TNS2 Gene (Protein Coding)

Tensin 2

GC12P053046
GIFtS:
35
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 200... See more...

Aliases for TNS2 Gene

Aliases for TNS2 Gene

  • Tensin 2 2 3 5
  • C1-TEN 2 3 4
  • Tensin Like C1 Domain Containing Phosphatase (Tensin 2) 2 3
  • C1 Domain-Containing Phosphatase And Tensin Homolog 3 4
  • Tensin-Like C1 Domain-Containing Phosphatase 3 4
  • Tensin-2 3 4
  • KIAA1075 2 4
  • TENC1 3 4
  • Tensin Like C1 Domain-Containing Phosphatase 2
  • EC 3.1.3.48 4
  • C1TEN 3
  • TNS2 5

External Ids for TNS2 Gene

Previous HGNC Symbols for TNS2 Gene

  • TENC1

Summaries for TNS2 Gene

Entrez Gene Summary for TNS2 Gene

  • The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNS2 Gene

TNS2 (Tensin 2) is a Protein Coding gene. Diseases associated with TNS2 include Endocardial Fibroelastosis. Among its related pathways are Adhesion and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include kinase binding and phosphoprotein phosphatase activity. An important paralog of this gene is TNS4.

UniProtKB/Swiss-Prot Summary for TNS2 Gene

  • Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856).

Gene Wiki entry for TNS2 Gene

Additional gene information for TNS2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNS2 Gene

Genomics for TNS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TNS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J053043 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 268.6 +2.6 2644 12 CHD2 TBP ZBTB10 MXD4 CEBPA MNT DEK IKZF1 SMAD5 ZNF217 TNS2 LOC283335 EIF4B AAAS ZNF740 TARBP2 MAP3K12 NPFF MYG1-AS1 CSAD
GH12J053215 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.9 +174.0 174039 10.4 ZSCAN16 SP1 BCL11A ZBTB10 CEBPA MNT DEK IKZF1 SMAD5 ETS1 RARG lnc-ITGB7-3 ITGB7 MAP3K12 TNS2 SP1 IGFBP6 PFDN5 MYG1 TARBP2
GH12J053060 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.8 +20.0 19960 13.5 ZBTB10 CEBPA FOXA1 DEK IKZF1 ZNF217 CTCF ZBTB7B ELF1 ZIC2 HSALNG0091234 piR-57133-115 PFDN5 AAAS ZNF740 ATF7 PCBP2 SP1 LOC283335 LOC100652999
GH12J052991 Enhancer 1.1 ENCODE dbSUPER 8.8 -54.3 -54251 2.6 MXD4 CEBPA MNT IKZF1 ZNF395 REST FOXA2 SMAD4 MAFF SAP130 piR-61945-100 EIF4B KRT18 TNS2 SPRYD3 lnc-KRT8-3 KRT8
GH12J052974 Enhancer 1.2 ENCODE CraniofacialAtlas dbSUPER 4.6 -70.9 -70850 3.5 ZNF217 DEK IKZF1 CTCF ZBTB7B REST MBD2 CUX1 MAX SMAD4 EIF4B AAAS KRT18 ZNF740 TARBP2 KRT82 KRT71 ENSG00000257808 CSAD KRT84
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNS2

Genomic Locations for TNS2 Gene

Latest Assembly
chr12:53,046,969-53,064,379
(GRCh38/hg38)
Size:
17,411 bases
Orientation:
Plus strand

Previous Assembly
chr12:53,440,775-53,458,163
(GRCh37/hg19 by Entrez Gene)
Size:
17,389 bases
Orientation:
Plus strand

chr12:53,440,753-53,458,156
(GRCh37/hg19 by Ensembl)
Size:
17,404 bases
Orientation:
Plus strand

Genomic View for TNS2 Gene

Genes around TNS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNS2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TNS2 Gene

Proteins for TNS2 Gene

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  • Protein details for TNS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HR2-TNS2_HUMAN
    Recommended name:
    Tensin-2
    Protein Accession:
    Q63HR2
    Secondary Accessions:
    • A2VDF2
    • A2VDF3
    • A2VDI8
    • A5PKY4
    • Q2NL80
    • Q76MW6
    • Q7Z5T9
    • Q8NFF9
    • Q8NFG0
    • Q96P25
    • Q9NT29
    • Q9UPS7

