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Aliases for TNRC6C Gene
Aliases for TNRC6C Gene
External Ids for TNRC6C Gene
- HGNC: 29318
- Entrez Gene: 57690
- Ensembl: ENSG00000078687
- OMIM: 610741
- UniProtKB: Q9HCJ0
Previous GeneCards Identifiers for TNRC6C Gene
- GC17P073557
- GC17P076002
- GC17P071424
- GC17P078004
Summaries for TNRC6C Gene
GeneCards Summary for TNRC6C Gene
TNRC6C (Trinucleotide Repeat Containing Adaptor 6C) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and PI3K/AKT activation. Gene Ontology (GO) annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is TNRC6A.
UniProtKB/Swiss-Prot Summary for TNRC6C Gene
-
Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Additional gene information for TNRC6C Gene
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNRC6C Gene
Genomics for TNRC6C Gene
GeneHancer (GH) Regulatory Elements for TNRC6C Gene
Promoters and enhancers for TNRC6C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TNRC6C on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TNRC6C gene promoter:
-
- AP-1
- c-Fos
- c-Jun
- Cart-1
- FosB
- Fra-1
- HNF-3beta
- JunB
- JunD
- STAT5A
Genomic Locations for TNRC6C Gene
Genomic Locations for TNRC6C Gene
- chr17:77,959,240-78,108,835
- (GRCh38/hg38)
- Size:
- 149,596 bases
- Orientation:
- Plus strand
- chr17:76,000,249-76,104,916
- (GRCh37/hg19)
- Size:
- 104,668 bases
- Orientation:
- Plus strand
Genomic View for TNRC6C Gene
Genes around TNRC6C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by HGNC
- 17q25.3 by Entrez Gene
- 17q25.3 by Ensembl
TNRC6C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNRC6C Gene
Proteins for TNRC6C Gene
-
Protein details for TNRC6C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HCJ0-TNR6C_HUMAN
- Recommended name:
- Trinucleotide repeat-containing gene 6C protein
- Protein Accession:
- Q9HCJ0
- G3XAB8
- Q86UE5
- Q8N3D8
- Q96MU9
Protein attributes for TNRC6C Gene
- Size:
- 1690 amino acids
- Molecular mass:
- 175964 Da
- Quaternary structure:
-
- Interacts with one or more of the argonaute family proteins AGO1, AGO2, AGO3 and AGO4. Interacts with PABPC1 and EIF4G1. Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex. Interacts with PAN3; the interaction mediates the association with the PAN complex.
- SequenceCaution:
-
- Sequence=BAB13408.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB71179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for TNRC6C Gene
Post-translational modifications for TNRC6C Gene
Other Protein References for TNRC6C Gene
Antibody Products
- Atlas Antibodies Anti-TNRC6C Antibody (HPA022007) and Anti-TNRC6C Antibody (HPA062051)
- Creative Diagnostics Anti-TNRC6C (aa 483-604) polyclonal antibody and Anti-TNRC6C (aa 550-600) polyclonal antibody
- Novus Biologicals Antibodies for TNRC6C
-
Abcam antibodies for TNRC6C
- Invitrogen Antibodies for TNRC6C (AFLGC-TNRC6C)
Protein Products
- Atlas Antibodies PrEST Antigen TNRC6C (APrEST75534) and PrEST Antigen TNRC6C (APrEST92217)
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TNRC6C
- Origene Custom Protein Services for TNRC6C
- Novus Biologicals proteins for TNRC6C
No data available for DME Specific Peptides for TNRC6C Gene
Domains & Families for TNRC6C Gene
Gene Families for TNRC6C Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TNRC6C Gene
Suggested Antigen Peptide Sequences for TNRC6C Gene
- GenScript: Design optimal peptide antigens:
-
- Trinucleotide repeat-containing gene 6C protein (TNR6C_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9HCJ0UniProtKB/Swiss-Prot:
TNR6C_HUMAN :- The silencing domain, also known as C-terminal effector domain (CED), can act in autonomous repression, including both translational inhibition and mRNA degradation.
- Belongs to the GW182 family.
- Domain:
-
- The silencing domain, also known as C-terminal effector domain (CED), can act in autonomous repression, including both translational inhibition and mRNA degradation.
- Family:
-
- Belongs to the GW182 family.
Function for TNRC6C Gene
Molecular function for TNRC6C Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Phenotypes From GWAS Catalog for TNRC6C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 19383768 |
Phenotypes for TNRC6C Gene
- MGI mutant phenotypes for TNRC6C:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TNRC6C:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for TNRC6C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNRC6C
- genomics-online: gRNA clones - Search for available TNRC6C gRNA products
- Overview of 55 available TNRC6C gene related products
- Applied Biological Materials (abm): CRISPR Clones for TNRC6C - Select products 50% OFF >
- * TNRC6C CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TNRC6C CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNRC6C
miRNA for TNRC6C Gene
- miRTarBase miRNAs that target TNRC6C
-
- hsa-mir-30b-5p (MIRT023444)
- hsa-mir-4509 (MIRT078989)
- hsa-mir-4643 (MIRT079004)
- hsa-mir-95-5p (MIRT079019)
- hsa-mir-320a (MIRT079021)
- hsa-mir-331-5p (MIRT079022)
- hsa-mir-320b (MIRT079023)
- hsa-mir-320c (MIRT079024)
- hsa-mir-548m (MIRT079028)
- hsa-mir-320d (MIRT079029)
- hsa-mir-4429 (MIRT079030)
- hsa-mir-4666a-5p (MIRT079031)
- hsa-mir-125b-2-3p (MIRT079046)
- hsa-mir-380-3p (MIRT079048)
- hsa-mir-378a-5p (MIRT251876)
- hsa-mir-1200 (MIRT251878)
- hsa-mir-4666b (MIRT289287)
- hsa-mir-212-3p (MIRT289306)
- hsa-mir-132-3p (MIRT289307)
- hsa-mir-4709-5p (MIRT289309)
- hsa-mir-7159-5p (MIRT289310)
- hsa-mir-1273e (MIRT448399)
- hsa-mir-580-3p (MIRT448400)
- hsa-mir-539-5p (MIRT448401)
- hsa-mir-4635 (MIRT448402)
- hsa-mir-1264 (MIRT448404)
- hsa-mir-7152-5p (MIRT546213)
- hsa-mir-3074-5p (MIRT546214)
- hsa-mir-5700 (MIRT546215)
- hsa-mir-6512-5p (MIRT553451)
- hsa-mir-548ay-3p (MIRT553452)
- hsa-mir-548at-3p (MIRT553453)
- hsa-mir-548as-3p (MIRT553454)
- hsa-mir-548t-3p (MIRT553455)
- hsa-mir-548ap-3p (MIRT553456)
- hsa-mir-548aa (MIRT553457)
- hsa-mir-629-3p (MIRT565266)
- hsa-mir-519e-5p (MIRT565267)
- hsa-mir-515-5p (MIRT565268)
- hsa-mir-3925-3p (MIRT565269)
- hsa-mir-766-3p (MIRT565270)
- hsa-mir-1305 (MIRT612348)
- hsa-mir-4652-3p (MIRT612349)
- hsa-mir-421 (MIRT612350)
- hsa-mir-505-3p (MIRT612351)
- hsa-mir-8064 (MIRT612352)
- hsa-mir-3182 (MIRT612353)
- hsa-mir-216b-3p (MIRT612354)
- hsa-mir-603 (MIRT612355)
- hsa-mir-8485 (MIRT612356)
- hsa-mir-5010-3p (MIRT652292)
- hsa-mir-1238-3p (MIRT652293)
- hsa-mir-670-3p (MIRT652294)
- hsa-mir-6844 (MIRT652295)
- hsa-mir-6881-3p (MIRT652296)
- hsa-mir-6780a-3p (MIRT652297)
- hsa-mir-7111-3p (MIRT652298)
- hsa-mir-877-3p (MIRT652299)
- hsa-mir-4677-5p (MIRT718209)
- hsa-mir-22-5p (MIRT718210)
- hsa-mir-2116-5p (MIRT718211)
- hsa-mir-676-5p (MIRT718212)
- hsa-mir-4659b-3p (MIRT723193)
- hsa-mir-4659a-3p (MIRT723194)
- hsa-mir-6875-3p (MIRT723195)
- hsa-mir-511-5p (MIRT723196)
- hsa-mir-502-5p (MIRT723197)
- hsa-mir-6830-3p (MIRT723198)
- hsa-mir-1915-5p (MIRT723199)
- hsa-mir-6841-3p (MIRT723200)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TNRC6C
- Browse OriGene Inhibitory RNA Products For TNRC6C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNRC6C
- genomics-online: shRNA clones - Search for available TNRC6C shRNA products
- Overview of 55 available TNRC6C gene related products
Clone Products
- Sino Biological Human cDNA Clone for TNRC6C
- Addgene plasmids for TNRC6C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNRC6C
- genomics-online: cdna clones - Search for available TNRC6C CDNA products
- Overview of 55 available TNRC6C gene related products
- orf clones - Search for available TNRC6C ORF products
- Overview of 55 available TNRC6C gene related products
- Applied Biological Materials (abm): Clones for TNRC6C - Select products 50% OFF >
- * TNRC6C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TNRC6C tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for TNRC6C
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNRC6C Gene
Localization for TNRC6C Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 4 |
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000932 | P-body | IBA | 21873635 |
| GO:0005654 | nucleoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016442 | RISC complex | IBA | 21873635 |
| GO:0035068 | micro-ribonucleoprotein complex | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for TNRC6C Gene
Pathways & Interactions for TNRC6C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | PI3K/AKT activation |
.89
|
|
| 3 | CDK-mediated phosphorylation and removal of Cdc6 |
.41
|
|
| 4 | Cellular Senescence (REACTOME) | ||
| 5 | Pre-NOTCH Expression and Processing | ||
Pathways by source for TNRC6C Gene
1 BioSystems pathway for TNRC6C Gene
37 Reactome pathways for TNRC6C Gene
Interacting Proteins for TNRC6C Gene
Selected Interacting proteins:
Q9HCJ0-TNR6C_HUMAN
ENSP00000336783
for TNRC6C Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TNRC6C
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0007223 | Wnt signaling pathway, calcium modulating pathway | TAS | -- |
| GO:0010628 | positive regulation of gene expression | TAS | -- |
| GO:0010629 | negative regulation of gene expression | TAS | -- |
| GO:0031047 | gene silencing by RNA | IEA | -- |
No data available for SIGNOR curated interactions for TNRC6C Gene
Drugs & Compounds for TNRC6C Gene
No Compound Related Data Available
Drug Products
- Atlas Antibodies PrEST Antigen TNRC6C (APrEST75534) and PrEST Antigen TNRC6C (APrEST92217)
Transcripts for TNRC6C Gene
mRNA/cDNA for TNRC6C Gene
- (2) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (143) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000301624 9632 bps (ENST00000301624.8)
- ENST00000335749 9740 bps (ENST00000335749.4)
- ENST00000585438 682 bps (ENST00000585438.1)
- ENST00000587990 600 bps (ENST00000587990.1)
- ENST00000588061 8419 bps (ENST00000588061.5)
CRISPR Products
-
OriGene CRISPR knockouts for TNRC6C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNRC6C
- genomics-online: gRNA clones - Search for available TNRC6C gRNA products
- Overview of 55 available TNRC6C gene related products
- Applied Biological Materials (abm): CRISPR Clones for TNRC6C - Select products 50% OFF >
- * TNRC6C CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TNRC6C CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNRC6C
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TNRC6C
- Browse OriGene Inhibitory RNA Products For TNRC6C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNRC6C
- genomics-online: shRNA clones - Search for available TNRC6C shRNA products
- Overview of 55 available TNRC6C gene related products
Clone Products
- Sino Biological Human cDNA Clone for TNRC6C
- Addgene plasmids for TNRC6C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNRC6C
- genomics-online: cdna clones - Search for available TNRC6C CDNA products
- Overview of 55 available TNRC6C gene related products
- orf clones - Search for available TNRC6C ORF products
- Overview of 55 available TNRC6C gene related products
- Applied Biological Materials (abm): Clones for TNRC6C - Select products 50% OFF >
- * TNRC6C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TNRC6C tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
Expression for TNRC6C Gene
This gene is overexpressed in Breast (51.7) and Heart (11.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNRC6C Gene
NURSA nuclear receptor signaling pathways regulating expression of TNRC6C Gene:
TNRC6CSOURCE GeneReport for Unigene cluster for TNRC6C Gene:
Hs.569831Evidence on tissue expression from TISSUES for TNRC6C Gene
- Nervous system(4.7)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for TNRC6C
- genomics-online: primer clones - Search for available TNRC6C Primer products
- Overview of 55 available TNRC6C gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNRC6C Gene
Orthologs for TNRC6C Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TNRC6C 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TNRC6C 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tnrc6c 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tnrc6c 32 |
|
||
| cow (Bos Taurus) |
Mammalia | TNRC6C 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TNRC6C 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TNRC6C 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TNRC6C 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TNRC6C 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tnrc6c 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tnrc6c 32 |
|
||
| TNRC6C (2 of 5) 33 |
|
OneToMany | |||
| TNRC6C (4 of 5) 33 |
|
OneToMany | |||
| TNRC6C (5 of 5) 33 |
|
OneToMany | |||
| TNRC6C (3 of 5) 33 |
|
OneToMany | |||
| tnrc6b 33 |
|
OneToMany | |||
| Dr.12790 32 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | gw 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for TNRC6C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for TNRC6C Gene
- ENSEMBL:
- Gene Tree for TNRC6C (if available)
- TreeFam:
- Gene Tree for TNRC6C (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TNRC6C: view image
Paralogs for TNRC6C Gene
Variants for TNRC6C Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000023578 | -- | 77,985,844(+) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000026329 | -- | 78,107,351(+) | A/C | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000049646 | -- | 78,033,869(+) | T/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000053833 | -- | 77,996,331(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000136001 | -- | 78,101,870(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv570e199 | CNV | deletion | 23128226 |
| esv3641322 | CNV | loss | 21293372 |
| esv3641323 | CNV | loss | 21293372 |
| nsv1064772 | CNV | gain | 25217958 |
| nsv2153 | CNV | deletion | 18451855 |
| nsv833554 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
3.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.89;
79.56% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TNRC6C Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNRC6C Gene
Disorders for TNRC6C Gene
Additional Disease Information for TNRC6C
No disorders were found for TNRC6C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNRC6C Gene
Publications for TNRC6C Gene
- Early origin and adaptive evolution of the GW182 protein family, the key component of RNA silencing in animals. (PMID: 26106978) Zielezinski A … Karlowski WM (RNA biology 2015) 2 3 56
- GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. (PMID: 21981923) Braun JE … Izaurralde E (Molecular cell 2011) 3 4 56
- miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs. (PMID: 21984184) Chekulaeva M … Filipowicz W (Nature structural & molecular biology 2011) 3 4 56
- miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. (PMID: 21984185) Fabian MR … Sonenberg N (Nature structural & molecular biology 2011) 3 4 56
- The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. (PMID: 19383768) Lazzaretti D … Izaurralde E (RNA (New York, N.Y.) 2009) 3 4 56
ExternalLinks
Products for TNRC6C Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TNRC6C
- Origene Custom Protein Services for TNRC6C
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TNRC6C
- Browse OriGene Inhibitory RNA Products For TNRC6C
- OriGene qPCR primer pairs for TNRC6C
- OriGene CRISPR knockouts for TNRC6C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TNRC6C
- Sino Biological Human cDNA Clone for TNRC6C
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TNRC6C
- Novus Biologicals proteins for TNRC6C
- Browse Antibodies
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- Browse Lysates
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- Abcam antibodies for TNRC6C
- Find your target
- Browse Primary Antibodies
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- Invitrogen Antibodies for TNRC6C (AFLGC-TNRC6C)
- Addgene plasmids for TNRC6C
- antibodies-online: Show 11 available TNRC6C Antibodies ranked by validation data
- Compare Top TNRC6C Antibodies
- antibodies-online: Search results for available TNRC6C related products ranked by validation data
- antibodies-online: Search results for available TNRC6C related products ranked by validation data
- Horizon Cell Lines for TNRC6C
- genomics-online: cdna clones - Search for available TNRC6C CDNA products
- Overview of 55 available TNRC6C gene related products
- orf clones - Search for available TNRC6C ORF products
- Overview of 55 available TNRC6C gene related products
- genomics-online: gRNA clones - Search for available TNRC6C gRNA products
- Overview of 55 available TNRC6C gene related products
- genomics-online: primer clones - Search for available TNRC6C Primer products
- Overview of 55 available TNRC6C gene related products
- genomics-online: shRNA clones - Search for available TNRC6C shRNA products
- Overview of 55 available TNRC6C gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNRC6C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNRC6C
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TNRC6C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNRC6C
Sources for TNRC6C Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource