TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004] See more...

Aliases for TOB2 Gene

Aliases for TOB2 Gene

  • Transducer Of ERBB2, 2 2 3 5
  • Transducer Of ErbB-2 2 3 4
  • Protein Tob2 3 4
  • Protein Tob4 3 4
  • TROB2 3 4
  • TOB4 3 4
  • KIAA1663 4
  • APRO5 3
  • TOBL 3

External Ids for TOB2 Gene

Previous HGNC Symbols for TOB2 Gene

  • TROB2

Previous GeneCards Identifiers for TOB2 Gene

  • GC22M038444
  • GC22M040072
  • GC22M040153
  • GC22M041829
  • GC22M024795

Summaries for TOB2 Gene

Entrez Gene Summary for TOB2 Gene

  • TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]

GeneCards Summary for TOB2 Gene

TOB2 (Transducer Of ERBB2, 2) is a Protein Coding gene. Diseases associated with TOB2 include Basilar Artery Insufficiency. Among its related pathways are Signaling by BMP and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include vitamin D receptor binding. An important paralog of this gene is TOB1.

UniProtKB/Swiss-Prot Summary for TOB2 Gene

  • Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.

Gene Wiki entry for TOB2 Gene

Additional gene information for TOB2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TOB2 Gene

Genomics for TOB2 Gene

GeneHancer (GH) Regulatory Elements for TOB2 Gene

Promoters and enhancers for TOB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TOB2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TOB2

Top Transcription factor binding sites by QIAGEN in the TOB2 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • GATA-2
  • NF-YA
  • NF-YB
  • NF-YC

Genomic Locations for TOB2 Gene

Genomic Locations for TOB2 Gene
chr22:41,433,488-41,448,230
(GRCh38/hg38)
Size:
14,743 bases
Orientation:
Minus strand
chr22:41,829,492-41,843,027
(GRCh37/hg19)
Size:
13,536 bases
Orientation:
Minus strand

Genomic View for TOB2 Gene

Genes around TOB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOB2 Gene

Proteins for TOB2 Gene

  • Protein details for TOB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14106-TOB2_HUMAN
    Recommended name:
    Protein Tob2
    Protein Accession:
    Q14106
    Secondary Accessions:
    • Q6FHR7
    • Q6PIT9
    • Q9BY97
    • Q9UBI0

    Protein attributes for TOB2 Gene

    Size:
    344 amino acids
    Molecular mass:
    36632 Da
    Quaternary structure:
    • Associates with CAF1.
    SequenceCaution:
    • Sequence=BAB33333.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TOB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOB2 Gene

Post-translational modifications for TOB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOB2 Gene

No data available for DME Specific Peptides for TOB2 Gene

Domains & Families for TOB2 Gene

Gene Families for TOB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TOB2 Gene

Blocks:
  • Ataxin-2, C-terminal
  • Anti-proliferative protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOB2 Gene

GenScript: Design optimal peptide antigens:
  • TOB2 protein (Q6PIT9_HUMAN)
  • Transducer of erbB-2 2 (TOB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14106

UniProtKB/Swiss-Prot:

TOB2_HUMAN :
  • Belongs to the BTG family.
Family:
  • Belongs to the BTG family.
genes like me logo Genes that share domains with TOB2: view

Function for TOB2 Gene

Molecular function for TOB2 Gene

UniProtKB/Swiss-Prot Function:
Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.

Phenotypes From GWAS Catalog for TOB2 Gene

Gene Ontology (GO) - Molecular Function for TOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IBA 21873635
GO:0005515 protein binding IPI 19838187
GO:0042809 vitamin D receptor binding IEA --
genes like me logo Genes that share ontologies with TOB2: view
genes like me logo Genes that share phenotypes with TOB2: view

Animal Models for TOB2 Gene

MGI Knock Outs for TOB2:

Animal Model Products

CRISPR Products

miRNA for TOB2 Gene

miRTarBase miRNAs that target TOB2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOB2 Gene

Localization for TOB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOB2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOB2 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,TAS 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TOB2: view

Pathways & Interactions for TOB2 Gene

genes like me logo Genes that share pathways with TOB2: view

Pathways by source for TOB2 Gene

1 KEGG pathway for TOB2 Gene

Gene Ontology (GO) - Biological Process for TOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007292 female gamete generation TAS 10602502
GO:0008285 negative regulation of cell proliferation IEA --
GO:0010468 regulation of gene expression IBA,IEA 21873635
GO:0045671 negative regulation of osteoclast differentiation IEA --
GO:0045778 positive regulation of ossification IEA --
genes like me logo Genes that share ontologies with TOB2: view

No data available for SIGNOR curated interactions for TOB2 Gene

Drugs & Compounds for TOB2 Gene

No Compound Related Data Available

Transcripts for TOB2 Gene

mRNA/cDNA for TOB2 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOB2

Alternative Splicing Database (ASD) splice patterns (SP) for TOB2 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for TOB2 Gene

GeneLoc Exon Structure for
TOB2

Expression for TOB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TOB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TOB2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TOB2

SOURCE GeneReport for Unigene cluster for TOB2 Gene:

Hs.474978

mRNA Expression by UniProt/SwissProt for TOB2 Gene:

Q14106-TOB2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TOB2 Gene

  • Nervous system(4.7)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with TOB2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOB2 Gene

Orthologs for TOB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TOB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOB2 30
  • 99.9 (n)
cow
(Bos Taurus)
Mammalia TOB2 31 30
  • 89.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TOB2 31 30
  • 88.96 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tob2 17 31 30
  • 87.89 (n)
rat
(Rattus norvegicus)
Mammalia Tob2 30
  • 87.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TOB2 31
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOB2 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TOB2 31 30
  • 81.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOB2 31
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tob2 30
  • 71.92 (n)
Str.2119 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.12100 30
zebrafish
(Danio rerio)
Actinopterygii tob1b 31
  • 62 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Tob 31 32
  • 25 (a)
OneToMany
Species where no ortholog for TOB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOB2 Gene

ENSEMBL:
Gene Tree for TOB2 (if available)
TreeFam:
Gene Tree for TOB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TOB2: view image

Paralogs for TOB2 Gene

Paralogs for TOB2 Gene

(5) SIMAP similar genes for TOB2 Gene using alignment to 3 proteins:

  • TOB2_HUMAN
  • B0QXZ4_HUMAN
  • Q6PIT9_HUMAN

Pseudogenes.org Pseudogenes for TOB2 Gene

genes like me logo Genes that share paralogs with TOB2: view

Variants for TOB2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TOB2 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
784421 Benign: not provided 41,436,557(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for TOB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TOB2 Gene

Variant ID Type Subtype PubMed ID
nsv459888 CNV gain 19166990
nsv516925 CNV loss 19592680
nsv524585 CNV loss 19592680
nsv589050 CNV gain 21841781
nsv834207 CNV loss 17160897
nsv834208 CNV loss 17160897
nsv962798 CNV duplication 23825009

Variation tolerance for TOB2 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TOB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOB2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOB2 Gene

Disorders for TOB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TOB2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
basilar artery insufficiency
  • basilar artery syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TOB2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TOB2

genes like me logo Genes that share disorders with TOB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOB2 Gene

Publications for TOB2 Gene

  1. Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. (PMID: 10602502) Ikematsu N … Yamamoto T (Oncogene 1999) 2 3 4 23 54
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 54
  5. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 54

Products for TOB2 Gene

Sources for TOB2 Gene