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The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multipl... See more...
Aliases for TNS1 Gene
Aliases for TNS1 Gene
External Ids for TNS1 Gene
- HGNC: 11973
- Entrez Gene: 7145
- Ensembl: ENSG00000079308
- OMIM: 600076
- UniProtKB: Q9HBL0
Previous HGNC Symbols for TNS1 Gene
- TNS
- MXRA6
Previous GeneCards Identifiers for TNS1 Gene
- GC02M218492
- GC02M218375
- GC02M218664
- GC02M210519
Summaries for TNS1 Gene
-
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
GeneCards Summary for TNS1 Gene
TNS1 (Tensin 1) is a Protein Coding gene. Diseases associated with TNS1 include Multiple Mucosal Neuroma and Supraglottis Neoplasm. Among its related pathways are Integrin Pathway and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is TNS3.
UniProtKB/Swiss-Prot Summary for TNS1 Gene
-
Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.
Additional gene information for TNS1 Gene
- Monarch Initiative
- Search for TNS1 at DataMed
- Search for TNS1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNS1 Gene
Genomics for TNS1 Gene
GeneHancer (GH) Regulatory Elements for TNS1 Gene
Promoters and enhancers for TNS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TNS1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TNS1 gene promoter:
-
- AP-1
- ATF-2
- c-Fos
- c-Jun
- Hlf
- LUN-1
Genomic Locations for TNS1 Gene
Genomic Locations for TNS1 Gene
- chr2:217,799,588-218,033,982
- (GRCh38/hg38)
- Size:
- 234,395 bases
- Orientation:
- Minus strand
- chr2:218,664,512-218,867,718
- (GRCh37/hg19)
- Size:
- 203,207 bases
- Orientation:
- Minus strand
Genomic View for TNS1 Gene
Genes around TNS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q35 by HGNC
- 2q35 by Entrez Gene
- 2q35 by Ensembl
TNS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNS1 Gene
Proteins for TNS1 Gene
-
Protein details for TNS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HBL0-TENS1_HUMAN
- Recommended name:
- Tensin-1
- Protein Accession:
- Q9HBL0
- Q4ZG71
- Q6IPI5
Protein attributes for TNS1 Gene
- Size:
- 1735 amino acids
- Molecular mass:
- 185701 Da
- Quaternary structure:
-
- Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8.
Protein Expression for TNS1 Gene
Post-translational modifications for TNS1 Gene
- Rapidly cleaved by calpain II.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TNS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001294952.1
- XP_024308844.1
- XP_016860303.1
- XP_016860300.1
- XP_024308843.1
- XP_016860305.1
- XP_024308842.1
- XP_024308852.1
- XP_016860302.1
- NP_072174.3
- XP_024308841.1
- XP_024308851.1
- XP_024308837.1
- XP_024308847.1
- XP_024308839.1
- XP_024308849.1
- NP_001294951.1
- XP_024308840.1
- XP_024308850.1
- XP_016860304.1
- XP_024308836.1
- XP_024308846.1
- XP_016860301.1
- XP_024308845.1
- XP_024308838.1
- XP_024308848.1
- XP_011510025.1
Antibody Products
- Atlas Antibodies Anti-TNS1 Antibody (HPA036089) and Anti-TNS1 Antibody (HPA036090)
- Creative Diagnostics Anti-TNS1 monoclonal antibody, Anti-TNS1 (full length) polyclonal antibody, and Rabbit Anti-Human TNS1 Polyclonal antibody
- Novus Biologicals Antibodies for TNS1
-
Abcam antibodies for TNS1
- Invitrogen Antibodies for TNS1 (AFLGC-TNS1)
-
Biorbyt antibodies for TNS1
Protein Products
- Atlas Antibodies PrEST Antigen TNS1 (APrEST79565) and PrEST Antigen TNS1 (APrEST79566)
- Creative Biomart Recombinant Human TNS1 cell lysate and Recombinant Human TNS1 protein, His & T7-tagged
-
OriGene Purified Proteins for TNS1
- Search Origene for MassSpec and Protein Over-expression Lysates for TNS1
- Origene Custom Protein Services for TNS1
- antibodies-online: Show 3 available Tensin 1 Proteins ranked by validation data
- Compare Top Tensin 1 Proteins
-
Quality Products:
-
Abcam proteins for TNS1
Assay Products
- antibodies-online: Show 2 available Tensin 1 Elisa Kits ranked by validation data
- Compare Top Tensin 1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TNS1 Gene
Domains & Families for TNS1 Gene
Gene Families for TNS1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TNS1 Gene
Suggested Antigen Peptide Sequences for TNS1 Gene
- GenScript: Design optimal peptide antigens:
-
- TNS1 protein (A1L0S7_HUMAN)
- Tensin 1, isoform CRA_b (B2RU35_HUMAN)
- MSTP091 (E2PSI9_HUMAN)
- TNS1 protein (Q0VG54_HUMAN)
- TNS1 protein (Q0VG55_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TNS1 Gene
Function for TNS1 Gene
Molecular function for TNS1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.
