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Aliases for TOB2 Gene

Aliases for TOB2 Gene

  • Transducer Of ERBB2, 2 2 3 5
  • Transducer Of ErbB-2 2 3 4
  • Protein Tob4 3 4
  • TROB2 3 4
  • TOB4 3 4
  • Protein Tob2 3
  • KIAA1663 4
  • APRO5 3
  • TOBL 3

External Ids for TOB2 Gene

Previous HGNC Symbols for TOB2 Gene

  • TROB2

Previous GeneCards Identifiers for TOB2 Gene

  • GC22M038444
  • GC22M040072
  • GC22M040153
  • GC22M041829
  • GC22M024795

Summaries for TOB2 Gene

Entrez Gene Summary for TOB2 Gene

  • TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]

GeneCards Summary for TOB2 Gene

TOB2 (Transducer Of ERBB2, 2) is a Protein Coding gene. Diseases associated with TOB2 include Primary Hypomagnesemia. Among its related pathways are Signaling by BMP and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include vitamin D receptor binding. An important paralog of this gene is TOB1.

UniProtKB/Swiss-Prot for TOB2 Gene

  • Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.

Gene Wiki entry for TOB2 Gene

Additional gene information for TOB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOB2 Gene

Genomics for TOB2 Gene

GeneHancer (GH) Regulatory Elements for TOB2 Gene

Promoters and enhancers for TOB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I041444 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 553.6 +1.5 1514 5.9 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 TOB2 LOC105373043 L3MBTL2 ZC3H7B PHF5A EP300 SLC25A17 POLR3H NDUFA6-AS1 XRCC6
GH22I041467 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 12.3 -22.6 -22600 7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 PHF5A ACO2 POLR3H MEI1 TOB2 EP300 NAGA CSDC2 L3MBTL2 FAM109B
GH22I041090 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.6 +355.4 355364 4.7 HDGF FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 EP300 MIR1281 PHF5A ENSG00000272834 L3MBTL2 XRCC6 LOC100506544 EP300-AS1 ENSG00000232754 ENSG00000227413
GH22I041815 Enhancer 1 ENCODE dbSUPER 13.6 -369.3 -369334 3.9 ZNF493 ZNF529 ZFP64 ZNF121 ZNF213 ZNF354C ZNF138 ZNF680 ZNF654 ZBTB11 EP300 RN7SKP80 PHF5A POLDIP3 ENSG00000232754 RPL5P34 RRP7BP L3MBTL2 XRCC6 DNAJB7
GH22I041409 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +35.3 35254 6.2 HDGF FOXA2 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 GC22P041413 MEI1 EP300 POLR3H PHF5A CYP2D8P TCF20 SLC25A17 NAGA ENSG00000272834
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TOB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TOB2 gene promoter:

Genomic Locations for TOB2 Gene

Genomic Locations for TOB2 Gene
14,743 bases
Minus strand

Genomic View for TOB2 Gene

Genes around TOB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOB2 Gene

Proteins for TOB2 Gene

  • Protein details for TOB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Tob2
    Protein Accession:
    Secondary Accessions:
    • Q6FHR7
    • Q6PIT9
    • Q9BY97
    • Q9UBI0

    Protein attributes for TOB2 Gene

    344 amino acids
    Molecular mass:
    36632 Da
    Quaternary structure:
    • Associates with CAF1.
    • Sequence=BAB33333.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TOB2 Gene


neXtProt entry for TOB2 Gene

Post-translational modifications for TOB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOB2 Gene

No data available for DME Specific Peptides for TOB2 Gene

Domains & Families for TOB2 Gene

Gene Families for TOB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TOB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BTG family.
  • Belongs to the BTG family.
genes like me logo Genes that share domains with TOB2: view

Function for TOB2 Gene

Molecular function for TOB2 Gene

UniProtKB/Swiss-Prot Function:
Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.

