The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008] See more...

Aliases for TOMM22 Gene

Aliases for TOMM22 Gene

  • Translocase Of Outer Mitochondrial Membrane 22 2 3 5
  • TOM22 2 3 4
  • Translocase Of Outer Membrane 22 KDa Subunit Homolog 3 4
  • Mitochondrial Import Receptor Subunit TOM22 Homolog 3 4
  • 1C9-2 3 4
  • Translocase Of Outer Mitochondrial Membrane 22 Homolog (Yeast) 2
  • Translocase Of Outer Mitochondrial Membrane 22 Homolog 3
  • Mitochondrial Import Receptor Tom22 3
  • MSTP065 3
  • MST065 3
  • TOMM22 5
  • HTom22 4

External Ids for TOMM22 Gene

Previous GeneCards Identifiers for TOMM22 Gene

  • GC22P035692
  • GC22P037321
  • GC22P037402
  • GC22P039077
  • GC22P022044

Summaries for TOMM22 Gene

Entrez Gene Summary for TOMM22 Gene

  • The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]

GeneCards Summary for TOMM22 Gene

TOMM22 (Translocase Of Outer Mitochondrial Membrane 22) is a Protein Coding gene. Diseases associated with TOMM22 include 3-Methylglutaconic Aciduria, Type V. Among its related pathways are Metabolism of proteins and Mitophagy. Gene Ontology (GO) annotations related to this gene include protein transmembrane transporter activity.

UniProtKB/Swiss-Prot Summary for TOMM22 Gene

  • Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (PubMed:10982837). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity).

Gene Wiki entry for TOMM22 Gene

Additional gene information for TOMM22 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TOMM22 Gene

Genomics for TOMM22 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TOMM22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TOMM22 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TOMM22

Top Transcription factor binding sites by QIAGEN in the TOMM22 gene promoter:
  • AML1a
  • FOXD1
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • SRY

Genomic Locations for TOMM22 Gene

Genomic Locations for TOMM22 Gene
chr22:38,681,957-38,685,421
(GRCh38/hg38)
Size:
3,465 bases
Orientation:
Plus strand
chr22:39,077,953-39,080,818
(GRCh37/hg19)
Size:
2,866 bases
Orientation:
Plus strand

Genomic View for TOMM22 Gene

Genes around TOMM22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM22 Gene

Proteins for TOMM22 Gene

  • Protein details for TOMM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS69-TOM22_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM22 homolog
    Protein Accession:
    Q9NS69

    Protein attributes for TOMM22 Gene

    Size:
    142 amino acids
    Molecular mass:
    15522 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70) (PubMed:18331822). Interacts with TOMM40. Interacts with PPP2R2B (By similarity).

neXtProt entry for TOMM22 Gene

Post-translational modifications for TOMM22 Gene

  • Ubiquitination at Lys141
  • Modification sites at PhosphoSitePlus

Other Protein References for TOMM22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOMM22 Gene

Domains & Families for TOMM22 Gene

Gene Families for TOMM22 Gene

Protein Domains for TOMM22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOMM22 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92357, Homo sapiens translocase of outer mitochondrial membrane 22 homolog(yeast) (TOMM22), mRNA (Q549C5_HUMAN)
  • Translocase of outer membrane 22 kDa subunit homolog (TOM22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NS69

UniProtKB/Swiss-Prot:

TOM22_HUMAN :
  • Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins.
  • Belongs to the Tom22 family.
Domain:
  • Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins.
Family:
  • Belongs to the Tom22 family.
genes like me logo Genes that share domains with TOMM22: view

Function for TOMM22 Gene

Molecular function for TOMM22 Gene

UniProtKB/Swiss-Prot Function:
Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (PubMed:10982837). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity).

