Aliases for TOMM20L Gene

Aliases for TOMM20L Gene

  • Translocase Of Outer Mitochondrial Membrane 20 Like 2 3 5
  • Translocase Of Outer Mitochondrial Membrane 20 Homolog Type I 2 3
  • TOMM20-Like Protein 1 3 4
  • Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)-Like 2
  • Translocase Of Outer Mitochondrial Membrane 20 Homolog-Like 3
  • UNQ9438 3

External Ids for TOMM20L Gene

Previous GeneCards Identifiers for TOMM20L Gene

  • GC14P057933
  • GC14P058862
  • GC14P039027

Summaries for TOMM20L Gene

GeneCards Summary for TOMM20L Gene

TOMM20L (Translocase Of Outer Mitochondrial Membrane 20 Like) is a Protein Coding gene. Diseases associated with TOMM20L include Mitochondrial Complex I Deficiency, Nuclear Type 1. An important paralog of this gene is TOMM20.

Additional gene information for TOMM20L Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TOMM20L Gene

Genomics for TOMM20L Gene

GeneHancer (GH) Regulatory Elements for TOMM20L Gene

Promoters and enhancers for TOMM20L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TOMM20L on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TOMM20L

Top Transcription factor binding sites by QIAGEN in the TOMM20L gene promoter:
  • AREB6
  • FOXJ2
  • FOXJ2 (long isoform)
  • HNF-4alpha1
  • HNF-4alpha2
  • LUN-1
  • Nkx2-5
  • p53
  • POU6F1 (c2)
  • Sox5

Genomic Locations for TOMM20L Gene

Genomic Locations for TOMM20L Gene
chr14:58,395,926-58,417,080
(GRCh38/hg38)
Size:
21,155 bases
Orientation:
Plus strand
chr14:58,862,634-58,875,419
(GRCh37/hg19)
Size:
12,786 bases
Orientation:
Plus strand

Genomic View for TOMM20L Gene

Genes around TOMM20L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM20L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM20L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM20L Gene

Proteins for TOMM20L Gene

  • Protein details for TOMM20L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXN7-TO20L_HUMAN
    Recommended name:
    TOMM20-like protein 1
    Protein Accession:
    Q6UXN7
    Secondary Accessions:
    • B2RPR0

    Protein attributes for TOMM20L Gene

    Size:
    152 amino acids
    Molecular mass:
    17700 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TOMM20L Gene

Post-translational modifications for TOMM20L Gene

No Post-translational modifications

Other Protein References for TOMM20L Gene

No data available for DME Specific Peptides for TOMM20L Gene

Domains & Families for TOMM20L Gene

Gene Families for TOMM20L Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TOMM20L Gene

Blocks:
  • MAS20 protein import receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOMM20L Gene

GenScript: Design optimal peptide antigens:
  • TOMM20-like protein 1 (TO20L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UXN7

UniProtKB/Swiss-Prot:

TO20L_HUMAN :
  • Belongs to the Tom20 family.
Family:
  • Belongs to the Tom20 family.
genes like me logo Genes that share domains with TOMM20L: view

Function for TOMM20L Gene

Phenotypes From GWAS Catalog for TOMM20L Gene

Gene Ontology (GO) - Molecular Function for TOMM20L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008320 contributes_to protein transmembrane transporter activity IBA 21873635
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IBA 21873635
GO:0030943 mitochondrion targeting sequence binding IBA 21873635
genes like me logo Genes that share ontologies with TOMM20L: view

Phenotypes for TOMM20L Gene

genes like me logo Genes that share phenotypes with TOMM20L: view

Animal Models for TOMM20L Gene

MGI Knock Outs for TOMM20L:
  • Tomm20l Tomm20l<tm1a(EUCOMM)Wtsi>

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TOMM20L Gene

Localization for TOMM20L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM20L Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOMM20L gene
Compartment Confidence
mitochondrion 4
plasma membrane 1
extracellular 1
cytosol 1
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for TOMM20L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0005742 mitochondrial outer membrane translocase complex IEA,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031307 integral component of mitochondrial outer membrane IBA 21873635
genes like me logo Genes that share ontologies with TOMM20L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TOMM20L Gene

Pathways & Interactions for TOMM20L Gene

PathCards logo

SuperPathways for TOMM20L Gene

No Data Available

Interacting Proteins for TOMM20L Gene

;

Gene Ontology (GO) - Biological Process for TOMM20L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0006886 intracellular protein transport IEA --
GO:0016031 tRNA import into mitochondrion IBA 21873635
GO:0030150 protein import into mitochondrial matrix IBA 21873635
GO:0070096 mitochondrial outer membrane translocase complex assembly IBA 21873635
genes like me logo Genes that share ontologies with TOMM20L: view

No data available for Pathways by source and SIGNOR curated interactions for TOMM20L Gene

Drugs & Compounds for TOMM20L Gene

No Compound Related Data Available

Transcripts for TOMM20L Gene

mRNA/cDNA for TOMM20L Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM20L Gene

No ASD Table

Relevant External Links for TOMM20L Gene

GeneLoc Exon Structure for
TOMM20L

Expression for TOMM20L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TOMM20L Gene

mRNA differential expression in normal tissues according to GTEx for TOMM20L Gene

This gene is overexpressed in Testis (x28.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TOMM20L

SOURCE GeneReport for Unigene cluster for TOMM20L Gene:

Hs.592307
genes like me logo Genes that share expression patterns with TOMM20L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOMM20L Gene

Orthologs for TOMM20L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOMM20L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM20L 31 30
  • 99.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TOMM20L 30
  • 87.25 (n)
-- 31
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TOMM20L 31 30
  • 83.77 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm20l 30
  • 74.05 (n)
mouse
(Mus musculus)
Mammalia Tomm20l 17 31 30
  • 71.05 (n)
oppossum
(Monodelphis domestica)
Mammalia TOMM20L 31
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOMM20L 31
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tomboy20 31
  • 26 (a)
ManyToMany
Tom20 31
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tomm-20 31
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM20 33
Species where no ortholog for TOMM20L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TOMM20L Gene

ENSEMBL:
Gene Tree for TOMM20L (if available)
TreeFam:
Gene Tree for TOMM20L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TOMM20L: view image

Paralogs for TOMM20L Gene

Paralogs for TOMM20L Gene

(1) SIMAP similar genes for TOMM20L Gene using alignment to 2 proteins:

  • TO20L_HUMAN
  • G3V4A4_HUMAN
genes like me logo Genes that share paralogs with TOMM20L: view

Variants for TOMM20L Gene

Additional dbSNP identifiers (rs#s) for TOMM20L Gene

Structural Variations from Database of Genomic Variants (DGV) for TOMM20L Gene

Variant ID Type Subtype PubMed ID
esv2748733 CNV deletion 23290073

Variation tolerance for TOMM20L Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TOMM20L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOMM20L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TOMM20L Gene

Disorders for TOMM20L Gene

MalaCards: The human disease database

(1) MalaCards diseases for TOMM20L Gene - From: DISEASES

Disorder Aliases PubMed IDs
mitochondrial complex i deficiency, nuclear type 1
  • mc1dn1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TOMM20L

genes like me logo Genes that share disorders with TOMM20L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOMM20L Gene

Publications for TOMM20L Gene

  1. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. (PMID: 15733919) Likić VA … Lithgow T (Journal of molecular biology 2005) 2 3 54
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  3. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54

Products for TOMM20L Gene

Sources for TOMM20L Gene