Aliases for TOLLIP Gene
External Ids for TOLLIP Gene
Previous GeneCards Identifiers for TOLLIP Gene
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
GeneCards Summary for TOLLIP Gene
TOLLIP (Toll Interacting Protein) is a Protein Coding gene. Diseases associated with TOLLIP include Tick Paralysis and Postinflammatory Pulmonary Fibrosis. Among its related pathways are TRAF Pathway and Toll Comparative Pathway. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and kinase binding.
UniProtKB/Swiss-Prot Summary for TOLLIP Gene
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).