    Protein attributes for TNS2 Gene

    Size:
    1409 amino acids
    Molecular mass:
    152580 Da
    Quaternary structure:
    • Interacts with AXL. Interacts with SYK; leading to its phosphorylation (PubMed:22019427).
    SequenceCaution:
    • Sequence=AAI29829.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI29830.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI31504.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA83027.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAH56176.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNS2 Gene

    Alternative splice isoforms for TNS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNS2 Gene

Protein Expression for TNS2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TNS2 Gene

  • Glycosylation at Asn445
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for TNS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNS2 Gene

Domains & Families for TNS2 Gene

Gene Families for TNS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TNS2 Gene

InterPro:
Blocks:
  • SH2 domain signature
  • Tensin phosphotyrosine-binding domain
ProtoNet:

Suggested Antigen Peptide Sequences for TNS2 Gene

GenScript: Design optimal peptide antigens:
  • Tensin like C1 domain containing phosphatase (Tensin 2) (A7E2A6_HUMAN)
  • cDNA FLJ16320 fis, clone SPLEN2036702, highly similar to Homo sapiens tensin like C1 domain containing phosphatase (tensin 2) (TENC1), transcript variant 2, mRNA (B3KYA3_HUMAN)
  • Tensin-2 (TENC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q63HR2

UniProtKB/Swiss-Prot:

TNS2_HUMAN :
  • Belongs to the PTEN phosphatase protein family.
Family:
  • Belongs to the PTEN phosphatase protein family.
genes like me logo Genes that share domains with TNS2: view

Function for TNS2 Gene

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  6. Cell Lines for research

Molecular function for TNS2 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000269|PubMed:23401856};.

Enzyme Numbers (IUBMB) for TNS2 Gene

Phenotypes From GWAS Catalog for TNS2 Gene

Gene Ontology (GO) - Molecular Function for TNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,IDA 23401856
GO:0005515 protein binding IEA,IPI 16273093
GO:0016787 hydrolase activity IEA --
GO:0019900 kinase binding IPI 22019427
genes like me logo Genes that share ontologies with TNS2: view
genes like me logo Genes that share phenotypes with TNS2: view

miRNA for TNS2 Gene

miRTarBase miRNAs that target TNS2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNS2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNS2 Gene

Localization for TNS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNS2 Gene

Cell junction, focal adhesion. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Note=Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies (PubMed:22019427). {ECO:0000269 PubMed:22019427}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNS2 gene
Compartment Confidence
plasma membrane 4
nucleus 3
extracellular 2
cytoskeleton 2
cytosol 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IEA,IDA 16951145
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with TNS2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNS2 Gene

Pathways & Interactions for TNS2 Gene

PathCards logo

SuperPathways for TNS2 Gene

genes like me logo Genes that share pathways with TNS2: view

Pathways by source for TNS2 Gene

3 Cell Signaling Technology pathways for TNS2 Gene

Gene Ontology (GO) - Biological Process for TNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0008285 negative regulation of cell proliferation IMP 16951145
GO:0014850 response to muscle activity IEA --
GO:0019725 cellular homeostasis IEA --
GO:0032963 collagen metabolic process IEA --
genes like me logo Genes that share ontologies with TNS2: view

No data available for SIGNOR curated interactions for TNS2 Gene

Drugs & Compounds for TNS2 Gene

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(5) Additional Compounds for TNS2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
 257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
 91125-76-7, 29541-66-0, 51621-26-2
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with TNS2: view

Transcripts for TNS2 Gene

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mRNA/cDNA for TNS2 Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNS2

Alternative Splicing Database (ASD) splice patterns (SP) for TNS2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - - -
SP7:
SP8:
SP9: -
SP10:
SP11: -
SP12:
SP13:
SP14: - - -

ExUns: 18b ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - -
SP6:
SP7: -
SP8: - -
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for TNS2 Gene

GeneLoc Exon Structure for
TNS2

Expression for TNS2 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNS2 Gene

mRNA expression in normal human tissues for TNS2 Gene
mRNA expression by GTEx for TNS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNS2 Gene

This gene is overexpressed in Adipocyte (39.0) and Gallbladder (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNS2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNS2

mRNA Expression by UniProt/SwissProt for TNS2 Gene:

Q63HR2-TNS2_HUMAN
Tissue specificity: Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.

