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The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multipl... See more...
Aliases for TNS1 Gene
Aliases for TNS1 Gene
External Ids for TNS1 Gene
- HGNC: 11973
- NCBI Entrez Gene: 7145
- Ensembl: ENSG00000079308
- OMIM®: 600076
- UniProtKB/Swiss-Prot: Q9HBL0
Previous HGNC Symbols for TNS1 Gene
- TNS
- MXRA6
Previous GeneCards Identifiers for TNS1 Gene
- GC02M218492
- GC02M218375
- GC02M218664
- GC02M210519
Summaries for TNS1 Gene
-
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
GeneCards Summary for TNS1 Gene
TNS1 (Tensin 1) is a Protein Coding gene. Diseases associated with TNS1 include Cowden Syndrome 1 and Proteus Syndrome. Among its related pathways are Integrin Pathway and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is TNS3.
UniProtKB/Swiss-Prot Summary for TNS1 Gene
-
Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.
Additional gene information for TNS1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNS1 Gene
Genomics for TNS1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TNS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TNS1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNS1
- Top Transcription factor binding sites by QIAGEN in the TNS1 gene promoter:
-
- AP-1
- ATF-2
- c-Fos
- c-Jun
- Hlf
- LUN-1
Genomic Locations for TNS1 Gene
Latest Assembly
- chr2:217,799,588-218,033,982
- (GRCh38/hg38)
- Size:
- 234,395 bases
- Orientation:
- Minus strand
Previous Assembly
- chr2:218,664,514-218,867,718
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 203,205 bases
- Orientation:
- Minus strand
Genomic View for TNS1 Gene
Genes around TNS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q35 by HGNC
- 2q35 by Entrez Gene
- 2q35 by Ensembl
TNS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNS1 Gene
Proteins for TNS1 Gene
-
Protein details for TNS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HBL0-TENS1_HUMAN
- Recommended name:
- Tensin-1
- Protein Accession:
- Q9HBL0
- Q4ZG71
- Q6IPI5
Protein attributes for TNS1 Gene
- Size:
- 1735 amino acids
- Molecular mass:
- 185701 Da
- Quaternary structure:
-
- Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8.
Protein Expression for TNS1 Gene
Post-translational modifications for TNS1 Gene
- Rapidly cleaved by calpain II.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TNS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_016860300.1
- XP_016860301.1
- XP_016860302.1
- XP_016860303.1
- XP_016860304.1
- XP_016860305.1
- XP_024308836.1
- XP_024308837.1
- XP_024308838.1
- XP_024308839.1
- XP_024308840.1
- XP_024308841.1
- XP_024308842.1
- XP_024308843.1
- XP_024308844.1
- XP_024308845.1
- XP_024308846.1
- XP_024308847.1
- XP_024308848.1
- XP_024308849.1
- XP_024308850.1
- XP_024308852.1
- NP_001294951.1
- NP_001294952.1
- NP_001374706.1
- NP_072174.3
Antibodies for research
- Novus Biologicals Antibodies for TNS1
-
Abcam antibodies for TNS1
- Invitrogen Antibodies for TNS1 (AFLGC-TNS1)
-
Boster Bio Antibodies for TNS1
-
Custom Antibody ServicesProSci Antibodies for TNS1
Protein products for research
-
OriGene Purified Proteins for TNS1
- Search Origene for MassSpec and Protein Over-expression Lysates for TNS1
- Origene Custom Protein Services for TNS1
- antibodies-online: Show 3 available Tensin 1 Proteins ranked by validation data
- Compare Top Tensin 1 Proteins
-
Quality Products:
-
Abcam proteins for TNS1
Assay products for research
- antibodies-online: Show 2 available Tensin 1 Elisa Kits ranked by validation data
- Compare Top Tensin 1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TNS1 Gene
Domains & Families for TNS1 Gene
Gene Families for TNS1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TNS1 Gene
- InterPro:
- Blocks:
-
- SH2 domain signature
- Subtilisin serine protease family (S8) signature
- Tensin phosphotyrosine-binding domain
Suggested Antigen Peptide Sequences for TNS1 Gene
- GenScript: Design optimal peptide antigens:
-
- TNS1 protein (A1L0S7_HUMAN)
- Tensin 1, isoform CRA_b (B2RU35_HUMAN)
- MSTP091 (E2PSI9_HUMAN)
- TNS1 protein (Q0VG54_HUMAN)
- TNS1 protein (Q0VG55_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9HBL0- Family:
-
- Belongs to the PTEN phosphatase protein family.
Function for TNS1 Gene
Molecular function for TNS1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.