Phenotypes From GWAS Catalog for TOMM22 Gene

Gene Ontology (GO) - Molecular Function for TOMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12198123
GO:0008320 protein transmembrane transporter activity IEA,TAS 15644312
genes like me logo Genes that share ontologies with TOMM22: view
genes like me logo Genes that share phenotypes with TOMM22: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOMM22

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOMM22 Gene

Localization for TOMM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM22 Gene

Mitochondrion outer membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOMM22 gene
Compartment Confidence
mitochondrion 5
cytosol 4
extracellular 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TOMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005742 mitochondrial outer membrane translocase complex IEA,IDA 12198123
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IDA 15644312
genes like me logo Genes that share ontologies with TOMM22: view

Pathways & Interactions for TOMM22 Gene

genes like me logo Genes that share pathways with TOMM22: view

Pathways by source for TOMM22 Gene

Gene Ontology (GO) - Biological Process for TOMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion IEA,TAS 14557246
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0016236 macroautophagy TAS --
GO:0043065 positive regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with TOMM22: view

No data available for SIGNOR curated interactions for TOMM22 Gene

Drugs & Compounds for TOMM22 Gene

No Compound Related Data Available

Transcripts for TOMM22 Gene

mRNA/cDNA for TOMM22 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOMM22

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM22 Gene

No ASD Table

Relevant External Links for TOMM22 Gene

GeneLoc Exon Structure for
TOMM22

Expression for TOMM22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TOMM22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TOMM22 Gene

This gene is overexpressed in Nasal epithelium (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TOMM22 Gene



Protein tissue co-expression partners for TOMM22 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TOMM22

SOURCE GeneReport for Unigene cluster for TOMM22 Gene:

Hs.595072

mRNA Expression by UniProt/SwissProt for TOMM22 Gene:

Q9NS69-TOM22_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TOMM22 Gene

  • Liver(4.5)
  • Nervous system(3.8)
  • Lung(3.4)
  • Muscle(2.5)
  • Skin(2.5)
  • Heart(2.4)
  • Kidney(2.4)
  • Adrenal gland(2.1)
  • Blood(2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with TOMM22: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOMM22 Gene

Orthologs for TOMM22 Gene

This gene was present in the common ancestor of animals.

Orthologs for TOMM22 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TOMM22 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 95 (a)
OneToMany
-- 31
  • 90 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia TOMM22 30 31
  • 91.93 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tomm22 30 17 31
  • 89.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tomm22 30
  • 89.06 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TOMM22 31
  • 82 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 80 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
Chicken
(Gallus gallus)
Aves TOMM22 31
  • 51 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TOMM22 31
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tomm22 30
  • 66.67 (n)
Str.6735 30
Zebrafish
(Danio rerio)
Actinopterygii tomm22 31
  • 65 (a)
OneToOne
wufa02g11 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7281 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005376 30
  • 53.61 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta mge 30 31
  • 52.98 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea tomm-22 31
  • 34 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 53 (a)
OneToOne
Species where no ortholog for TOMM22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TOMM22 Gene

ENSEMBL:
Gene Tree for TOMM22 (if available)
TreeFam:
Gene Tree for TOMM22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TOMM22: view image

Paralogs for TOMM22 Gene

(1) SIMAP similar genes for TOMM22 Gene using alignment to 1 proteins:

  • TOM22_HUMAN
genes like me logo Genes that share paralogs with TOMM22: view

No data available for Paralogs for TOMM22 Gene

Variants for TOMM22 Gene

Additional dbSNP identifiers (rs#s) for TOMM22 Gene

Structural Variations from Database of Genomic Variants (DGV) for TOMM22 Gene

Variant ID Type Subtype PubMed ID
nsv508733 CNV insertion 20534489

Variation tolerance for TOMM22 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TOMM22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOMM22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TOMM22 Gene

Disorders for TOMM22 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TOMM22 Gene - From: DISEASES

Disorder Aliases PubMed IDs
3-methylglutaconic aciduria, type v
  • mgca5
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TOMM22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TOMM22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOMM22 Gene

Publications for TOMM22 Gene

  1. Identification and functional analysis of human Tom22 for protein import into mitochondria. (PMID: 10982837) Yano M … Mori M (Molecular and cellular biology 2000) 2 3 4 23
  2. Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane. (PMID: 10900208) Saeki K … Mihara K (The Journal of biological chemistry 2000) 2 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  4. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PMID: 18331822) Kato H … Mihara K (Biochemical and biophysical research communications 2008) 4 23
  5. TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. (PMID: 17096026) Bellot G … Vallette FM (Cell death and differentiation 2007) 3 23

Products for TOMM22 Gene

  • Signalway ELISA kits for TOMM22

Sources for TOMM22 Gene