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TNRC6C (Trinucleotide Repeat Containing Adaptor 6C) is a Protein Coding gene. Diseases associated with TNRC6C include Epidermodysplasia Verruciformis 1. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is TNRC6A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 19383768 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000932 | P-body | IBA | 21873635 |
GO:0005654 | nucleoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | GAB1 signalosome |
.89
|
|
3 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.41
|
|
4 | Cellular Senescence (REACTOME) | ||
5 | Pre-NOTCH Expression and Processing |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006417 | regulation of translation | IEA | -- |
GO:0007223 | Wnt signaling pathway, calcium modulating pathway | TAS | -- |
GO:0010628 | positive regulation of gene expression | TAS | -- |
GO:0010629 | negative regulation of gene expression | TAS | -- |
GO:0031047 | gene silencing by RNA | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TNRC6C 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TNRC6C 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tnrc6c 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tnrc6c 30 |
|
||
Cow (Bos Taurus) |
Mammalia | TNRC6C 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TNRC6C 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TNRC6C 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TNRC6C 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TNRC6C 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tnrc6c 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tnrc6c 30 |
|
||
TNRC6C (2 of 5) 31 |
|
OneToMany | |||
TNRC6C (4 of 5) 31 |
|
OneToMany | |||
TNRC6C (5 of 5) 31 |
|
OneToMany | |||
TNRC6C (3 of 5) 31 |
|
OneToMany | |||
tnrc6b 31 |
|
OneToMany | |||
Dr.12790 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | gw 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
816806 | Uncertain Significance: Intellectual disability | 78,050,084(+) | G/A | MISSENSE_VARIANT | |
rs34293811 | - | p.Pro820Arg |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv570e199 | CNV | deletion | 23128226 |
esv3641322 | CNV | loss | 21293372 |
esv3641323 | CNV | loss | 21293372 |
nsv1064772 | CNV | gain | 25217958 |
nsv2153 | CNV | deletion | 18451855 |
nsv833554 | CNV | gain+loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
epidermodysplasia verruciformis 1 |
|
|