Phenotypes From GWAS Catalog for TNS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 17190795 |
Phenotypes for TNS1 Gene
- MGI mutant phenotypes for TNS1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TNS1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Large nuclei
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased vaccinia virus (VACV) infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Downregulation of Wnt pathway after Wnt3A stimulation
- Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased cell migration
- Decreased replication of vaccinia virus (VACV)
- Decreased HPV16-GFP infection
- Increased mitotic index
Animal Models for TNS1 Gene
- MGI Knock Outs for TNS1:
-
- Tns1 Tns1<tm1Efu>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TNS1 - Starting at $85 >
- * TNS1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TNS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNS1
miRNA for TNS1 Gene
- miRTarBase miRNAs that target TNS1
-
- mmu-miR-362-5p (MIRT008837)
- hsa-miR-335-5p (MIRT019227)
- hsa-miR-98-5p (MIRT027785)
- mmu-miR-5102 (MIRT594156)
- mmu-miR-1199-5p (MIRT594157)
- mmu-miR-709 (MIRT594158)
- mmu-miR-21a-5p (MIRT594586)
- mmu-miR-590-5p (MIRT594587)
- mmu-miR-466i-3p (MIRT600273)
- mmu-miR-329-3p (MIRT600274)
- mmu-miR-362-3p (MIRT600275)
- hsa-miR-4446-5p (MIRT607351)
- hsa-miR-6809-3p (MIRT607352)
- hsa-miR-6833-3p (MIRT607353)
- hsa-miR-4768-5p (MIRT607354)
- hsa-miR-4753-3p (MIRT607355)
- hsa-miR-6873-3p (MIRT607356)
- hsa-miR-4279 (MIRT607357)
- hsa-miR-6792-3p (MIRT607358)
- hsa-miR-4691-5p (MIRT607359)
- hsa-miR-627-3p (MIRT607360)
- hsa-miR-130b-5p (MIRT607361)
- hsa-miR-6817-3p (MIRT607362)
- hsa-miR-7110-3p (MIRT607363)
- hsa-miR-3679-3p (MIRT612263)
- hsa-miR-4659b-3p (MIRT634189)
- hsa-miR-4659a-3p (MIRT634190)
- hsa-miR-22-5p (MIRT634191)
- hsa-miR-6887-3p (MIRT634192)
- hsa-miR-3691-3p (MIRT634193)
- hsa-miR-5584-3p (MIRT634194)
- hsa-miR-148a-5p (MIRT634195)
- hsa-miR-942-5p (MIRT650904)
- hsa-miR-6783-5p (MIRT650905)
- hsa-miR-8055 (MIRT724965)
- hsa-miR-6739-3p (MIRT724966)
- hsa-miR-375 (MIRT724967)
- hsa-miR-1304-5p (MIRT724968)
- hsa-miR-6858-5p (MIRT724969)
- hsa-miR-4689 (MIRT724970)
- hsa-miR-1224-5p (MIRT724971)
- hsa-miR-3915 (MIRT724972)
- hsa-miR-6868-3p (MIRT724973)
- hsa-miR-8068 (MIRT724974)
- hsa-miR-4326 (MIRT724975)
- hsa-miR-5087 (MIRT724976)
- hsa-miR-4751 (MIRT724977)
- hsa-miR-5004-5p (MIRT724978)
- hsa-miR-1248 (MIRT724979)
- hsa-miR-1237-3p (MIRT724980)
- hsa-miR-4748 (MIRT724981)
- hsa-miR-4464 (MIRT724982)
- hsa-miR-548j-5p (MIRT732174)
- hsa-miR-142-5p (MIRT762652)
- hsa-miR-33a-5p (MIRT765696)
- hsa-miR-33b-5p (MIRT765705)
- hsa-miR-340-5p (MIRT765747)
- hsa-miR-4666a-3p (MIRT770828)
- hsa-miR-4729 (MIRT771772)
- hsa-miR-5590-3p (MIRT774869)
- hsa-miR-5700 (MIRT775203)
- hsa-miR-586 (MIRT775342)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNS1
- Browse OriGene Inhibitory RNA Products For TNS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNS1
Clone products for research
- Applied Biological Materials (abm): Clones for TNS1 - Starting at $45 >
- * TNS1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TNS1
- Addgene plasmids for TNS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNS1
Cell Lines for research
-
Horizon Cell Lines for TNS1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNS1 Gene
Localization for TNS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNS1 Gene
- Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 4 |
| nucleus | 4 |
| plasma membrane | 3 |
| cytosol | 3 |
| extracellular | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Focal adhesion sites (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005925 | focal adhesion | IDA | 11023826 |
| GO:0009986 | cell surface | IEA | -- |
| GO:0030054 | cell junction | IEA | -- |
Pathways & Interactions for TNS1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Integrin Pathway |
FAK1 Signaling
.67
|
|
| 2 | Focal Adhesion | ||
Pathways by source for TNS1 Gene
1 BioSystems pathway for TNS1 Gene
1 Qiagen pathway for TNS1 Gene
- FAK1 Signaling
Interacting Proteins for TNS1 Gene
Selected Interacting proteins:
Q9HBL0-TENS1_HUMAN
ENSP00000171887
for TNS1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TNS1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007044 | cell-substrate junction assembly | IEA | -- |
| GO:0010761 | fibroblast migration | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