Evidence on tissue expression from TISSUES for TNS2 Gene

  • Nervous system(4.7)
  • Kidney(4.5)
  • Liver(4.5)
  • Intestine(4.4)
  • Muscle(2.4)
  • Heart(2.3)
  • Pancreas(2.3)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with TNS2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNS2 Gene

Orthologs for TNS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TENC1 30 31
  • 99.53 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TENC1 30 31
  • 89.24 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Tenc1 30
  • 86.32 (n)
Dog
(Canis familiaris)
 Mammalia TENC1 30 31
  • 86.3 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Tenc1 30 31
  • 86.28 (n)
 OneToOne
Tns2 17
Lizard
(Anolis carolinensis)
 Reptilia TENC1 31
  • 50 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia tenc1 30
  • 60.15 (n)
Zebrafish
(Danio rerio)
 Actinopterygii tenc1a 30 31
  • 60.96 (n)
 OneToMany
tenc1b 31
  • 40 (a)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta by 31
  • 29 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea tag-163 31
  • 24 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 25 (a)
 OneToMany
Species where no ortholog for TNS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TNS2 Gene

ENSEMBL:
Gene Tree for TNS2 (if available)
TreeFam:
Gene Tree for TNS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNS2: view image

Paralogs for TNS2 Gene

Paralogs for TNS2 Gene

genes like me logo Genes that share paralogs with TNS2: view

Variants for TNS2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNS2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs113829803 Benign: not provided 53,051,920(+) A/G
NM_170754.4(TNS2):c.141A>G (p.Ala47=) 		SYNONYMOUS_VARIANT,FIVE_PRIME_UTR
rs115643230 Benign: not provided 53,060,052(+) G/A
NM_170754.4(TNS2):c.2411G>A (p.Arg804His) 		MISSENSE
rs117928258 Benign: not provided 53,063,801(+) C/T
NM_170754.4(TNS2):c.4149C>T (p.Leu1383=) 		SYNONYMOUS
rs139881378 Uncertain Significance: not provided 53,061,154(+) G/A
NM_170754.4(TNS2):c.3248G>A (p.Gly1083Glu) 		MISSENSE
rs141470860 Benign: not provided 53,054,330(+) G/A
NM_170754.4(TNS2):c.411G>A (p.Thr137=) 		NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TNS2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TNS2 Gene

Variant ID Type Subtype PubMed ID
dgv2644n54 CNV loss 21841781
esv28917 CNV loss 19812545
nsv1136150 CNV deletion 24896259
nsv470294 CNV loss 18288195
nsv517066 CNV loss 19592680
nsv558985 CNV loss 21841781
nsv558986 CNV loss 21841781

Variation tolerance for TNS2 Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.04; 90.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNS2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNS2 Gene

Disorders for TNS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNS2 Gene - From: COP

Disorder Aliases PubMed IDs
endocardial fibroelastosis
  • efe
- elite association - COSMIC cancer census association via MalaCards
Search TNS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TNS2

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TNS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNS2 Gene

Publications for TNS2 Gene

  1. C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy. (PMID: 23401856) Koh A … Ryu SH (Molecular and cellular biology 2013) 3 4
  2. The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2. (PMID: 22019427) Moon KD … Geahlen RL (Biochimica et biophysica acta 2012) 3 4
  3. Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1. (PMID: 20069572) Clark K … Critchley DR (Journal of cellular biochemistry 2010) 3 23
  4. C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration. (PMID: 15817639) Hafizi S … Dahlbäck B (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005) 3 4
  5. Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. (PMID: 12470648) Hafizi S … Dahlbäck B (Biochemical and biophysical research communications 2002) 3 4

ExternalLinks

View latest publications for TNS2 gene in Mastermind

Products for TNS2 Gene