Aliases for TNS2 Gene
External Ids for TNS2 Gene
Previous HGNC Symbols for TNS2 Gene
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNS2 Gene
TNS2 (Tensin 2) is a Protein Coding gene. Diseases associated with TNS2 include Endocardial Fibroelastosis. Among its related pathways are Cytoskeletal Signaling and Adhesion. Gene Ontology (GO) annotations related to this gene include kinase binding and phosphoprotein phosphatase activity. An important paralog of this gene is TNS4.
UniProtKB/Swiss-Prot Summary for TNS2 Gene
Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856).