No data available for SIGNOR curated interactions for TNS1 Gene
Transcripts for TNS1 Gene
mRNA/cDNA for TNS1 Gene
- 4 REFSEQ mRNAs :
- 24 NCBI additional mRNA sequence :
- 24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000171887 10331 nts (view in UCSC)
- ENST00000310858 1792 nts (view in UCSC)
- ENST00000413280 667 nts (view in UCSC)
- ENST00000413554 1478 nts (view in UCSC)
- ENST00000419504 5921 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TNS1 - Starting at $85 >
- * TNS1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TNS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNS1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNS1
- Browse OriGene Inhibitory RNA Products For TNS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNS1
Clone products for research
- Applied Biological Materials (abm): Clones for TNS1 - Starting at $45 >
- * TNS1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TNS1
- Addgene plasmids for TNS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNS1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||
| SP13: |
Relevant External Links for TNS1 Gene
- GeneLoc Exon Structure for
- TNS1
Expression for TNS1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Basal Cells Trachea
- Duct Cells Pancreatic Ducts
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Outflow Tract
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Kidney (Urinary System)
- Juxtaglomerular Cells Afferent Arteriole
-
Smooth Muscle (Muscoskeletal System)
- Juxtaglomerular Cells Afferent Arteriole
-
Blood (Hematopoietic System)
- Erythroblasts Hematopoietic Bone Marrow
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
- Dermis (Integumentary System)
- Fibroblasts
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for TNS1 Gene
This gene is overexpressed in Artery - Tibial (x5.8) and Artery - Aorta (x4.5).
This gene is overexpressed in Urinary Bladder (12.2), Prostate (8.2), and Gallbladder (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNS1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNS1
SOURCE GeneReport for Unigene cluster for TNS1 Gene:
Hs.471381mRNA Expression by UniProt/SwissProt for TNS1 Gene:
Q9HBL0-TENS1_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for TNS1 Gene
- Heart(4.7)
- Blood(4.6)
- Liver(4.6)
- Skin(4.5)
- Nervous system(3.7)
- Lung(3.6)
- Muscle(3.5)
- Kidney(3.5)
- Intestine(3.4)
- Stomach(3)
- Pancreas(2.9)
- Adrenal gland(2.8)
- Spleen(2.7)
- Thyroid gland(2.7)
- Eye(2.5)
- Bone marrow(2.4)
- Lymph node(2.4)
- Gall bladder(2.1)
Primer products for research
-
OriGene qPCR primer pairs for TNS1
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNS1 Gene
Orthologs for TNS1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TNS1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TNS1 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TNS1 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tns1 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tns1 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TNS1 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TNS1 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TNS1 29 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | TNS1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tns1 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tns1 29 30 |
|
OneToMany | |
| TNS1 (2 of 2) 30 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | by 30 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | tag-163 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2758 29 |
|
- Species where no ortholog for TNS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TNS1 Gene
- ENSEMBL:
- Gene Tree for TNS1 (if available)
- TreeFam:
- Gene Tree for TNS1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TNS1: view image
- Alliance of Genome Resources:
- Additional Orthologs for TNS1
Paralogs for TNS1 Gene
(7) SIMAP similar genes for TNS1 Gene using alignment to 18 proteins:
- TENS1_HUMAN
- A1L0S7_HUMAN
- B2RU35_HUMAN
- C9J8K5_HUMAN
- C9JFT7_HUMAN
- C9JI43_HUMAN
- C9JZT0_HUMAN
- E7EMG1_HUMAN
- E7ERH1_HUMAN
- E9PF55_HUMAN
- E9PGF5_HUMAN
- H7C3Z4_HUMAN
- Q0VG54_HUMAN
- Q0VG55_HUMAN
- Q59G71_HUMAN
- Q6IPI5_HUMAN
- Q6PJM3_HUMAN
- Q86VB0_HUMAN
Variants for TNS1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNS1 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs113181713 | Benign: not provided | 217,897,950(-) |
T/C NM_022648.6(TNS1):c.16A>G (p.Thr6Ala) |
MISSENSE | |
| rs140195511 | Benign: not provided | 217,818,200(-) |
G/T NM_022648.6(TNS1):c.3820C>A (p.Arg1274=) |
SYNONYMOUS | |
| rs141901890 | Likely Benign: not provided | 217,847,726(-) |
T/G NM_022648.6(TNS1):c.2416A>C (p.Asn806His) |
MISSENSE | |
| rs143053944 | Benign: not provided | 217,849,049(-) |
G/C NM_022648.6(TNS1):c.1093C>G (p.Leu365Val) |
MISSENSE | |
| rs143531869 | Benign: not provided | 217,817,897(-) |
C/T NM_022648.6(TNS1):c.4123G>A (p.Ala1375Thr) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4174n100 | CNV | gain | 25217958 |
| dgv4175n100 | CNV | gain | 25217958 |
| esv1006594 | CNV | deletion | 20482838 |
| esv2229410 | CNV | deletion | 18987734 |
| esv2495817 | CNV | insertion | 19546169 |
| esv2664314 | CNV | deletion | 23128226 |
| esv2670055 | CNV | deletion | 23128226 |
| esv2721471 | CNV | deletion | 23290073 |
| esv2760585 | CNV | gain | 21179565 |
| esv3594325 | CNV | gain | 21293372 |
| esv3594326 | CNV | loss | 21293372 |
| nsv460102 | CNV | loss | 19166990 |
| nsv460103 | CNV | loss | 19166990 |
| nsv470517 | CNV | loss | 18288195 |
| nsv475517 | CNV | novel sequence insertion | 20440878 |
| nsv527822 | CNV | loss | 19592680 |
| nsv528835 | CNV | loss | 19592680 |
| nsv584486 | CNV | loss | 21841781 |
| nsv584487 | CNV | loss | 21841781 |
| nsv834541 | CNV | loss | 17160897 |
| nsv954834 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
19.41;
98.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TNS1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNS1 Gene
Disorders for TNS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cowden syndrome 1 |
|
|
| proteus syndrome |
|
|
| mucocele of salivary gland |
|
|
| skin lipoma |
|
|
| penile disease |
|
|
Search TNS1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TNS1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TNS1 Gene
Publications for TNS1 Gene
- Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PMID: 16953426) Beaty TH … Scott AF (Human genetics 2006) 3 22 40
- Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A … Haiman CA (PLoS genetics 2011) 3 40
- Genome-wide association study identifies five loci associated with lung function. (PMID: 20010834) Repapi E … Tobin MD (Nature genetics 2010) 3 40
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 40
- Molecular characterization of human tensin. (PMID: 11023826) Chen H … Lo SH (The Biochemical journal 2000) 3 4
ExternalLinks
Products for TNS1 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TNS1
- Search Origene for MassSpec and Protein Over-expression Lysates for TNS1
- Origene Custom Protein Services for TNS1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNS1
- Browse OriGene Inhibitory RNA Products For TNS1
- OriGene qPCR primer pairs for TNS1
- OriGene CRISPR knockouts for TNS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TNS1
- Sino Biological Human cDNA Clone for TNS1
- Browse Sino Biological Recombinant Proteins
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- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TNS1
- Novus Biologicals proteins and lysates for TNS1
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for TNS1
- Abcam proteins for TNS1
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- Browse Primary Antibodies
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- Invitrogen Antibodies for TNS1 (AFLGC-TNS1)
- VectorBuilder Custom and pre-made DNA vectors for TNS1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TNS1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TNS1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TNS1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TNS1
- Addgene plasmids for TNS1
- antibodies-online: Show 12 available Tensin 1 Antibodies ranked by validation data
- Compare Top Tensin 1 Antibodies
- antibodies-online: Show 2 available Tensin 1 Elisa Kits ranked by validation data
- Compare Top Tensin 1 Elisa Kits
- Quality Products:
- antibodies-online: Show 3 available Tensin 1 Proteins ranked by validation data
- Compare Top Tensin 1 Proteins
- Quality Products:
- Custom Antibody ServicesProSci Antibodies for TNS1
- Search for TNS1 Proteins at ProSci
- Horizon Cell Lines for TNS1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNS1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TNS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNS1
- Boster Bio Antibodies for TNS1
- Browse Boster Bio ELISA Kits
Sources for TNS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources