This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] See more...

Aliases for TOB1 Gene

Aliases for TOB1 Gene

  • Transducer Of ERBB2, 1 2 3 5
  • TOB 2 3 4
  • Transducer Of ErbB-2 1 3 4
  • Protein Tob1 3 4
  • APRO5 2 3
  • TROB1 3 4
  • TROB 2 3
  • Proliferation-Inducing Gene 49 3
  • APRO6 3
  • PIG49 3
  • TOB1 5

External Ids for TOB1 Gene

Previous HGNC Symbols for TOB1 Gene

  • TROB1

Previous GeneCards Identifiers for TOB1 Gene

  • GC17M048653
  • GC17M051420
  • GC17M049281
  • GC17M049414
  • GC17M046294
  • GC17M048939
  • GC17M044308

Summaries for TOB1 Gene

Entrez Gene Summary for TOB1 Gene

  • This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for TOB1 Gene

TOB1 (Transducer Of ERBB2, 1) is a Protein Coding gene. Diseases associated with TOB1 include Lung Cancer. Among its related pathways are IL-2 Gene Expression in Activated and Quiescent T-Cells and MAPK Signaling: Mitogens. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and SMAD binding. An important paralog of this gene is TOB2.

UniProtKB/Swiss-Prot Summary for TOB1 Gene

  • Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).

Gene Wiki entry for TOB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TOB1 Gene

Genomics for TOB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TOB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TOB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TOB1

Top Transcription factor binding sites by QIAGEN in the TOB1 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • FOXO4
  • Hlf
  • Pax-2

Genomic Locations for TOB1 Gene

Genomic Locations for TOB1 Gene
chr17:50,862,223-50,867,978
(GRCh38/hg38)
Size:
5,756 bases
Orientation:
Minus strand
chr17:48,939,584-48,945,339
(GRCh37/hg19)
Size:
5,756 bases
Orientation:
Minus strand

Genomic View for TOB1 Gene

Genes around TOB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOB1 Gene

Proteins for TOB1 Gene

  • Protein details for TOB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50616-TOB1_HUMAN
    Recommended name:
    Protein Tob1
    Protein Accession:
    P50616
    Secondary Accessions:
    • B2R9T0
    • D3DTY3
    • Q4KMQ0

    Protein attributes for TOB1 Gene

    Size:
    345 amino acids
    Molecular mass:
    38155 Da
    Quaternary structure:
    • Interacts with ERBB2 (PubMed:8632892). Interacts with CNOT7 (PubMed:19276069, PubMed:21336257, PubMed:23236473). Interacts with CPEB3 (via C-terminal RNA-binding region); recruits CNOT7 to CPEB3 to form a ternary complex required for mRNA deadenylation and decay (PubMed:21336257). Interacts with CNOT8 (PubMed:23236473). Interacts with CPEB4 (PubMed:21336257).

    Three dimensional structures from OCA and Proteopedia for TOB1 Gene

neXtProt entry for TOB1 Gene

Post-translational modifications for TOB1 Gene

Other Protein References for TOB1 Gene

No data available for DME Specific Peptides for TOB1 Gene

Domains & Families for TOB1 Gene

Gene Families for TOB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TOB1 Gene

InterPro:
Blocks:
  • Anti-proliferative protein
ProtoNet:

Suggested Antigen Peptide Sequences for TOB1 Gene

GenScript: Design optimal peptide antigens:
  • Transducer of erbB-2 1 (TOB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50616

UniProtKB/Swiss-Prot:

TOB1_HUMAN :
  • Belongs to the BTG family.
Family:
  • Belongs to the BTG family.
genes like me logo Genes that share domains with TOB1: view

Function for TOB1 Gene

Molecular function for TOB1 Gene

UniProtKB/Swiss-Prot Function:
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).

Phenotypes From GWAS Catalog for TOB1 Gene

Gene Ontology (GO) - Molecular Function for TOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IBA 21873635
GO:0005070 SH3/SH2 adaptor activity TAS --
GO:0005515 protein binding IPI 18377426
GO:0030971 receptor tyrosine kinase binding IDA 8632892
GO:0046332 SMAD binding IEA --
genes like me logo Genes that share ontologies with TOB1: view
genes like me logo Genes that share phenotypes with TOB1: view

Animal Models for TOB1 Gene

MGI Knock Outs for TOB1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOB1 Gene

Localization for TOB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOB1 Gene

Cytoplasm. Nucleus. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOB1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
mitochondrion 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0030014 CCR4-NOT complex IDA 21336257
genes like me logo Genes that share ontologies with TOB1: view