Phenotypes From GWAS Catalog for TNS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 17190795 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for TNS1 Gene
- MGI mutant phenotypes for TNS1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TNS1:
-
- Increased mitotic index
- Decreased HPV16-GFP infection
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Downregulation of Wnt pathway after Wnt3A stimulation
- Decreased cell migration
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased transferrin (TF) endocytosis
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for TNS1 Gene
- MGI Knock Outs for TNS1:
-
- Tns1 Tns1<tm1Efu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for TNS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNS1
- genomics-online: gRNA clones - Search for available Tensin 1 gRNA products
- Overview of 73 available Tensin 1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for TNS1 - Select products 50% OFF >
- * TNS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TNS1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNS1
miRNA for TNS1 Gene
- miRTarBase miRNAs that target TNS1
-
- hsa-mir-335-5p (MIRT019227)
- hsa-mir-98-5p (MIRT027785)
- hsa-mir-4446-5p (MIRT607351)
- hsa-mir-6809-3p (MIRT607352)
- hsa-mir-6833-3p (MIRT607353)
- hsa-mir-4768-5p (MIRT607354)
- hsa-mir-4753-3p (MIRT607355)
- hsa-mir-6873-3p (MIRT607356)
- hsa-mir-4279 (MIRT607357)
- hsa-mir-6792-3p (MIRT607358)
- hsa-mir-4691-5p (MIRT607359)
- hsa-mir-627-3p (MIRT607360)
- hsa-mir-130b-5p (MIRT607361)
- hsa-mir-6817-3p (MIRT607362)
- hsa-mir-7110-3p (MIRT607363)
- hsa-mir-3679-3p (MIRT612263)
- hsa-mir-4659b-3p (MIRT634189)
- hsa-mir-4659a-3p (MIRT634190)
- hsa-mir-22-5p (MIRT634191)
- hsa-mir-6887-3p (MIRT634192)
- hsa-mir-3691-3p (MIRT634193)
- hsa-mir-5584-3p (MIRT634194)
- hsa-mir-148a-5p (MIRT634195)
- hsa-mir-942-5p (MIRT650904)
- hsa-mir-6783-5p (MIRT650905)
- hsa-mir-8055 (MIRT724965)
- hsa-mir-6739-3p (MIRT724966)
- hsa-mir-375 (MIRT724967)
- hsa-mir-1304-5p (MIRT724968)
- hsa-mir-6858-5p (MIRT724969)
- hsa-mir-4689 (MIRT724970)
- hsa-mir-1224-5p (MIRT724971)
- hsa-mir-3915 (MIRT724972)
- hsa-mir-6868-3p (MIRT724973)
- hsa-mir-8068 (MIRT724974)
- hsa-mir-4326 (MIRT724975)
- hsa-mir-5087 (MIRT724976)
- hsa-mir-4751 (MIRT724977)
- hsa-mir-5004-5p (MIRT724978)
- hsa-mir-1248 (MIRT724979)
- hsa-mir-1237-3p (MIRT724980)
- hsa-mir-4748 (MIRT724981)
- hsa-mir-4464 (MIRT724982)
- hsa-mir-548j-5p (MIRT732174)
- hsa-mir-142-5p (MIRT762652)
- hsa-mir-33a-5p (MIRT765696)
- hsa-mir-33b-5p (MIRT765705)
- hsa-mir-340-5p (MIRT765747)
- hsa-mir-4666a-3p (MIRT770828)
- hsa-mir-4729 (MIRT771772)
- hsa-mir-5590-3p (MIRT774869)
- hsa-mir-5700 (MIRT775203)
- hsa-mir-586 (MIRT775342)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TNS1
- Browse OriGene Inhibitory RNA Products For TNS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNS1
- genomics-online: shRNA clones - Search for available Tensin 1 shRNA products
- Overview of 73 available Tensin 1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TNS1
- Addgene plasmids for TNS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNS1
- Applied Biological Materials (abm): Clones for TNS1 - Select products 50% OFF >
- * TNS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TNS1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for TNS1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNS1 Gene
Localization for TNS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNS1 Gene
- Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 4 |
| nucleus | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Focal adhesion sites (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005925 | focal adhesion | IDA | 11023826 |
| GO:0009986 | cell surface | IEA | -- |
| GO:0030054 | cell junction | IEA | -- |
Pathways & Interactions for TNS1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Integrin Pathway |
FAK1 Signaling
.67
|
|
| 2 | Focal Adhesion | ||
Pathways by source for TNS1 Gene
1 BioSystems pathway for TNS1 Gene
1 Qiagen pathway for TNS1 Gene
- FAK1 Signaling
Interacting Proteins for TNS1 Gene
Selected Interacting proteins:
Q9HBL0-TENS1_HUMAN
ENSP00000171887
for TNS1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TNS1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007044 | cell-substrate junction assembly | IEA | -- |
| GO:0010761 | fibroblast migration | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
No data available for SIGNOR curated interactions for TNS1 Gene
Drugs & Compounds for TNS1 Gene
No Compound Related Data Available
Drug Products
- Atlas Antibodies PrEST Antigen TNS1 (APrEST79565) and PrEST Antigen TNS1 (APrEST79566)
- Creative Biomart Recombinant Human TNS1 cell lysate and Recombinant Human TNS1 protein, His & T7-tagged
Transcripts for TNS1 Gene
mRNA/cDNA for TNS1 Gene
- (3) REFSEQ mRNAs :
- (24) Additional mRNA sequences :
- (115) Selected AceView cDNA sequences:
- (24) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000171887 10331 bps (ENST00000171887.8)
- ENST00000310858 1792 bps (ENST00000310858.10)
- ENST00000413280 667 bps (ENST00000413280.5)
- ENST00000413554 1478 bps (ENST00000413554.5)
- ENST00000419504 5921 bps (ENST00000419504.5)
CRISPR Products
-
OriGene CRISPR knockouts for TNS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNS1
- genomics-online: gRNA clones - Search for available Tensin 1 gRNA products
- Overview of 73 available Tensin 1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for TNS1 - Select products 50% OFF >
- * TNS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TNS1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNS1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TNS1
- Browse OriGene Inhibitory RNA Products For TNS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNS1
- genomics-online: shRNA clones - Search for available Tensin 1 shRNA products
- Overview of 73 available Tensin 1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TNS1
- Addgene plasmids for TNS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNS1
- Applied Biological Materials (abm): Clones for TNS1 - Select products 50% OFF >
- * TNS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TNS1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||
| SP13: |
Expression for TNS1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Basal Cells Trachea
- Duct Cells Pancreatic Ducts
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Outflow Tract
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Kidney (Urinary System)
- Juxtaglomerular Cells Afferent Arteriole
-
Smooth Muscle (Muscoskeletal System)
- Juxtaglomerular Cells Afferent Arteriole
-
Blood (Hematopoietic System)
- Erythroblasts Hematopoietic Bone Marrow
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
- Dermis (Integumentary System)
- Fibroblasts
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for TNS1 Gene
This gene is overexpressed in Artery - Tibial (x5.8) and Artery - Aorta (x4.5).
This gene is overexpressed in Urinary Bladder (12.2), Prostate (8.2), and Gallbladder (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNS1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TNS1 Gene:
TNS1SOURCE GeneReport for Unigene cluster for TNS1 Gene:
Hs.471381mRNA Expression by UniProt/SwissProt for TNS1 Gene:
Q9HBL0-TENS1_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for TNS1 Gene
- Heart(4.7)
- Blood(4.5)
- Liver(4.5)
- Skin(4.4)
- Nervous system(3.5)
- Lung(3.4)
- Muscle(3.3)
- Kidney(3.1)
- Intestine(3)
- Thyroid gland(2.6)
- Pancreas(2.5)
- Stomach(2.5)
- Eye(2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for TNS1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNS1 Gene
Orthologs for TNS1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TNS1 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TNS1 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TNS1 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tns1 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tns1 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TNS1 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TNS1 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TNS1 32 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TNS1 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tns1 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tns1 33 32 |
|
OneToMany | |
| TNS1 (2 of 2) 33 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | by 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | tag-163 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany | |
| Cin.2758 32 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2758 32 |
|
- Species where no ortholog for TNS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for TNS1 Gene
- ENSEMBL:
- Gene Tree for TNS1 (if available)
- TreeFam:
- Gene Tree for TNS1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TNS1: view image
Paralogs for TNS1 Gene
(7) SIMAP similar genes for TNS1 Gene using alignment to 18 proteins:
- TENS1_HUMAN
- A1L0S7_HUMAN
- B2RU35_HUMAN
- C9J8K5_HUMAN
- C9JFT7_HUMAN
- C9JI43_HUMAN
- C9JZT0_HUMAN
- E7EMG1_HUMAN
- E7ERH1_HUMAN
- E9PF55_HUMAN
- E9PGF5_HUMAN
- H7C3Z4_HUMAN
- Q0VG54_HUMAN
- Q0VG55_HUMAN
- Q59G71_HUMAN
- Q6IPI5_HUMAN
- Q6PJM3_HUMAN
- Q86VB0_HUMAN
Variants for TNS1 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_048004 | A breast cancer sample | p.Phe1093Leu | |||
| rs1000012011 | -- | 217,951,666(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000020562 | -- | 217,993,768(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000048965 | -- | 217,967,575(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000061527 | -- | 217,950,764(-) | T/G | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4174n100 | CNV | gain | 25217958 |
| dgv4175n100 | CNV | gain | 25217958 |
| esv1006594 | CNV | deletion | 20482838 |
| esv2229410 | CNV | deletion | 18987734 |
| esv2495817 | CNV | insertion | 19546169 |
| esv2664314 | CNV | deletion | 23128226 |
| esv2670055 | CNV | deletion | 23128226 |
| esv2721471 | CNV | deletion | 23290073 |
| esv2760585 | CNV | gain | 21179565 |
| esv3594325 | CNV | gain | 21293372 |
| esv3594326 | CNV | loss | 21293372 |
| nsv460102 | CNV | loss | 19166990 |
| nsv460103 | CNV | loss | 19166990 |
| nsv470517 | CNV | loss | 18288195 |
| nsv475517 | CNV | novel sequence insertion | 20440878 |
| nsv527822 | CNV | loss | 19592680 |
| nsv528835 | CNV | loss | 19592680 |
| nsv584486 | CNV | loss | 21841781 |
| nsv584487 | CNV | loss | 21841781 |
| nsv834541 | CNV | loss | 17160897 |
| nsv954834 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
19.41;
98.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TNS1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNS1 Gene
Disorders for TNS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| multiple mucosal neuroma |
|
|
| supraglottis neoplasm |
|
|
| conjunctival nevus |
|
|
| mucocele of salivary gland |
|
|
| trigeminal nerve neoplasm |
|
|
Search TNS1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TNS1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TNS1 Gene
Publications for TNS1 Gene
- Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PMID: 16953426) Beaty TH … Scott AF (Human genetics 2006) 3 23 43 56
- Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A … Haiman CA (PLoS genetics 2011) 3 43 56
- Genome-wide association study identifies five loci associated with lung function. (PMID: 20010834) Repapi E … Tobin MD (Nature genetics 2010) 3 43 56
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 43 56
- Molecular characterization of human tensin. (PMID: 11023826) Chen H … Lo SH (The Biochemical journal 2000) 3 4 56
ExternalLinks
Products for TNS1 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TNS1
- Search Origene for MassSpec and Protein Over-expression Lysates for TNS1
- Origene Custom Protein Services for TNS1
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TNS1
- Browse OriGene Inhibitory RNA Products For TNS1
- OriGene qPCR primer pairs for TNS1
- OriGene CRISPR knockouts for TNS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TNS1
- Sino Biological Human cDNA Clone for TNS1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TNS1
- Novus Biologicals proteins and lysates for TNS1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TNS1
- Abcam proteins for TNS1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for TNS1 (AFLGC-TNS1)
- Addgene plasmids for TNS1
- antibodies-online: Show 12 available Tensin 1 Antibodies ranked by validation data
- Compare Top Tensin 1 Antibodies
- antibodies-online: Show 2 available Tensin 1 Elisa Kits ranked by validation data
- Compare Top Tensin 1 Elisa Kits
- Quality Products:
- antibodies-online: Show 3 available Tensin 1 Proteins ranked by validation data
- Compare Top Tensin 1 Proteins
- Quality Products:
- Horizon Cell Lines for TNS1
- genomics-online: cdna clones - Search for available Tensin 1 CDNA products
- Overview of 73 available Tensin 1 gene related products
- orf clones - Search for available Tensin 1 ORF products
- Overview of 73 available Tensin 1 gene related products
- genomics-online: gRNA clones - Search for available Tensin 1 gRNA products
- Overview of 73 available Tensin 1 gene related products
- genomics-online: primer clones - Search for available Tensin 1 Primer products
- Overview of 73 available Tensin 1 gene related products
- genomics-online: shRNA clones - Search for available Tensin 1 shRNA products
- Overview of 73 available Tensin 1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNS1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TNS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNS1
- Biorbyt antibodies for TNS1
Sources for TNS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource