined oxidative phosphorylation deficiency 3
  • coxpd3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TOMM34

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TOMM34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOMM34 Gene

Publications for TOMM34 Gene

  1. hTom34: a novel translocase for the import of proteins into human mitochondria. (PMID: 9324309) Nuttall SD … Hoogenraad NJ (DNA and cell biology 1997) 2 3 4 23
  2. Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol. (PMID: 11913976) Yang CS … Weiner H (Archives of biochemistry and biophysics 2002) 3 4 23
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  5. Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target. (PMID: 16820880) Shimokawa T … Furukawa Y (International journal of oncology 2006) 3 4

Products for TOMM34 Gene

  • Signalway Proteins for TOMM34

Sources for TOMM34 Gene