Phenotypes From GWAS Catalog for TOB2 Gene

Gene Ontology (GO) - Molecular Function for TOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IBA --
GO:0005515 protein binding IPI 19838187
GO:0042809 vitamin D receptor binding IEA --
genes like me logo Genes that share ontologies with TOB2: view
genes like me logo Genes that share phenotypes with TOB2: view

Animal Models for TOB2 Gene

MGI Knock Outs for TOB2:

Animal Model Products

CRISPR Products

miRNA for TOB2 Gene

miRTarBase miRNAs that target TOB2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOB2 Gene

Localization for TOB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOB2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOB2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10602502
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TOB2: view

Pathways & Interactions for TOB2 Gene

genes like me logo Genes that share pathways with TOB2: view

Pathways by source for TOB2 Gene

1 KEGG pathway for TOB2 Gene

Gene Ontology (GO) - Biological Process for TOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007292 female gamete generation TAS 10602502
GO:0008285 negative regulation of cell proliferation IEA --
GO:0010468 regulation of gene expression IBA,IEA --
GO:0023052 signaling IBA --
GO:0045671 negative regulation of osteoclast differentiation IEA --
genes like me logo Genes that share ontologies with TOB2: view

No data available for SIGNOR curated interactions for TOB2 Gene

Drugs & Compounds for TOB2 Gene

No Compound Related Data Available

Transcripts for TOB2 Gene

Unigene Clusters for TOB2 Gene

Transducer of ERBB2, 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOB2 Gene

ExUns: 1a · 1b ^ 2a · 2b

Relevant External Links for TOB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TOB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TOB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TOB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TOB2 Gene:


SOURCE GeneReport for Unigene cluster for TOB2 Gene:


mRNA Expression by UniProt/SwissProt for TOB2 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TOB2 Gene

  • Nervous system(4.7)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with TOB2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOB2 Gene

Orthologs for TOB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TOB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TOB2 33
  • 99.9 (n)
(Bos Taurus)
Mammalia TOB2 33 34
  • 89.63 (n)
(Canis familiaris)
Mammalia TOB2 33 34
  • 88.96 (n)
(Mus musculus)
Mammalia Tob2 33 16 34
  • 87.89 (n)
(Rattus norvegicus)
Mammalia Tob2 33
  • 87.89 (n)
(Ornithorhynchus anatinus)
Mammalia TOB2 34
  • 85 (a)
(Monodelphis domestica)
Mammalia TOB2 34
  • 75 (a)
(Gallus gallus)
Aves TOB2 33 34
  • 81.24 (n)
(Anolis carolinensis)
Reptilia TOB2 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tob2 33
  • 71.92 (n)
Str.2119 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12100 33
(Danio rerio)
Actinopterygii tob1b 34
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tob 35 34
  • 55 (a)
Species where no ortholog for TOB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOB2 Gene

Gene Tree for TOB2 (if available)
Gene Tree for TOB2 (if available)

Paralogs for TOB2 Gene

Paralogs for TOB2 Gene

(5) SIMAP similar genes for TOB2 Gene using alignment to 3 proteins: Pseudogenes for TOB2 Gene

genes like me logo Genes that share paralogs with TOB2: view

Variants for TOB2 Gene

Sequence variations from dbSNP and Humsavar for TOB2 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000010160 -- 41,435,247(-) C/T 3_prime_UTR_variant
rs1000217440 -- 41,439,446(-) T/C/G intron_variant
rs1000227267 -- 41,445,918(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000253145 -- 41,442,170(-) G/C intron_variant
rs1000305982 -- 41,444,025(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TOB2 Gene

Variant ID Type Subtype PubMed ID
nsv459888 CNV gain 19166990
nsv516925 CNV loss 19592680
nsv524585 CNV loss 19592680
nsv589050 CNV gain 21841781
nsv834207 CNV loss 17160897
nsv834208 CNV loss 17160897
nsv962798 CNV duplication 23825009

Variation tolerance for TOB2 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TOB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOB2 Gene

Disorders for TOB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TOB2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
primary hypomagnesemia
  • hypomagnesemia 1, intestinal
- elite association - COSMIC cancer census association via MalaCards
Search TOB2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TOB2

genes like me logo Genes that share disorders with TOB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOB2 Gene

Publications for TOB2 Gene

  1. Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. (PMID: 10602502) Ikematsu N … Yamamoto T (Oncogene 1999) 2 3 4 22 58
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4 58
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58

Products for TOB2 Gene

Sources for TOB2 Gene

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