Pathways & Interactions for TOB1 Gene

PathCards logo

SuperPathways for TOB1 Gene

SuperPathway Contained pathways
1 IL-2 Gene Expression in Activated and Quiescent T-Cells
.40
.40
2 Deadenylation-dependent mRNA decay
3 MAPK Signaling: Mitogens
4 nNOS Signaling in Skeletal Muscle
.01
5 Immune response IL-2 activation and signaling pathway
.41
genes like me logo Genes that share pathways with TOB1: view

Pathways by source for TOB1 Gene

1 KEGG pathway for TOB1 Gene
1 GeneGo (Thomson Reuters) pathway for TOB1 Gene
  • Immune response IL-2 activation and signaling pathway
1 R&D Systems pathway for TOB1 Gene
3 Qiagen pathways for TOB1 Gene
  • IL-2 Gene Expression in Activated and Quiescent T-Cells
  • TOB in Osteoblast Signaling
  • TOB in T-Cell Signaling

SIGNOR curated interactions for TOB1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS,IDA 8632892
GO:0009967 positive regulation of signal transduction IEA --
GO:0010468 regulation of gene expression IBA 21873635
GO:0017148 negative regulation of translation IDA 23236473
GO:0030514 negative regulation of BMP signaling pathway IEA --
genes like me logo Genes that share ontologies with TOB1: view

Drugs & Compounds for TOB1 Gene

(3) Drugs for TOB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TOB1: view

Transcripts for TOB1 Gene

mRNA/cDNA for TOB1 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOB1

Alternative Splicing Database (ASD) splice patterns (SP) for TOB1 Gene

No ASD Table

Relevant External Links for TOB1 Gene

GeneLoc Exon Structure for
TOB1

Expression for TOB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TOB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TOB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TOB1 Gene



Protein tissue co-expression partners for TOB1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TOB1

SOURCE GeneReport for Unigene cluster for TOB1 Gene:

Hs.703321

mRNA Expression by UniProt/SwissProt for TOB1 Gene:

P50616-TOB1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TOB1 Gene

  • Nervous system(4.8)
  • Muscle(3.7)
  • Liver(3.6)
  • Kidney(3.3)
  • Stomach(3.2)
  • Heart(3.2)
  • Intestine(2.9)
  • Blood(2.6)
  • Lung(2.4)
  • Thyroid gland(2.3)
  • Skin(2.3)
  • Pancreas(2.1)
  • Bone marrow(2.1)
  • Adrenal gland(2.1)
  • Lymph node(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with TOB1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOB1 Gene

Orthologs for TOB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TOB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TOB1 30 31
  • 99.81 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TOB1 30 31
  • 97.49 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TOB1 30 31
  • 96.68 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TOB1 31
  • 94 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TOB1 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Tob1 30 17 31
  • 91.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tob1 30
  • 90.34 (n)
Chicken
(Gallus gallus)
Aves TOB 31
  • 98 (a)
OneToOne
TOB1 30
  • 90.77 (n)
Lizard
(Anolis carolinensis)
Reptilia TOB1 31
  • 94 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tob1 30
  • 73.01 (n)
Str.11008 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68457 30
Zebrafish
(Danio rerio)
Actinopterygii tob1a 30 31
  • 76.7 (n)
OneToOne
tob1 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8983 30
Fruit Fly
(Drosophila melanogaster)
Insecta Tob 31 32
  • 26 (a)
OneToMany
Species where no ortholog for TOB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TOB1 Gene

ENSEMBL:
Gene Tree for TOB1 (if available)
TreeFam:
Gene Tree for TOB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TOB1: view image

Paralogs for TOB1 Gene

Paralogs for TOB1 Gene

(3) SIMAP similar genes for TOB1 Gene using alignment to 1 proteins:

  • TOB1_HUMAN
genes like me logo Genes that share paralogs with TOB1: view

Variants for TOB1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TOB1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs3316 - p.Lys319Arg

Additional dbSNP identifiers (rs#s) for TOB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TOB1 Gene

Variant ID Type Subtype PubMed ID
nsv1112713 CNV deletion 24896259

Variation tolerance for TOB1 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TOB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOB1 Gene

Disorders for TOB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TOB1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards
Search TOB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TOB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TOB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOB1 Gene

Publications for TOB1 Gene

  1. Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity. (PMID: 8632892) Matsuda S … Yamamoto T (Oncogene 1996) 2 3 4 23
  2. Structural basis for the antiproliferative activity of the Tob-hCaf1 complex. (PMID: 19276069) Horiuchi M … Inagaki F (The Journal of biological chemistry 2009) 3 4 23
  3. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. (PMID: 23236473) Doidge R … Winkler GS (PloS one 2012) 3 4
  4. Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase. (PMID: 21336257) Hosoda N … Hoshino S (The EMBO journal 2011) 3 4
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 41

Products for TOB1 Gene

  • Signalway ELISA kits for TOB1

Sources for TOB1 Gene