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TNRC6C (Trinucleotide Repeat Containing Adaptor 6C) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and PI3K/AKT activation. Gene Ontology (GO) annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is TNRC6A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 19383768 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000932 | P-body | IBA | 21873635 |
GO:0005654 | nucleoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0016442 | RISC complex | IBA | 21873635 |
GO:0035068 | micro-ribonucleoprotein complex | IBA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | PI3K/AKT activation |
.89
|
|
3 | CDK-mediated phosphorylation and removal of Cdc6 |
.41
|
|
4 | Cellular Senescence (REACTOME) | ||
5 | Pre-NOTCH Expression and Processing |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006417 | regulation of translation | IEA | -- |
GO:0007223 | Wnt signaling pathway, calcium modulating pathway | TAS | -- |
GO:0010628 | positive regulation of gene expression | TAS | -- |
GO:0010629 | negative regulation of gene expression | TAS | -- |
GO:0031047 | gene silencing by RNA | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TNRC6C 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | TNRC6C 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Tnrc6c 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Tnrc6c 32 |
|
||
cow (Bos Taurus) |
Mammalia | TNRC6C 33 32 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | TNRC6C 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | TNRC6C 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | TNRC6C 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | TNRC6C 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | tnrc6c 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | tnrc6c 32 |
|
||
TNRC6C (2 of 5) 33 |
|
OneToMany | |||
TNRC6C (4 of 5) 33 |
|
OneToMany | |||
TNRC6C (5 of 5) 33 |
|
OneToMany | |||
TNRC6C (3 of 5) 33 |
|
OneToMany | |||
tnrc6b 33 |
|
OneToMany | |||
Dr.12790 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | gw 33 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000023578 | -- | 77,985,844(+) | G/C | genic_upstream_transcript_variant, intron_variant | |
rs1000026329 | -- | 78,107,351(+) | A/C | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
rs1000049646 | -- | 78,033,869(+) | T/A | genic_upstream_transcript_variant, intron_variant | |
rs1000053833 | -- | 77,996,331(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
rs1000136001 | -- | 78,101,870(+) | G/A | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv570e199 | CNV | deletion | 23128226 |
esv3641322 | CNV | loss | 21293372 |
esv3641323 | CNV | loss | 21293372 |
nsv1064772 | CNV | gain | 25217958 |
nsv2153 | CNV | deletion | 18451855 |
nsv833554 | CNV | gain+loss | 17160897 |
No disorders were found for TNRC6C Gene.