Aliases for TNRC6B Gene
External Ids for TNRC6B Gene
Previous GeneCards Identifiers for TNRC6B Gene
GeneCards Summary for TNRC6B Gene
TNRC6B (Trinucleotide Repeat Containing Adaptor 6B) is a Protein Coding gene. Diseases associated with TNRC6B include Global Developmental Delay With Speech And Behavioral Abnormalities and Epilepsy, Familial Temporal Lobe, 5. Among its related pathways are RET signaling and Pre-NOTCH Expression and Processing. Gene Ontology (GO) annotations related to this gene include nucleotide binding. An important paralog of this gene is TNRC6A.
UniProtKB/Swiss-Prot Summary for TNRC6B Gene
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923).