Aliases for TOB1 Gene
External Ids for TOB1 Gene
Previous HGNC Symbols for TOB1 Gene
Previous GeneCards Identifiers for TOB1 Gene
This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for TOB1 Gene
TOB1 (Transducer Of ERBB2, 1) is a Protein Coding gene. Diseases associated with TOB1 include Lung Cancer. Among its related pathways are IL-2 Gene Expression in Activated and Quiescent T-Cells and MAPK Signaling: Mitogens. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and SMAD binding. An important paralog of this gene is TOB2.
UniProtKB/Swiss-Prot Summary for TOB1 Gene
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).