Aliases for TOMM22 Gene
External Ids for TOMM22 Gene
Previous GeneCards Identifiers for TOMM22 Gene
The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]
GeneCards Summary for TOMM22 Gene
TOMM22 (Translocase Of Outer Mitochondrial Membrane 22) is a Protein Coding gene. Diseases associated with TOMM22 include 3-Methylglutaconic Aciduria, Type V. Among its related pathways are Metabolism of proteins and Mitophagy. Gene Ontology (GO) annotations related to this gene include protein transmembrane transporter activity.
UniProtKB/Swiss-Prot Summary for TOMM22 Gene
Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (PubMed:10982837). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity).